Oral Oncology
Volume 46, Issue 4 , Pages 311-316 , April 2010

Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma

  • Yaling Tang

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • ,
  • Xinhua Liang

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • Corresponding Author InformationCorresponding authors. Addressess: Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China. Tel.: +86 28 61153302; fax: +86 28 85503479 (X. Liang), Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China. Tel.: +86 28 61153399 (Y. Chen).
    • ,
  • Min Zheng

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • ,
  • Zhiyu Zhu

      Affiliations

    • Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • ,
  • Guiquan Zhu

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • ,
  • Jing Yang

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • ,
  • Yu Chen

      Affiliations

    • State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China
    • Corresponding Author InformationCorresponding authors. Addressess: Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China. Tel.: +86 28 61153302; fax: +86 28 85503479 (X. Liang), Department of Oral Pathology, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, People’s Republic of China. Tel.: +86 28 61153399 (Y. Chen).

Received 9 January 2010 ,Revised 2 February 2010 ,Accepted 2 February 2010.

References 

  1. van der Wal JE, Becking AG, Snow GB, van der Waal I. Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow-up. Head Neck. 2002;24(8):779–783
  2. Kokemueller H, Eckardt A, Brachvogel P, Hausamen JE. Adenoid cystic carcinoma of the head and neck – a 20 years experience. Int J Oral Maxillofac Surg. 2004;33(1):25–31
  3. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990;63(1):225–233
  4. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279(5350):577–580
  5. Naeem M, Dahiya M, Clark JI, Clark JI, Creech SD, Alkan S. Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis. Hum Pathol. 2002;33(12):1182–1187
  6. Bellone G, Silvestri S, Artusio E, Tibaudi D, Turletti A, Geuna M, et al. Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1. J Cell Physiol. 1997;172(1):1–11
  7. Gonzalez I, Andreu EJ, Panizo A, Inoges S, Fontalba A, Fernandez-Luna JL, et al. Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis. Clin Cancer Res. 2004;10(2):751–761
  8. Nakata Y, Kimura A, Katoh O, Kawaishi K, Hyodo H, Abe K, et al. C-kit point mutation of extracellular domain in patients with myeloproliferative disorders. Br J Haematol. 1995;91(3):661–663
  9. Gospodarowicz D. Growth factors and their action in vivo and in vitro. J Pathol. 1983;141(3):201–233
  10. Karin M. Signal transduction from cell surface to nucleus in development and disease. FASEB J. 1992;6(8):2581–25890
  11. Bellone G, Carbone A, Sibona N, Bosco O, Tibaudi D, Smirne C, et al. Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential. Cancer Res. 2001;61(5):2200–2206
  12. Yasuda A, Sawai H, Takahashi H, Ochi N, Matsuo Y, Funahashi H, et al. The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol Cancer. 2006;5:46
  13. Kim TW, Lee H, Kang YK, Choe MS, Ryu MH, Chang HM, et al. Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors. Clin Cancer Res. 2004;10(9):3076–3081
  14. Freier K, Flechtenmacher C, Walch A, Devens F, Mühling J, Lichter P, et al. Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland. Oral Oncol. 2005;41(9):934–939
  15. Sørensen KB, Godballe C, de Stricker K, Krogdahl A. Parotid carcinoma: expression of kit protein and epidermal growth factor receptor. J Oral Pathol Med. 2006;35(5):286–291
  16. Edwards PC, Bhuiya T, Kelsch RD. C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):586–593
  17. Locati LD, Perrone F, Losa M, Mela M, Casieri P, Orsenigo M, et al. Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol. 2009;45(11):986–990
  18. Ettl T, Schwarz S, Kleinsasser N, Hartmann A, Reichert TE, Driemel O. Overexpression of EGFR and absence of c-kit expression correlate with poor prognosis in salivary gland carcinomas. Histopathology. 2008;53(5):567–577
  19. Epivatianos A, Poulopoulos A, Dimitrakopoulos I, Andreadis D, Nomikos A, Vlahou S, et al. Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Oral Oncol. 2007;43(1):67–76
  20. Penner CR, Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol. 2002;15(7):687–691
  21. Chandan VS, Wilbur D, Faquin WC, Khurana KK. Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. Cancer. 2004;102(4):207–209
  22. Olmeda D, Montes A, Moreno-Bueno G, Flores JM, Portillo F, Cano A. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene. 2008;27(34):4690–4701
  23. Vitali R, Mancini C, Cesi V, Tanno B, Mancuso M, Bossi G, et al. Slug (SNAI2) down-regulation by RNA interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models. Clin Cancer Res. 2008;14(14):4622–4630
  24. DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial–mesenchymal transition in basal-like breast cancer. Cancer Res. 2009;69(13):5364–5373
  25. Pérez-Losada J, Sánchez-Martín M, Rodríguez-García A, Sánchez ML, Orfao A, Flores T, et al. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood. 2002;100(4):1274–1286
  26. Pérez-Losada J, Sánchez-Martín M, Pérez-Caro M, Pérez-Mancera PA, Sánchez-García I. The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene. 2003;22(27):4205–4211
  27. Seifert G, Sobin LH. The World Health Organization’s Histological Classification of Salivary Gland Tumors. A commentary on the second edition. Cancer. 1992;70(2):379–385
  28. da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, de Almeida OP, Kowalski LP. Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol. 2006;42(2):139–146
  29. Sung MW, Kim KH, Kim JW, Min YG, Seong WJ, Roh JL, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2003;129(11):1193–1197
  30. Shioiri M, Shida T, Koda K, Oda K, Seike K, Nishimura M, et al. Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. Br J Cancer. 2006;94(12):1816–1822
  31. Aslan DL, Oprea GM, Jagush SM, Gulbahce HE, Adams GL, Gaffney PM, et al. C-kit expression in adenoid cystic carcinoma does not have an impact on local or distant tumor recurrence. Head Neck. 2005;27(12):1028–1034
  32. Jeng YM, Lin CY, Hsu HC. Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma. Cancer Lett. 2000;154(1):107–111
  33. Holst VA, Marshall CE, Moskaluk CA, Frierson HF. Kit protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol. 1999;12(10):956–960
  34. Sequeiros-Santiago G, García-Carracedo D, Fresno MF, Suarez C, Rodrigo JP, Gonzalez MV. Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. Oncol Rep. 2009;21(5):1215–1222
  35. Yasuda A, Sawai H, Takahashi H, Ochi N, Matsuo Y, Funahashi H, et al. Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. Dig Dis Sci. 2007;52(9):2292–2300
  36. Sekido Y, Takahashi T, Ueda R, Takahashi M, Suzuki H, Nishida K, et al. Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene. Cancer Res. 1993;53(7):1709–1714
  37. Alves CC, Carneiro F, Hoefler H, Becker KF. Role of the epithelial–mesenchymal transition regulator Slug in primary human cancers. Front Biosci. 2009;14:3035–3050
  38. Maeda G, Chiba T, Okazaki M, Satoh T, Taya Y, Aoba T, et al. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int J Oncol. 2005;27(6):1535–1541
  39. Shih JY, Tsai MF, Chang TH, Chang YL, Yuan A, Yu CJ, et al. Transcription repressor Slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res. 2005;11(22):8070–8078
  40. Hotz B, Arndt M, Dullat S, Bhargava S, Buhr HJ, Hotz HG. Epithelial to mesenchymal transition: expression of the regulators snail, Slug, and twist in pancreatic cancer. Clin Cancer Res. 2007;13(16):4769–4776
  41. Côme C, Arnoux V, Bibeau F, Savagner P. Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression. J Mammary Gland Biol Neoplasia. 2004;9(2):183–193

PII: S1368-8375(10)00034-5

doi: 10.1016/j.oraloncology.2010.02.001

Oral Oncology
Volume 46, Issue 4 , Pages 311-316 , April 2010

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