Head and neck cancer in a developing country: A population-based perspective across 8years

Attar, Esra; Dey, Subhojit; Hablas, Ahmad; Seifeldin, Ibrahim A.; Ramadan, Mohamed; Rozek, Laura S.; Soliman, Amr S.

doi:10.1016/j.oraloncology.2010.05.002

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Volume 46, Issue 8 , Pages 591-596, August 2010

Head and neck cancer in a developing country: A population-based perspective across 8years

Esra Attar
- Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI, USA
Subhojit Dey
- Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI, USA
Ahmad Hablas
- Gharbiah Cancer Registry, Tanta Cancer Center, Tanta, Gharbiah, Egypt
Ibrahim A. Seifeldin
- Gharbiah Cancer Registry, Tanta Cancer Center, Tanta, Gharbiah, Egypt
Mohamed Ramadan
- Gharbiah Cancer Registry, Tanta Cancer Center, Tanta, Gharbiah, Egypt
Laura S. Rozek
- Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
- Department of Otorhinolaryngology, School of Medicine, University of Michigan, Ann Arbor Michigan, USA
Amr S. Soliman
- Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI, USA
- Corresponding author. Address: Department of Epidemiology, University of Michigan, School of Public Health, 109 Observatory St., Ann Arbor, MI 48109, USA. Tel.: +1 (734) 764 5469; fax: +1 (734) 764 3192.

Received 24 March 2010; received in revised form 13 May 2010; accepted 14 May 2010. published online 09 July 2010.

Summary

Head and neck cancer (HNC) has been studied in different regions of the world but little is known about its incidence patterns in the Middle East and Egypt.

In this study from Egypt’s only population-based registry, we analyzed data from 1999 to 2006, to estimate incidence, incidence rate ratios (IRRs) and 95% confidence intervals (CIs) categorized by age, district and subsites.

Overall urban incidence of HNC was twice or more that of rural incidence for both males (IRR=2.59; 95% CI=2.26, 2.97) and females (IRR=2.00; 95% CI=1.64, 2.43). Highest urban–rural difference for males was seen in 40–49years (IRR=2.79; 95% CI=1.92, 4.05) and for females in 30–39years (IRR=2.94; 95% CI=1.60, 5.40). Among subsites, highest incidence among males was for larynx (1.53/10⁵) and among females for gum and mouth (0.48/10⁵). Maximum urban–rural difference in males was for paranasal sinus (IRR=4.66; 95% CI=1.88, 11.54) and in females for lip (IRR=8.91; 95% CI=1.89, 41.98).

The study underscores the patterns of HNC incidence in Egypt while indicating the need for future analytical studies investigating specific risk factors of HNC in this population.

Keywords: Head and neck cancer, Risk factors, Descriptive epidemiology, Urban–rural, Egypt, Africa, SEER