Oral Oncology
Volume 46, Issue 9 , Pages 636-643, September 2010

Prognostic evaluation of oral tongue cancer: Means, markers and perspectives (II)

  • Ibrahim O. Bello

      Affiliations

    • Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    • ,
  • Ylermi Soini

      Affiliations

    • Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
    • ,
  • Tuula Salo

      Affiliations

    • Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    • Corresponding Author InformationCorresponding author. Address: Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, FI-90014 Oulu, Finland. Tel.: +358 8 537 5592.

Received 10 May 2010; received in revised form 14 June 2010; accepted 16 June 2010. published online 16 July 2010.

Summary 

Squamous cell carcinoma of the oral (mobile) tongue (OTSCC) is increasingly regarded as a biologically different entity compared to cancer affecting other oral sites. It is more aggressive and generally associated with a higher rate of metastasis. This is the concluding part of our two-part article that examines the methods by which the behavior and prognosis of OTSCC has been studied, the prognostics markers, and the relevance and future direction of prognostic studies. In this part, we continue our discussion of the histopathologic and molecular prognostic factors, and serum and salivary biomarkers in of OTSCC, and emphasize the need to regard OTSCC as a high risk variant of oral cancer. We conclude with future direction of prognostic studies of OTSCC.

Keywords: Oral (mobile) tongue cancer, Squamous cell carcinoma, Survival, Prognosis, Prognostic factors, Review

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PII: S1368-8375(10)00191-0

doi:10.1016/j.oraloncology.2010.06.008

Oral Oncology
Volume 46, Issue 9 , Pages 636-643, September 2010

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