Oral Oncology
Volume 46, Issue 8 , Pages 622-626, August 2010

Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians

  • Manasi Mittal

      Affiliations

    • Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    • ,
  • Vaishali Kapoor

      Affiliations

    • Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    • ,
  • Bidhu Kalyan Mohanti

      Affiliations

    • Department of Radiation Oncology, BRA-IRCH, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    • ,
  • Satya Narayan Das

      Affiliations

    • Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 11 26593548; fax: +91 11 26589286.

Received 6 May 2010; received in revised form 3 June 2010; accepted 5 June 2010. published online 12 July 2010.

Summary 

We assessed the association of COX-2 polymorphisms at promoter sites −1195, −765 and at 3′UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR–RFLP. Although no significant difference was observed in the frequency of COX-2 −1195G>A, −765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 −1195G/A genotype showed higher while −765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with −1195G>A SNP (OR 3.07 at 95%CI) while −765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.

Keywords: Single nucleotide polymorphism, COX-2, Oral cancer, Asian Indians

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PII: S1368-8375(10)00185-5

doi:10.1016/j.oraloncology.2010.06.002

Oral Oncology
Volume 46, Issue 8 , Pages 622-626, August 2010

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