Oral Oncology
Volume 48, Issue 2 , Pages 97-101 , February 2012

Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review

  • Giada A. Beltramini

      Affiliations

    • Department of Maxillofacial Surgery, IRCCS Istituto Ortopedico Galeazzi, Università degli Studi di Milano, Milano, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Maxillofacial Surgery, IRCCS Istituto Ortopedico Galeazzi, Università degli Studi di Milano, 35, via Francesco Sforza 20122, Milan, Italy. Tel.: +39 0255032532; fax: +39 0255032558.
    • ,
  • Olindo Massarelli

      Affiliations

    • Department of Maxillofacial Surgery, Azienda Ospedaliera-Universitaria di Sassari, Università di Sassari, Sassari, Italy
    • ,
  • Marco Demarchi

      Affiliations

    • Department of Maxillofacial Surgery, Fondazione IRCCS Ospedale Maggiore Policlinico, Università degli Studi di Milano, Mialno, Italy
    • ,
  • Chiara Copelli

      Affiliations

    • Department of Maxillofacial Surgery, Azienda Ospedaliera-Universitaria di Parma, Università di Parma, Parma, Italy
    • ,
  • Andrea Cassoni

      Affiliations

    • Department of Maxillofacial Surgery, Policlinico Umberto I, Università La Sapienza, Roma, Italy
    • ,
  • Valentino Valentini

      Affiliations

    • Department of Maxillofacial Surgery, Policlinico Umberto I, Università La Sapienza, Roma, Italy
    • ,
  • Antonio Tullio

      Affiliations

    • Department of Maxillofacial Surgery, Azienda Ospedaliera-Universitaria di Sassari, Università di Sassari, Sassari, Italy
    • ,
  • Aldo B Giannì

      Affiliations

    • Department of Maxillofacial Surgery, Fondazione IRCCS Ospedale Maggiore Policlinico, Università degli Studi di Milano, Mialno, Italy
    • ,
  • Enrico Sesenna

      Affiliations

    • Department of Maxillofacial Surgery, Azienda Ospedaliera-Universitaria di Parma, Università di Parma, Parma, Italy
    • ,
  • Alessandro Baj

      Affiliations

    • Department of Maxillofacial Surgery, Fondazione IRCCS Ospedale Maggiore Policlinico, Università degli Studi di Milano, Mialno, Italy

Received 10 May 2011 ,Revised 12 August 2011 ,Accepted 17 August 2011.

References 

  1. Woolgar JA, Scott J. Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue/floor of mouth. Head Neck. 1995;17:463–472
  2. Pitman KT. Rationale for elective neck dissection. Am J Otolaryngol. 2000;21:31–37
  3. Yao M, Epstein JB, Modi BJ, et al. Current surgical treatment of squamous cell carcinoma of the head and neck. Oral Oncol. 2007;43:213–223
  4. Shah JP, White EB. Head and Neck Surgery and Oncology. fourth ed.. Mosby: Edinburgh; 2003;
  5. Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, Mac Donald DG. Improved survival for patients with clinically T1/T2 N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck. 1999;21:517–525
  6. Kligerman J, Lima R, Soares J, et al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of the oral cavity. Am J Surg. 1994;168:391–394
  7. Yorozu A, Sykes AJ, Slevin NJ. Carcinoma of the hard palate treated with radiotherapy: a retrospective review of 31 cases. Oral Oncol. 2001;37:493–497
  8. Ogura I, Kurabayashi T, Sasaki T, Amagasa T, Okada N, Kaneda T. Maxillary bone invasion by gingival carcinoma as an indicator of cervical metastasis. Dentomaxillofac Radiol. 2003;32:291–294
  9. Simental AA, Johnson JT, Myers EN. Cervical metastasis from squamous cell carcinoma of the maxillary alveolus and hard palate. Laryngoscope. 2006;116:1682–1684
  10. Montes DM, Schmidt BL. Oral maxillary squamous cell carcinoma: management of the clinically negative neck. J Oral Maxillofac Surg. 2008;66:762–766
  11. Kruse ALD, Grätz KW. Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years. Head & Neck Oncology. 2009;1:28–32
  12. Lin HW, Bhattacharyya N. Survival impact of nodal disease in hard palate and maxillary alveolus cancer. Laryngoscope. 2009;119:312–315
  13. Mourouzis C, Pratt C, Brennan PA. Squamous cell carcinoma od the maxillary gingiva, alveolus, and hard palate: is there a need for elective neck dissection?. Br J Oral Maxillofac Surg. 2010;48:345–348
  14. Morris LGT, Patel SG, Shah JP, Ganly IG. High rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus. Head Neck. 2011;33:824–830
  15. Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T. Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck. 2002;24:731–736
  16. Sparano A, Weinstein G, Chalian A, Yodul M, Weber R. Multivariate predictors of occult neck metastasis in early oral tongue cancer. Otolaryngol Head Neck Surg. 2004;131:472–476
  17. Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G. Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997;80:351–356
  18. Capote A, Escorial V, Munoz-Guerra MF, Rodrıguez-Campo FJ, Gamallo C, Naval L. Elective neck dissection in early-stage oral squamous cell carcinoma – does it influence recurrence and survival?. Head Neck. 2007;29:3–11
  19. Genden EM, Ferlito A, Silver CE, Takes RP, Suarez C, Owen RP, et al. Contemporary management of cancer of the oral cavity. Eur Arch Otorhinolaryngol. 2010;267:1001–1017
  20. De Cicco C, Trifirò G, Calabrese L, Bruschini R, Ferrari ME, Travaini LL, et al. Lymphatic mapping to tailor selective lymphadenectomy in cN0 tongue carcinoma: beyond the sentinel node concept. Eur J Nucl Med Mol Imaging. 2006;33:900–905
  21. Alkureishi LW, Burak Z, Alvarez JA, Ballinger J, Bilde A, Britten AJ, et al European association of nuclear medicine oncology committee; European sentinel node biopsy trial committee. Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma. Ann Surg Oncol. 2009;16:3190–3210
  22. Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, et al. Sentinel node biopsy in head and neck squamous cell cancer: 5-years follow-up of a European multicenter trial. Ann Surg Oncol. 2010;17:2459–2464

PII: S1368-8375(11)00799-8

doi: 10.1016/j.oraloncology.2011.08.012

Oral Oncology
Volume 48, Issue 2 , Pages 97-101 , February 2012

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