Oral Oncology
Volume 46, Issue 4 , Pages 226-231 , April 2010

Potential biomarkers in saliva for oral squamous cell carcinoma

  • Jia-Yo Wu

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Chen Yi

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Ho-Ren Chung

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Duen-Jeng Wang

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Wen-Chien Chang

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Sheng-Yang Lee

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Che-Tung Lin

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Yueh-Chao Yang

      Affiliations

    • Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • Department of Dentistry, Cathay General Hospital, Taipei, Taiwan
    • ,
  • Wei-Chung Vivian Yang

      Affiliations

    • Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, No. 250 Wuxing Street, Taipei 110, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886 2 27361661x5208.

Received 22 October 2009 ,Revised 8 January 2010 ,Accepted 11 January 2010.

References 

  1. Liu SA, Tsai WC, Wong YK, Lin JC, Poon CK, Chao SY, et al. Nutritional factors and survival of patients with oral cancer. Head Neck. 2006;28(11):998–1007
  2. Su CC, Yang HF, Huang SJ, Lian Ie B. Distinctive features of oral cancer in Changhua county: high incidence, buccal mucosa preponderance, and a close relation to betel quid chewing habit. J Formos Med Assoc. 2007;106(3):225–233
  3. Chen CJ, You SL, Lin LH, Hsu WL, Yang YW. Cancer epidemiology and control in Taiwan: a brief review. Jpn J Clin Oncol. 2002;32(Suppl.):S66–S81
  4. Kantola S, Parikka M, Jokinen K, Hyrynkangs K, Soini Y, Alho OP, et al. Prognostic factors in tongue cancer – relative importance of demographic, clinical and histopathological factors. Br J Cancer. 2000;83(5):614–619
  5. Zimmermann BG, Wong DT. Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2008;44(5):425–429
  6. Carvalho AL, Jeronimo C, Kim MM, Henrique R, Zhang Z, Hoque MO, et al. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008;14(1):97–107
  7. Brinkman BM, Wong DT. Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol. 2006;18(3):228–233
  8. Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ, et al. Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. J Proteome Res. 2007;6(12):4549–4555
  9. Palmisano WA, Divine KK, Saccomanno G, Gilliland FD, Baylin SB, Herman JG, et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res. 2000;60(21):5954–5958
  10. Hoque MO, Begum S, Topaloglu O, Jeronimo C, Mambo E, Westra WH, et al. Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. Cancer Res. 2004;64(15):5511–5517
  11. Nunes DN, Kowalski LP, Simpson AJ. Detection of oral and oropharyngeal cancer by microsatellite analysis in mouth washes and lesion brushings. Oral Oncol. 2000;36(6):525–528
  12. Lee A, Kim Y, Han K, Kang CS, Jeon HM, Shim SI. Detection of tumor markers including carcinoembryonic antigen, APC, and cyclin D2 in fine-needle aspiration fluid of breast. Arch Pathol Lab Med. 2004;128(11):1251–1256
  13. Zimmermann BG, Park NJ, Wong DT. Genomic targets in saliva. Ann NY Acad Sci. 2007;1098:184–191
  14. Streckfus CF, Dubinsky WP. Proteomic analysis of saliva for cancer diagnosis. Expert Rev Proteomics. 2007;4(3):329–332
  15. Wong DT. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc. 2006;137(3):313–321
  16. Wong DT. Towards a simple, saliva-based test for the detection of oral cancer ‘oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance’. Expert Rev Mol Diagn. 2006;6(3):267–272
  17. Rhodus NL, Ho V, Miller CS, Myers S, Ondrey F. NF-kappaB dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma. Cancer Detect Prev. 2005;29(1):42–45
  18. Sawant SS, Zingde SM, Vaidya MM. Cytokeratin fragments in the serum: their utility for the management of oral cancer. Oral Oncol. 2008;44(8):722–732
  19. Yoshimura Y, Oka M, Harada T. Squamous cell carcinoma-antigen for detection of squamous cell and mucoepidermoid carcinoma after primary treatment: a preliminary report. J Oral Maxil Surg. 1990;48(12):1288–1292[discussion 1292–3]
  20. Silverman NA, Alexander JC, Chretien PB. CEA levels in head and neck cancer. Cancer. 1976;37(5):2204–2211
  21. Liao PH, Chang YC, Huang MF, Tai KW, Chou MY. Mutation of p53 gene codon 63 in saliva as a molecular marker for oral squamous cell carcinomas. Oral Oncol. 2000;36(3):272–276
  22. Viet CT, Schmidt BL. Methylation array analysis of preoperative and postoperative saliva DNA in oral cancer patients. Cancer Epidemiol Biomark Prev. 2008;17(12):3603–3611
  23. Franzmann EJ, Reategui EP, Pedroso F, Pernas FG, Karakullukcu BM, Carraway KL, et al. Soluble CD44 is a potential marker for the early detection of head and neck cancer. Cancer Epidemiol Biomark Prev. 2007;16(7):1348–1355
  24. Mager DL, Haffajee AD, Devlin PM, Norris CM, Posner MR, Goodson JM. The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects. J Trans Med. 2005;3:27
  25. Nakahara Y, Shintani S, Mihara M, Hino S, Hamakawa H. Detection of p16 promoter methylation in the serum of oral cancer patients. Int J Oral Maxil Surg. 2006;35(4):362–365
  26. Viet CT, Jordan RC, Schmidt BL. DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer. J Calif Dent Assoc. 2007;35(12):844–849
  27. Vairaktaris E, Serefoglou Z, Yapijakis C, Stathopoulos P, Vassiliou S, Derka S, et al. The interleukin-1 beta gene polymorphism +3953 C/T is not associated with risk for oral cancer. Anticancer Res. 2007;27(6B):3981–3986
  28. Vairaktaris E, Yiannopoulos A, Vylliotis A, Yapijakis C, Derka S, Vassiliou S, et al. Strong association of interleukin-6–174 G>C promoter polymorphism with increased risk of oral cancer. Int J Biol Markers. 2006;21(4):246–250
  29. Vairaktaris E, Yapijakis C, Serefoglou Z, Derka S, Vassiliou S, Nkenke E, et al. The interleukin-8 (−251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol. 2007;33(4):504–507
  30. Vairaktaris E, Vylliotis A, Spyridonodou S, Derka S, Vassiliou S, Nkenke E, et al. A DNA polymorphism of stromal-derived factor-1 is associated with advanced stages of oral cancer. Anticancer Res. 2008;28(1A):271–275
  31. Yapijakis C, Vairaktaris E, Vassiliou S, Vylliotis A, Nkenke E, Nixon AM, et al. The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer. J Cancer Res Clin Oncol. 2007;133(10):787–791
  32. Chang KC, Su IJ, Tsai ST, Shieh DB, Jin YT. Pathological features of betel quid-related oral epithelial lesions in Taiwan with special emphasis on the tumor progression and human papillomavirus association. Oncology. 2002;63(4):362–369
  33. Wong YK, Liu TY, Chang KW, Lin SC, Chao TW, Li PL, et al. p53 alterations in betel quid- and tobacco-associated oral squamous cell carcinomas from Taiwan. J Oral Pathol Med. 1998;27(6):243–248
  34. Wong YK, Liu CJ, Kwan PC, Chao SY. Microvascular density and vascular endothelial growth factor immunoreactivity as predictors of regional lymph node metastasis from betel-associated oral squamous cell carcinoma. J Oral Maxil Surg. 2003;61(11):1257–1262
  35. Su TR, Chang KL, Lee CH, Chen CH, Yang YH, Shieh TY. Expression of tumor necrosis factor-alpha and its soluble receptors in betel-quid-chewing patients at different stages of treatment for oral squamous cell carcinoma. Oral Oncol. 2004;40(8):804–810
  36. Akrish S, Buchner A, Dayan D. Oral cancer: diagnostic options as an aid to histology in order to predict patients at high risk for malignant transformation. Refuat Hapeh Vehashinayim. 2004;21(4):6–15, 93
  37. Conley BA, Taube SE. Prognostic and predictive markers in cancer. Dis Markers. 2004;20(2):35–43
  38. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res. 1987;95(3):229–249
  39. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166(4):375–381
  40. Bryne M, Koppang HS, Lilleng R, Stene T, Bang G, Dabelsteen E. New malignancy grading is a better prognostic indicator than Broders’ grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989;18(8):432–437
  41. Abbas NF, Labib El-Sharkawy S, Abbas EA, Abdel Monem El-Shaer M. Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(3):385–390
  42. Bacchiocchi R, Rubini C, Pierpaoli E, Borghetti G, Procacci P, Nocini PF, et al. Prognostic value analysis of urokinase-type plasminogen activator receptor in oral squamous cell carcinoma: an immunohistochemical study. BMC Cancer. 2008;8:220
  43. Nozaki S, Endo Y, Nakahara H, Yoshizawa K, Hashiba Y, Kawashiri S, et al. Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor. Oral Oncol. 2005;41(10):971–977
  44. Boonkitticharoen V, Kulapaditharom B, Leopairut J, Kraiphibul P, Larbcharoensub N, Cheewaruangroj W, et al. Vascular endothelial growth factor a and proliferation marker in prediction of lymph node metastasis in oral and pharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2008;134(12):1305–1311
  45. Chuang HC, Su CY, Huang HY, Huang CC, Chien CY, Du YY, et al. Active matrix metalloproteinase-7 is associated with invasion in buccal squamous cell carcinoma. Mod Pathol. 2008;21(12):1444–1450
  46. de Vicente JC, Fresno MF, Villalain L, Vega JA, Lopez Arranz JS. Immunoexpression and prognostic significance of TIMP-1 and -2 in oral squamous cell carcinoma. Oral Oncol. 2005;41(6):568–579
  47. Fong D, Spizzo G, Gostner JM, Gastl G, Moser P, Krammel C, et al. TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol. 2008;21(2):186–191
  48. Kleer CG, Teknos TN, Islam M, Marcus B, Lee JS, Pan Q, et al. RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res. 2006;12(15):4485–4490
  49. Matthias C, Mack B, Berghaus A, Gires O. Keratin 8 expression in head and neck epithelia. BMC Cancer. 2008;8:267
  50. Ota K, Fujimori H, Ueda M, Shiniriki S, Kudo M, Jono H, et al. Midkine as a prognostic biomarker in oral squamous cell carcinoma. Br J Cancer. 2008;99(4):655–662
  51. Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, et al. Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep. 2006;16(5):1071–1075
  52. Soland TM, Brusevold IJ, Koppang HS, Schenck K, Bryne M. Nerve growth factor receptor (p75 NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma. Histopathology. 2008;53(1):62–72
  53. Yamano Y, Uzawa K, Shinozuka K, Fushimi K, Ishigami T, Nomura H, et al. Hyaluronan-mediated motility: a target in oral squamous cell carcinoma. Int J Oncol. 2008;32(5):1001–1009
  54. Chiang WF, Liu SY, Fang LY, Lin CN, Wu MH, Chen YC, et al. Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. Oral Oncol. 2008;44(4):325–334
  55. Harada H, Omura K, Nakajima Y, Hasegawa S, Mogi S. Cyclin B1 is useful to predict occult cervical lymph node metastases in tongue carcinoma. J Exp Clin Cancer Res. 2006;25(3):351–356
  56. Ishikawa T, Nakashiro K, Hara S, Klosek SK, Li C, Shintani S, et al. CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. Int J Oncol. 2006;28(1):61–66
  57. Lo Muzio L, Santarelli A, Caltabiano R, Rubini C, Pieramici T, Trevisiol L, et al. P63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma. Hum Pathol. 2005;36(2):187–194
  58. Nemes JA, Nemes Z, Marton IJ. P21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. J Oral Pathol Med. 2005;34(5):274–279
  59. Lim J, Kim JH, Paeng JY, Kim MJ, Hong SD, Lee JI, et al. Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol. 2005;58(11):1199–1205
  60. Takes RP, Baatenburg De Jong RJ, Alles MJ, Meeuwis CA, Marres HA, Knegt PP, et al. Markers for nodal metastasis in head and neck squamous cell cancer. Arch Otolaryngol Head Neck Surg. 2002;128(5):512–518
  61. Diniz-Freitas M, Garcia-Caballero T, Antunez-Lopez J, Gandara-Rey JM, Garcia-Garcia A. Reduced E-cadherin expression is an indicator of unfavourable prognosis in oral squamous cell carcinoma. Oral Oncol. 2006;42(2):190–200
  62. Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J, et al. Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours. J Laryngol Otol. 2006;120(4):298–304
  63. Chen HH, Yu CH, Wang JT, Liu BY, Wang YP, Sun A, et al. Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. Oral Oncol. 2007;43(2):122–129
  64. Duffy SA, Taylor JM, Terrell JE, Islam M, Li Y, Fowler KE, et al. Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer. 2008;113(4):750–757
  65. Lo Muzio L, Farina A, Rubini C, Coccia E, Capogreco M, Colella G, et al. Effect of c-Met expression on survival in head and neck squamous cell carcinoma. Tumour Biol. 2006;27(3):115–121
  66. Mathe M, Suba Z, Nemeth Z, Tatrai P, Fule T, Borgulya G, et al. Stromal syndecan-1 expression is an adverse prognostic factor in oral carcinomas. Oral Oncol. 2006;42(5):493–500
  67. Hagiwara S, Murakumo Y, Sato T, Shigetomi T, Mitsudo K, Tohnai I, et al. Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity. Cancer Sci. 2008;99(10):1916–1923
  68. Schlieman MG, Fahy BN, Ramsamooj R, Beckett L, Bold RJ. Incidence, mechanism and prognostic value of activated Akt in pancreas cancer. Br J Cancer. 2003;89(11):2110–2115
  69. Pyo SW, Hashimoto M, Kim YS, Kim CH, Lee SH, Johnson KR, et al. Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma: correlation with the clinicopathologic features and patient outcome. J Cranio Maxil Surg. 2007;35(1):1–9
  70. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tanaka T, Takamori K, et al. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. J Oral Pathol Med. 2006;35(5):301–306
  71. Lo Muzio L, Campisi G, Farina A, Rubini C, Pastore L, Giannone N, et al. Effect of p63 expression on survival in oral squamous cell carcinoma. Cancer Invest. 2007;25(6):464–469
  72. Warnakulasuriya S, Soussi T, Maher R, Johnson N, Tavassoli M. Expression of p53 in oral squamous cell carcinoma is associated with the presence of IgG and IgA p53 autoantibodies in sera and saliva of the patients. J Pathol. 2000;192(1):52–57
  73. Yamazaki Y, Chiba I, Ishikawa M, Satoh C, Notani K, Ohiro Y, et al. Serum p53 antibodies as a prognostic indicator in oral squamous cell carcinoma. Odontology. 2008;96(1):32–37
  74. Chen CH, Lin YS, Lin CC, Yang YH, Ho YP, Tsai CC. Elevated serum levels of a c-erbB-2 oncogene product in oral squamous cell carcinoma patients. J Oral Pathol Med. 2004;33(10):589–594
  75. Nagler R, Bahar G, Shpitzer T, Feinmesser R. Concomitant analysis of salivary tumor markers – a new diagnostic tool for oral cancer. Clin Cancer Res. 2006;12(13):3979–3984
  76. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, et al. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008;14(19):6246–6252
  77. Dowling P, Wormald R, Meleady P, Henry M, Curran A, Clynes M. Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis. J Proteomics. 2008;71(2):168–175
  78. Pickering V, Jordan RC, Schmidt BL. Elevated salivary endothelin levels in oral cancer patients – a pilot study. Oral Oncol. 2007;43(1):37–41
  79. Almadori G, Bussu F, Galli J, Limongelli A, Persichilli S, Zappacosta B, et al. Salivary glutathione and uric acid levels in patients with head and neck squamous cell carcinoma. Head Neck. 2007;29(7):648–654
  80. Katakura A, Kamiyama I, Takano N, Shibahara T, Muramatsu T, Ishihara K, et al. Comparison of salivary cytokine levels in oral cancer patients and healthy subjects. Bull Tokyo Dent Coll. 2007;48(4):199–203
  81. SahebJamee M, Eslami M, AtarbashiMoghadam F, Sarafnejad A. Salivary concentration of TNF alpha, IL1 alpha, IL6, and IL8 in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2008;13(5):E292–E295
  82. Tan W, Sabet L, Li Y, Yu T, Klokkevold PR, Wong DT, et al. Optical protein sensor for detecting cancer markers in saliva. Biosens Bioelectron. 2008;24(2):266–271
  83. Zhong LP, Chen GF, Xu ZF, Zhang X, Ping FY, Zhao SF. Detection of telomerase activity in saliva from oral squamous cell carcinoma patients. Int J Oral Maxil Surg. 2005;34(5):566–570
  84. Ye DX, Xu Q, Chen WT, Zhu HG, Lin GC, Jiang CH, et al. Immunodetections and analysis of peripheral blood for patients with oral cancer undergoing operation. Shanghai Kou Qiang Yi Xue. 2004;13(2):83–86
  85. Zhong LP, Zhou XJ, Wei KJ, Yang X, Ma CY, Zhang CP, et al. Application of serum tumor markers and support vector machine in the diagnosis of oral squamous cell carcinoma. Shanghai Kou Qiang Yi Xue. 2008;17(5):457–460
  86. Chen YC, Li TY, Tsai MF. Analysis of the saliva from patients with oral cancer by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2002;16(5):364–369
  87. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, et al. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004;10(24):8442–8450
  88. Lin PY, Yu CH, Wang JT, Chen HH, Cheng SJ, Kuo MY, et al. Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med. 2008;37(1):18–25
  89. Guerin LA, Hoffman HT, Zimmerman MB, Robinson RA. Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma. Arch Pathol Lab Med. 2006;130(2):158–164
  90. Angiero F, Berenzi A, Benetti A, Rossi E, Del Sordo R, Sidoni A, et al. Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity. Anticancer Res. 2008;28(5A):2535–2539
  91. Mollaoglu N, Vairaktaris E, Nkenke E, Neukam FW, Ries J. Expression of MAGE-A12 in oral squamous cell carcinoma. Dis Markers. 2008;24(1):27–32
  92. Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, et al. Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas. Cancer Epidemiol Biomark Prev. 2005;14(1):108–119
  93. de Oliveira LR, Ribeiro-Silva A, Zucoloto S. Prognostic impact of p53 and p63 immunoexpression in oral squamous cell carcinoma. J Oral Pathol Med. 2007;36(4):191–197
  94. Foschini MP, Cocchi R, Morandi L, Marucci G, Pennesi MG, Righi A, et al. E-cadherin loss and delta Np73L expression in oral squamous cell carcinomas showing aggressive behavior. Head Neck. 2008;30(11):1475–1482
  95. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tanaka T, Tomoyose T, et al. The relationship of the histologic grade at the deep invasive front and the expression of Ki-67 antigen and p53 protein in oral squamous cell carcinoma. J Oral Pathol Med. 2005;34(10):602–607
  96. Qi G, Ogawa I, Kudo Y, Miyauchi M, Siriwardena BS, Shimamoto F, et al. Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch. 2007;450(3):297–302
  97. Ye H, Wang A, Lee BS, Yu T, Sheng S, Peng T, et al. Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma. Cancer Genomics Proteomics. 2008;5(2):85–94
  98. Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, Lee JJ, et al. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer. 2006;107(3):563–569
  99. Zhang WM, Lo Muzio L, Rubini C, Yan G. Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma. Oncol Rep. 2005;13(6):1095–1099

PII: S1368-8375(10)00011-4

doi: 10.1016/j.oraloncology.2010.01.007

Oral Oncology
Volume 46, Issue 4 , Pages 226-231 , April 2010

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