Oral Oncology
Volume 46, Issue 9 , Pages 630-635, September 2010

Prognostic evaluation of oral tongue cancer: Means, markers and perspectives (I)

  • Ibrahim O. Bello

      Affiliations

    • Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, FI-90014 Oulu, Finland
    • ,
  • Ylermi Soini

      Affiliations

    • Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
    • ,
  • Tuula Salo

      Affiliations

    • Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, FI-90014 Oulu, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358 8 537 5592.

Received 10 May 2010; received in revised form 14 June 2010; accepted 16 June 2010. published online 16 July 2010.

Summary 

Oral (mobile) tongue squamous cell carcinoma (OTSCC) is the most common cancer diagnosed within the oral cavity. Due to the inherent disadvantages of the mobile tongue OTSCC behaves aggressively and is generally associated with higher rates of occult metastasis and neck nodal metastasis than any other cancer of the oral cavity. The prognosis remains relatively poor and is still heavily reliant on TNM (tumor, node, metastasis) staging of the tumor despite a vast array of literature on possible prognostic indicators. This is a two-part article which examines the methods by which the behavior and prognosis of OTSCC has been studied, the prognostics markers, and the relevance and future direction of prognostic studies. In this first part, we discuss the relative merits of the methods used in prognostic studies and the clinicopathologic prognostic factors.

Keywords: Oral (mobile) tongue cancer, Squamous cell carcinoma, Survival, Prognosis, Prognostic factors, Review

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PII: S1368-8375(10)00189-2

doi:10.1016/j.oraloncology.2010.06.006

Oral Oncology
Volume 46, Issue 9 , Pages 630-635, September 2010

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