Oral Oncology
Volume 46, Issue 1 , Pages 49-55 , January 2010

Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins

  • Tsai-Ying Huang

      Affiliations

    • Department of Radiation Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Lee-Ping Hsu

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Yu-Hsuan Wen

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Tung-Tsun Huang

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Yu-Fu Chou

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Chia-Fong Lee

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • ,
  • Miao-Chun Yang

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Yi-Kuo Chang

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • ,
  • Peir-Rong Chen

      Affiliations

    • Department of Otolaryncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    • Department of Medicine, Tzu Chi University, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author. Address: Buddhist Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien, Taiwan. Tel.: +886 3 8561825; fax: +886 3 8560977.

Received 25 August 2009 ,Revised 26 October 2009 ,Accepted 28 October 2009.

References 

  1. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937–1944
  2. Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945–1952
  3. Fukano H, Matsuura H, Hasegawa Y, et al. Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma. Head Neck. 1997;19:205–210
  4. Anthony S, Gregory W, Ara C, et al. Multivariate predictors of occult neck metastasis in early oral tongue cancer. Otolaryngol Head Neck Surg. 2004;131:472–476
  5. O-charoenrat P, Pillai G, Patel S, et al. Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer. Oral Oncol. 2003;39:386–390
  6. Al Rajhi N, Khafaga Y, El Husseiny J, et al. Early stage carcinoma of oral tongue: prognostic factors for local control and survival. Oral Oncol. 2000;36:508–514
  7. Spiro RH, Huvos AG, Wong GY, Spiro JD, Gnecco CA, Strong EW. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg. 1986;152:345–350
  8. Nathanson A, Agren K, Biorklund A, et al. Evaluation of some prognostic factors in small squamous cell carcinoma of the mobile tongue: a multicenter study in Sweden. Head Neck. 1989;11:387–392
  9. Fakih AR, Rao RS, Borges AM, Patel AR. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg. 1989;158:309–313
  10. Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T. Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck. 2002;24:731–736
  11. Byers RM, El Naggar AK, Lee YY, et al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?. Head Neck. 1998;20:138–144
  12. Onercl M, Yilmaz T, Gedikoglu G. Tumor thickness as a predictor of cervical lymph node metastasis in squamous cell carcinoma of the lower lip. Otolaryngol Head Neck Surg. 2000;122:139–142
  13. Margaret BG, Miriam ST, Carol ML, et al. Oral squamous cell carcinoma. Histologic risk assessment, but no margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–178
  14. Liao CT, Chang Joseph TC, Wang HM, et al. Does adjuvant radiation therapy improve outcome in pT1-3N0 oral cavity cancer with tumor-tree margins and perineural invasion?. Int J Radiat Oncol Biol Phys. 2008;71:371–376

PII: S1368-8375(09)00947-6

doi: 10.1016/j.oraloncology.2009.10.011

Oral Oncology
Volume 46, Issue 1 , Pages 49-55 , January 2010

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