Oral Oncology
Volume 36, Issue 1 , Pages 3-7, January 2000

An overview of the cell cycle arrest protein, p21WAF1

Oral Diseases Group, Unit of Oral Surgery and Medicine, Dundee Dental Hospital and School, Park Place, Dundee DD1 4HN, UK

Received 16 June 1999; accepted 22 June 1999.

Abstract 

p21, also known as WAF1, Cip1, Sdi1, Mda 6 and Cap20 is a cell cycle protein that regulates and can arrest the cell cycle in G1 or S phase (either dependent or independent of p53). Its role may be pivotal in many cell processes including differentiation and apoptosis. This brief overview provides a summary of its presently known functions and indicates areas for further research, particularly in relation to oral malignant disease. Greater understanding of its role may lead to therapeutic advances in the management of malignant disease.

Keywords:  p21WAF1, Cell cycle, Arrest protein, Functions

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PII: S1368-8375(99)00049-4

Oral Oncology
Volume 36, Issue 1 , Pages 3-7, January 2000

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