Oral Oncology
Volume 48, Issue 2 , Pages 102-109 , February 2012

In vitro influence of the extracellular matrix in myoepithelial cells stimulated by malignant conditioned medium

  • Elizabeth F. Martinez

      Affiliations

    • Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil
    • Corresponding Author InformationCorresponding author. Address: Departamento de Patologia Oral, Instituto e Centro de Pesquisas São Leopoldo Mandic, Rua José Rocha Junqueira, 13, CEP 13045-610, Campinas, SP, Brazil. Tel./fax: +55 19 3211 3600.
    • ,
  • Ana Paula Dias Demasi

      Affiliations

    • Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil
    • ,
  • Marcelo Henrique Napimoga

      Affiliations

    • Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil
    • ,
  • Victor Elias Arana-Chavez

      Affiliations

    • Laboratory of Oral Biology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Albina Altemani

      Affiliations

    • Department of Pathology, State University of Campinas, Campinas, SP, Brazil
    • ,
  • Ney Soares de Araújo

      Affiliations

    • Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil
    • ,
  • Vera Cavalcanti de Araújo

      Affiliations

    • Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil

Received 2 August 2011 ,Revised 31 August 2011 ,Accepted 14 September 2011.

References 

  1. Sternlicht MD, Barsky SH. The myoepithelial defense: a host defense against cancer. Med Hypotheses. 1997;48:37–46
  2. Barsky SH, Karlin NJ. Mechanisms of disease: breast tumor pathogenesis and the role of the myoepithelial cell. Nat Clin Pract Oncol. 2006;3:138–151
  3. Shekhar MP, Pauley R, Heppner G. Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast. Breast Cancer Res. 2003;5:130–135
  4. Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML, et al. The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. Oncogene. 2000;19:3449–3459
  5. Araújo VC, Altemani A, Furuse C, Martins MT, de Araújo NS. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol. 2006;42:1011–1016
  6. Martinez EF, Demasi AP, Miguita L, Altemani A, Araújo NS, Araújo VC. FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. Oncol Rep. 2010;24:155–160
  7. Freedman VH, Shin SI. Cellular tumorigenicity in nude mice. Correlation with cell growth in semi-solid medium. Cell. 1974;3:355–359
  8. Miguita L, Martinez EF, de Araújo NS, de Araújo VC. FGF-2, TGFbeta-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. J Appl Oral Sci. 2010;18:83–91
  9. Sánchez A, Alvarez AM, Pagan R, Roncero C, Vilaró S, Benito M, et al. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. J Hepatol. 2000;32:242–250
  10. Safarians S, Sternlicht MD, Yamanishi DT, Love SM, Barsky SH. Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies. Cancer Res. 1996;56:3560–3569
  11. Sporn MB, Roberts AB. Autocrine, paracrine and endocrine mechanisms of growth control. Cancer Surv. 1985;4:627–632
  12. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569–571
  13. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008;8:604–617
  14. Miyamoto S, Katz BZ, Lafrenie RM, Yamada KM. Fibronectin and integrins in cell adhesion, signaling, and morphogenesis. Ann N Y Acad Sci. 1998;857:119–129
  15. Lafrenie RM, Yamada KM. Integrins and matrix molecules in salivary gland cell adhesion, signaling, and gene expression. Ann N Y Acad Sci. 1998;842:42–48
  16. Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW, Bissel MJ. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia. 2005;10:261–272
  17. Cutler LS. The role of extracellular matrix in the morphogenesis and differentiation of salivary glands. Adv Dent Res. 1990;4:27–33
  18. Miyamoto S, Teramoto H, Gutkind JS, Yamada KM. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol. 1996;135:1633–1642
  19. Araújo VC, Furuse C, Cury PR, Altemani A, Alvez VA, de Araújo NS. Tenascin and fibronectin expression in carcinoma ex-pleomorphic adenoma. Appl Immunohistochem Mol Morphol. 2008;16:48–53
  20. Araújo VC, Demasi AP, Furuse C, Altemani A, Alvez VA, Freitas LL, et al. Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma. Appl Immunohistochem Mol Morphol. 2009;17:312–318
  21. Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5:816–826
  22. Caicedo-Carvajal CE, Shinbrot T, Foty RA. Alpha5beta1 integrin–fibronectin interactions specify liquid to solid phase transition of 3D cellular aggregates. PLoS One 2010;5e11830.

PII: S1368-8375(11)00823-2

doi: 10.1016/j.oraloncology.2011.09.008

Oral Oncology
Volume 48, Issue 2 , Pages 102-109 , February 2012

Article Tools

* Image Usage & Resolution