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Oral Oncology
Volume 36, Issue 1
, Pages 3-7
, January 2000
An overview of the cell cycle arrest protein, p21WAF1
References
- WAF-1, a potential mediator of p53 tumour suppression. Cell. 1993;75:817–825
- . The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin idependent kinases. Cell. 1993;75:805–816
- . p21 is a universal inhibitor of cyclin kinase. Nature. 1993;366:701–704
- . Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 1994;211:90–98
-
.
Use of a sensitive and efficient subtraction hybridisation protocol for the identification of genes differentially regulated during the induction of differentiated in human melanoma cells.
Molec. Cell Different. 1993;1:285–299
- . Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 1993;366:707–710
- . Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene. 1994;9:3407–3415
- . Regulation of p21WAF1/Cip1 expression by p53-independent pathways. Oncogene. 1996;12:1557–1564
-
p53-Dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
Genes and Development. 1995;9:935–944
- Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 1997;90:809–819
- Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nature Medicine. 1998;4:839–843
- . p53, guardian of Rb. Nature. 1994;372:21
- . Cell cycle expression and p53 regulation of cyclin-dependent kinase inhibitor p21. Oncogene. 1994;9:2261–2268
- . Induction of p21(WAF-1/CIP1) during differentiation. Oncogene. 1994;9:3389–3396
-
.
p53 and its implications in apoptosis.
Int. J. Oncol. 1995;6:1129–1135
- . Radio-induced modulation of transforming growth factor beta 1 sensitivity in a p53 wild-type human colorectal-cancer cell line. Int. J. Cancer. 1996;68:126–131
-
.
p53-dependent elevation of p21WAF1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system.
Molec. Cell Biol. 1998;18:1400–1407
- Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 1995;377:552–557
-
New functional activities for the p21 family of CDK inhibitors.
Genes and Development. 1997;27:847–862
- Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene. 1998;17:2827–2838
- . The p21 inhibitor of cyclin-dependent kinase controls DNA replication by interaction with PCNA. Nature. 1994;369:574–576
-
.
p21-containing cyclin kinases exist in both active and inactive states.
Genes and Development. 1994;8:1750–1758
-
.
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.
Molec. Biol. Cell. 1993;4:897–906
- . Induction of WAF1/Cip1 by a p53- independent pathway. Cancer Res. 1994;54:3391–3395
-
.
p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
Am. J. Pathol. 1995;47:884–886
-
Transforming growth-factor-beta-1 can induce Cip1/Waf 1 expression independent of the p53 pathway in ovarian-cancer cell.
Cell Growth and Differentiation. 1994;5:1307–1310
-
.
Transforming growth factor induces the cyclin-dependent kinase inhibitor p21 thought a p53-independent mechanism.
Proc. Natl. Acad. Sci. USA. 1995;92:5545–5549
-
.
p53-independent induction of p21 (WAF1/CIP1) during differentiation of HL-60 cells by tumor necrosis factor alpha.
Experimental Hematology. 1997;25:166
-
.
p53-independent induction of p21 (WAF1/CIP1) during differentiation of HL-60 cells by tumor necrosis factor alpha.
Int. J. Hematology. 1996;65:41–48
- . Differentiation and IFN gamma regulate WAF1/CIP1 transcription in p53-independent and p53-dependent pathways in epithelial cells. In Vivo. 1996;10:119–123
- p53-independent induction of WAF1/C1P1 in human leukemia-cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res. 1995;55:668–674
-
.
Effects of 1,25-dihydoxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells.
J. Steroid Biochem. Molec. Biol. 1996;58:395–401
- . Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-ras Ha, v-fos, or human transforming growth factor alpha. Cancer Res. 1996;56:4413–4423
- Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21WAF1/Cip1 by MyoD. Science. 1995;267:1018–1021
-
.
The CDK inhibitor p21WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells.
Oncogene. 1996;267:1018–1021
- . Association between the p21 codon 31 Al (Arg) allele and lung cancer. Hum. Hered. 1996;46:221–225
-
Kawasaki T, Tomita Y, Bilim V, Takeda M, Takahashi K, Kumanishi T. Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p21/WAF1/Cip1 and/or p53 gene alterations. Int J Cancer 1996;68:501–505.
- A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma. Cancer Res. 1995;55:1431–1435
- . Mice lacking p21Cip1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995;82:675–684
- . Repair defect in p21WAF1/Cip1 −/− human cancer cells. Cancer Res. 1996;56:2250–2255
- . Differentiational effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature. 1994;371:534–537
- . Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision repair. Curr. Biol. 1994;4:1062–1068
- . Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a possible mechanism for regulation of DNA replication. Oncogene. 1997;14:2313–2321
- Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry. 1995;34:8869–8875
-
.
p21(Cip1/Waf1) disrupts the recruitment of human Fenl by proliferating-cell nuclear antigen into the DNA replication complex.
Proc. Natl. Acad. Sci. USA. 1996;93:11597–11602
-
Savio M, Stivala LA, Scovassi AI et al. p21WAF1/Cip1 protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites. Oncogene 1996;13:1591–1598.
- . Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene. 1994;9:3397–3406
- . Expression of p21 (Waf1/Cip1) in head and neck cancer in relation to proliferation, differentiation, p53 status and cyclin D1 expression. J. Oral Pathol. Med. 1998;27:367–375
- . Relationship of p53 overexpression to other cell cycle regulatory proteins in oral squamous cell carcinoma. J. Oral Pathol. Med. 1998;27:376–381
- . Preneoplastic oral lesions: the clinical value of image cytometry DNA analysis, p53 and p21/WAF1 expression. Anticancer Res. 1998;18:3645–3650
- . Expression of p53 and p21(CIP1/WAF1) proteins in oral epithelial dysplasia and squamous cell carcinomas. Oncology Reports. 1999;6:539–545
- Cell cycle proteins and the development of oral squamous cell carcinoma. Oral Oncology. 1999;35:333–342
-
.
Expression of p53 and p21 proteins in oral squamous cell carcinoma: correlation with lymph node metastasis and response to chemoradiotherapy.
Pathology Res. Practice. 1998;194:821–830
- . Expression of cyclin dependent kinase inhibitor p21(waf1/cip1) in premalignant and malignant oral lesions: relationship with p53 status. Oral Oncol. 1998;34:353–360
- . p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncology. 1998;34:529–537
- . Expression of p21/waf1 in oral squamous cell carcinomas—correlation with p53 and mdm2 and cellular proliferation index. Oral Oncology. 1999;35:63–69
- WAF-1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994;54:1169–1174
- . p53-dependent apoptosis in the abscence of transcriptional activation of p53-target genes. Nature. 1994;370:220–223
- . Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking WAF1/Cip1. Nature. 1996;381:713–716
- . Loss of p21WAF1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res. 1997;54:4703–4706
- Overexpressed WAF-1/CIP1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin. Cancer Res. 1998;58:1538–1543
-
Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: role of a caspase cascade.
Mol. Cell. 1998;1:553–563
- . Caspase-mediated cleavage of p21WAF1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene. 1999;18:1131–1138
- . Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumour-suppressor genes. Oncogene. 1992;7:927–933
- . Frequent. p53 mutations in head and neck cancer. Cancer Res. 1992;52:5997–6000
- . p53 mutations in human cancers. Science. 1991;253:49–53
- . Tumor suppression by p21WAF1. Cancer Res. 1995;55:4536–4539
- . Relationships between g1 arrest and stability of the p53 and p21cip1/waf1 proteins following gamma-irradiation of human lymphoma cells. Cancer Res. 1995;55:2387–2393
- In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res. 1995;55:5151–5155
- . p21(WAF-1/CIP1) retards the growth of human squamous cell carcinoma in vivo. Oral Oncology. 1998;34:211–218
- . p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am. J. Pathol. 1995;147:884–888
- p21 RNA and protein expression in non-small cell lung carcinoma: evidence of p53-independent expression and association with tumoral differentiation. Oncogene. 1996;12:1319–1324
- Expression of p21WAF1/cip1 is heterogeneous and unrelated to proliferation index in human ovarian carcinoma. Int. J. Cancer. 1995;63:611–615
- Relationship between p21 expression and mutaion of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells. Clin. Cancer Res. 1996;2:1571–1575
- Expression of cyclin-dependent kinase inhibitor p21/WAF1/CIP1, in non-neoplastic mucosa and neoplasia of the stomach: relationship with p53 status and proliferative activity. J. Pathol. 1996;180:122–128
- p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx. J. Pathol. 1997;183:156–163
- . Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas. J. Pathol. 1997;181:140–145
- p21WAF1/Cip1 is associated with Cyclin D1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma. J. Pathol. 1998;184:265–271
- Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995;55:2910–2919
- . Expression of p21 WAF-1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas. Oral Oncology. 1998;34:198–203
- Correlations between p21 expression and clinicopathological findings p53 gene and protein alterations, and survival in patients with endometrial carcinoma. J. Pathol. 1997;183:318–324
- . p21, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. Int. J. Cancer. 1998;79:424–428
- Differentiation-associated overexpression of the cyclin-dependent kinase inhibitor p21waf-1 in human cutaneous squamous cell carcinoma. Am. J. Pathol. 1996;149:1139–1146
- Aberrant p21 (CIP1/WAF1) protein accumulation in head-and-neck cancer. Int. J. Cancer. 1997;74:383–389
- p21WAF1/Cip1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. J. Pathol. 1999;187:302–307
- WAF1/Cip 1 gene polymorphism and expression in carcinomas of the breast, ovary and endometrium. Am. J. Pathol. 1997;150:167–175
- Therapy for oral squamous cell carcinoma by tegafur and streptococcal agent OK-432 in combination with radiotherapy: association of the therapeutic effect with differentiation and apoptosis in the cancer cells. Apoptosis. 1997;2:227–238
PII: S1368-8375(99)00049-4
© 2000 Elsevier Science Ltd. All rights reserved.
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Oral Oncology
Volume 36, Issue 1
, Pages 3-7
, January 2000
