Oral Oncology
Volume 46, Issue 9 , Pages 678-683 , September 2010

Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma

Received 9 April 2010 ,Revised 17 June 2010 ,Accepted 21 June 2010.

References 

  1. Kim MM, Califano JA. Molecular pathology of head-and-neck cancer. Int J Cancer. 2004;112(4):545–553
  2. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res. 1996;56:2488–2492
  3. Gollin SM. Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. Head Neck. 2001;23(3):238–253
  4. Brieger J, Jacob R, Riazimand HS, Essig E, Heinrich UR, Bittinger F, et al. chromosomal aberrations in premalignant and malignant squamous epithelium. Cancer Genet Cytogenet. 2003;144(2):148–155
  5. Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, et al. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res. 2004;64(17):5982–5987
  6. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res. 2001;61:3225–3229
  7. Bardwell VJ, Treisman R. The POZ domain: a conserved protein–protein interaction motif. Genes Dev. 1994;8:1664–1677
  8. Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee WK, et al. P53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat. Med. 1995;1(6):570–577
  9. Fujii H, Biel MA, Zhou W, Weitzman SA, Baylin SB, Gabrielson E. Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene. 1998;16:2159–2164
  10. Issa JP, Zehnbauer BA, Kaufmann SH, Biel MA, Baylin SB. HIC1 hypermethylation is a late event in hematopoietic neoplasms. Cancer Res. 1997;57:1678–1681
  11. Kanai Y, Hui AM, Sun L, Ushijima S, Sakamoto M, Tsuda H, et al. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology. 1999;29:703–709
  12. Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, et al. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat. Genet. 2003;33(2):197–202
  13. Zhang J, Martins CR, Fansler ZB, Roemer KL, Kincaid EA, Gustafson KS, et al. DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. Clin. Cancer Res. 2005;11(18):6544–6549
  14. Dong SM, Kim HS, Rha SH, Sidransky D. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res. 2001;7(7):1982–1986
  15. Eads CA, Lord RV, Wickramasinghe K, Long TL, Kurumboor SK, Bernstein L, et al. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res. 2001;61(8):3410–3418
  16. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 2001;10(7):687–692
  17. Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res. 2006;66(6):3338–3344
  18. Daskalakis M, Nguyen TT, Nguyen C, Guldberg P, Kohler G, Wijermans P, et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood. 2002;100(8):2957–2964
  19. Ruter B, Wijermans PW, Lubbert M. DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukaemia. Int. J. Hematol. 2004;80(2):128–135
  20. Welkoborsky HJ, Jacob R, Riazimand SH, Bernauer HS, Mann WJ. Molecular biologic characteristics of seven new cell lines of squamous cell carcinomas of the head and neck and comparison to fresh tumor tissue. Oncology. 2003;65:60–71
  21. Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, Koch WM, et al. Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck. 2007;29(2):163–188
  22. Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. U S A. 1996;93(18):9821–9826
  23. Rathi A, Virmani AK, Harada K, Timmons CF, Miyajima K, Hay RJ, et al. Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. Clin. Cancer Res. 2003;9(10):3674–3678
  24. Livak KJ, Schmittgen TG. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408
  25. Ahmed SA, Gogal RM, Walsh JE. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H] thymidine incorporation assay. J. Immunol. Methods. 1994;170:211–224
  26. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000;16:168–174
  27. Bender CM, Gonzalgo ML, Gonzales FA, Nguyen CT, Robertson KD, Jones PA. Roles of cell division and gene transcription in the methylation of CpG islands. Mol. Cell Biol. 1999;19:6690–6698

PII: S1368-8375(10)00212-5

doi: 10.1016/j.oraloncology.2010.06.016

Oral Oncology
Volume 46, Issue 9 , Pages 678-683 , September 2010

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