Oral Oncology
Volume 46, Issue 3 , Pages 154-157 , March 2010

Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

  • Zuoqing Dong

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    • ,
  • Shaohua Liu

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    • ,
  • Chengjun Zhou

      Affiliations

    • Department of Pathology, The Second Hospital of Shandong University, Jinan 250033, PR China
    • ,
  • Tomoki sumida

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
    • ,
  • Hiroyuki Hamakawa

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
    • ,
  • Zhenggang Chen

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    • ,
  • Pei Liu

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    • ,
  • Fengcai Wei

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +86 13705311262; fax: +86 53186927544.

Received 1 October 2009 ,Revised 14 November 2009 ,Accepted 16 November 2009.

References 

  1. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 1990;61(1):49–59
  2. Kadesch T. Consequences of heteromeric interactions among helix-loop-helix proteins. Cell Growth Differ. 1993;4(1):49–55
  3. Norton JD, Deed RW, Craggs G, Sablitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol. 1998;8(2):58–65
  4. Benezra R, Rafii S, Lyden D. The Id proteins and angiogenesis. Oncogene. 2001;20(58):8334–8341
  5. Norton JD, Atherton GT. Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol. 1998;18(4):2371–2381
  6. Lasorella A, Uo T, Iavarone A. Id proteins at the cross-road of development and cancer. Oncogene. 2001;20(58):8326–8333
  7. Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O’Reilly R, et al. Id-1 and Id-3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 1999;401(6754):670–677
  8. Schoppmann SF, Schindl M, Bayer G, Aumayr K, Dienes J, Horvat R, et al. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int J Cancer. 2003;104(6):677–682
  9. Ouyang XS, Wang X, Lee DT, Tsao SW, Wong YC. Over expression of Id-1 in prostate cancer. J Urol. 2002;167(6):2598–2602
  10. Langlands K, Down GA, Kealey T. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res. 2000;60(21):5929–5933
  11. Nishimine M, Nakamura M, Mishima K, Kishi M, Kirita T, Sugimura M, et al. Id proteins are overexpressed in human oral squamous cell carcinomas. J Oral Pathol Med. 2003;32(6):350–357
  12. Ling MT, Lau TC, Zhou C, Chua CW, Kwok WK, Wang Q, et al. Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis. 2005;26(10):1668–1676
  13. Hansen S, Grabau DA, Rose C, Bak M, Sørensen FB. Angiogenesis in breast cancer: a comparative study of the observer variability of methods for determining microvessel density. Lab Invest. 1998;78(12):1563–1573
  14. Deed RW, Armitage S, Norton JD. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J Biol Chem. 1996;271(39):23603–23606
  15. Yuen HF, Chan YP, Chan KK, Chu YY, Wong ML, Law SY, et al. Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer. 2007;97(10):1409–1415
  16. Meteoglu I, Meydan N, Erkus M. Id-1: regulator of EGFR and VEGF and potential target for colorectal cancer therapy. J Exp Clin Cancer Res. 2008;27:69
  17. Schindl M, Schoppmann SF, Ströbel T, Heinzl H, Leisser C, Horvat R, et al. Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin Cancer Res. 2003;9(2):779–785

PII: S1368-8375(09)00974-9

doi: 10.1016/j.oraloncology.2009.11.005

Oral Oncology
Volume 46, Issue 3 , Pages 154-157 , March 2010

Article Tools

* Image Usage & Resolution