Potential biomarkers in saliva for oral squamous cell carcinoma

Wu, Jia-Yo; Yi, Chen; Chung, Ho-Ren; Wang, Duen-Jeng; Chang, Wen-Chien; Lee, Sheng-Yang; Lin, Che-Tung; Yang, Yueh-Chao; Yang, Wei-Chung Vivian

doi:10.1016/j.oraloncology.2010.01.007

« Previous Next »Oral Oncology
Volume 46, Issue 4 , Pages 226-231, April 2010

Potential biomarkers in saliva for oral squamous cell carcinoma

Jia-Yo Wu
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
- Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
Chen Yi
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Ho-Ren Chung
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Duen-Jeng Wang
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Wen-Chien Chang
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
- Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
Sheng-Yang Lee
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Che-Tung Lin
- School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
- Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
Yueh-Chao Yang
- Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
- Department of Dentistry, Cathay General Hospital, Taipei, Taiwan
Wei-Chung Vivian Yang
- Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, No. 250 Wuxing Street, Taipei 110, Taiwan
- Corresponding author. Tel.: +886 2 27361661x5208.

Received 22 October 2009; received in revised form 8 January 2010; accepted 11 January 2010. published online 08 February 2010.

Summary

Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.

Keywords: Body fluid, Biomarker, Diagnosis, Genomics, Oral squamous cell carcinoma, Prognosis, Proteomics, Saliva