Narrow band imaging and high definition television in evaluation of oral and oropharyngeal squamous cell cancer: A prospective study

Piazza, C.; Cocco, D.; Del Bon, F.; Mangili, S.; Nicolai, P.; Majorana, A.; Bolzoni Villaret, A.; Peretti, G.

doi:10.1016/j.oraloncology.2010.01.020

« Previous Next »Oral Oncology
Volume 46, Issue 4 , Pages 307-310, April 2010

Narrow band imaging and high definition television in evaluation of oral and oropharyngeal squamous cell cancer: A prospective study☆

C. Piazza
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
- Corresponding author. Tel.: +39 30 3995319; fax: +39 30 395212.
D. Cocco
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
F. Del Bon
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
S. Mangili
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
P. Nicolai
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
A. Majorana
- Department of Oral Medicine, Dental Clinic, University of Brescia, 25123 Brescia, Italy
A. Bolzoni Villaret
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
G. Peretti
- Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy

Received 15 January 2010; received in revised form 27 January 2010; accepted 27 January 2010. published online 02 March 2010.

Summary

Narrow band imaging (NBI) is an optical technique in which filtered light enhances superficial neoplasms based on their neoangiogenic pattern. The accuracy of NBI can be augmented by combining it with high definition television (HDTV). The aim of this study was to prospectively assess the diagnostic value of NBI in combination with HDTV in evaluation of oral (O) and oropharyngeal (OP) squamous cell carcinoma (SCC). Between April 2007 and December 2009, we analyzed 96 patients who were divided into 2 groups: Group A included 35 patients previously biopsied and diagnosed with OSCC or OPSCC and subjected to pre- and intraoperative HDTV white light (WL) and HDTV NBI endoscopy; Group B included 61 subjects already treated for OSCC or OPSCC and followed-up with HDTV WL and HDTV NBI. Fourteen of 35 (40%) patients in Group A showed adjunctive findings with NBI compared to standard WL. All of these findings were histologically confirmed. Twelve of 61 (20%) patients in Group B showed positive NBI findings, which were all confirmed by histology. The sensitivity, specificity, positive, negative predictive values, and accuracy for HDTV WL were 51%, 100%, 100%, 87%, and 68%, respectively, whilst for HDTV NBI were 96%, 100%, 100%, 93%, and 97%, respectively. Overall, 26 of 96 (27%) patients had a diagnostic advantage in applying NBI and HDTV: 6 patients received a diagnosis of recurrence and 1 of persistence after previous treatments; 5 showed a metachronous tumour; in 4 a synchronous tumour was diagnosed; 9 lesions were upstaged; in 1 patient previously diagnosed with an unknown primary by fine needle aspiration cytology on the neck, an anterior tonsillar pillar cancer was identified.

Keywords: Narrow band imaging, High definition television, Endoscopy, Squamous cell cancer, Oral cancer, Oropharyngeal cancer