Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Dong, Zuoqing; Liu, Shaohua; Zhou, Chengjun; sumida, Tomoki; Hamakawa, Hiroyuki; Chen, Zhenggang; Liu, Pei; Wei, Fengcai

doi:10.1016/j.oraloncology.2009.11.005

« Previous Next »Oral Oncology
Volume 46, Issue 3 , Pages 154-157, March 2010

Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Zuoqing Dong
- Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
Shaohua Liu
- Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
Chengjun Zhou
- Department of Pathology, The Second Hospital of Shandong University, Jinan 250033, PR China
Tomoki sumida
- Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
Hiroyuki Hamakawa
- Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan
Zhenggang Chen
- Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
Pei Liu
- Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
Fengcai Wei
- Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China
- Corresponding author. Tel.: +86 13705311262; fax: +86 53186927544.

Received 1 October 2009; received in revised form 14 November 2009; accepted 16 November 2009. published online 07 January 2010.

Summary

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p=0.013), lymph node metastasis (p=0.001), tumor stage (p=0.031) and tumor recurrence (p=0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r=0.223, p=0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.