Oral Oncology
Volume 46, Issue 1 , Pages 14-18 , January 2010

Paraneoplastic syndromes in patients with oral cancer

  • C. Toro

      Affiliations

    • Department of Surgical Sciences, Maxillofacial Surgery Clinic, University-Hospital of Udine, Udine, Italy
    • Corresponding Author InformationCorresponding author. Address: Maxillofacial Surgery Clinic, University-Hospital “S. Maria della Misericordia” of Udine, P.le S. Maria della Misericordia, 33100 Udine, Italy. Tel.: +39 (0) 432/559455; fax: +39 (0) 432/559868.
    • ,
  • A. Rinaldo

      Affiliations

    • Department of Surgical Sciences, ENT Clinic, University-Hospital of Udine, Udine, Italy
    • ,
  • C.E. Silver

      Affiliations

    • Departments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA
    • ,
  • M. Politi

      Affiliations

    • Department of Surgical Sciences, Maxillofacial Surgery Clinic, University-Hospital of Udine, Udine, Italy
    • ,
  • A. Ferlito

      Affiliations

    • Department of Surgical Sciences, ENT Clinic, University-Hospital of Udine, Udine, Italy

Received 21 September 2009 ,Revised 29 September 2009 ,Accepted 30 September 2009.

References 

  1. Ferlito A, Elsheikh MN, Manni JJ, Rinaldo A. Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol. 2007;264:211–222
  2. Yoo M, Bediako EO, Akca O. Syndrome of inappropriate antidiuretic hormone (SIADH) secretion caused by squamous cell carcinoma of the nasopharynx: case report. Clin Exp Otorhinolaryngol. 2008;1:110–112
  3. Zuffa M, Kubancok J, Rusnák I, Mensatoris K, Horváth A. Early paraneoplastic syndrome in medical oncology: clinicopathological analysis of 1694 patients treated over 20 years. Neoplasma. 1984;31:231–236
  4. Ferlito A, Rinaldo A. Paraneoplastic syndromes in patients with laryngeal and hypopharyngeal cancers. Ann Otol Rhinol Laryngol. 2000;109:109–117
  5. Toro C, Rinaldo A, Silver CE, Politi M, Ferlito A. Paraneoplastic syndromes in patients with nasopharyngeal cancer. Auris Nasus Larynx. 2009;36:513–520
  6. Iwase M, Kurachi Y, Kakuta S, Sakamaki H, Nakamura-Mitsuhashi M, Nagumo M. Hypercalcemia in patients with oral squamous cell carcinoma. Clin Oral Investig. 2001;5:194–198
  7. Iwase M, Takemi T, Manabe M, Nagumo M. Hypercalcemic complication in patients with oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2003;32:174–180
  8. Ferlito A, Rinaldo A, Devaney KO. Syndrome of inappropriate antidiuretic hormone secretion associated with head and neck cancers: review of the literature. Ann Otol Rhinol Laryngol. 1997;106:878–883
  9. Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957;23:529–542
  10. Zohar Y, Talmi YP, Finkelstein Y, Nobel M, Gafter U. Syndrome of inappropriate antidiuretic hormone secretion in cancer of the head and neck. Ann Otol Rhinol Laryngol. 1991;100:341–344
  11. Talmi YP, Hoffman HT, McCabe BF. Syndrome of inappropriate secretion of arginine vasopressin in patients with cancer of the head and neck. Ann Otol Rhinol Laryngol. 1992;101:946–949
  12. Okutomi T, Sakata S, Tatematsu N, Oka N. Squamous cell carcinoma of tongue and floor of mouth associated with syndrome of inappropriate secretion of antidiuretic hormone. J Oral Maxillofac Surg. 1987;45:447–449
  13. Abdi EA, Bishop S. The syndrome of inappropriate antidiuretic hormone secretion with carcinoma of the tongue. Med Pediatr Oncol. 1988;16:210–215
  14. Thompson M, Adlam DM. Syndrome of inappropriate antidiuretic hormone secretion associated with oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2002;40:216–219
  15. Hayes DF, Lechan RM, Posner MR, Weichselbaum RR, Miller D, Ervin TJ. The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck. J Surg Oncol. 1986;32:150–152
  16. Wenig BL, Heller KS. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following neck dissection. Laryngoscope. 1987;97:467–470
  17. McQuarrie DG, Mayberg M, Ferguson M, Shons A. A physiologic approach to the problems of simultaneous bilateral neck dissection. Am J Surg. 1977;134:455–460
  18. Zerbe R, Stropes L, Robertson G. Vasopressin function in the syndrome of inappropriate antidiuresis. Annu Rev Med. 1980;31:315–327
  19. Sridhar KS, Hussein AM. Hypercalcemia in head and neck squamous-cell carcinoma. Am J Clin Oncol. 1990;13:388–393
  20. Bradley PJ, Hoskin D. Hypercalcaemia in head and neck squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg. 2006;14:51–54
  21. Won C, Decker DA, Drelichman A, Al-Sarraf M, Reed ML. Hypercalcemia in head and neck carcinoma. Incidence and prognosis. Cancer. 1983;52:2261–2263
  22. Takagi M, Kayano T, Yamamoto H, Shibuya H, Hoshina M, Shioda S, et al. Causes of oral tongue cancer treatment failures. Analysis of autopsy cases. Cancer. 1992;69:1081–1087
  23. Penel N, Berthon C, Everard F, Neu JC, Clisant S, N’guyen M, et al. Prognosis of hypercalcemia in aerodigestive tract cancers: study of 136 recent cases. Oral Oncol. 2005;41:884–889
  24. Pande SB, Anil K, Khatri S, Rao RR. Paraneoplastic hypercalcaemia in advanced carcinoma of oral cavity. Ind J Med Ped Oncol. 2007;28:44–46
  25. Dunne FP, Bowden SJ, Brown JS, Ratcliffe WA, Browne RM. Parathyroid hormone related protein in oral squamous cell carcinomas invading the mandible. J Clin Pathol. 1995;48:300–303
  26. Gavrila A, Hasinski S, Rose LI. Hypercalcemia associated with squamous cell carcinoma of tongue. Endocr Pract. 2001;7:459–462
  27. Rikimaru K, Matsumoto F, Hayashi E, Bando H, Nagayama M. Evaluation of serum concentration of parathyroid hormone-related protein and its implication in hypercalcemia in squamous cell carcinoma of the head and neck. Int J Oral Maxillofac Surg. 1995;24:365–368
  28. Ansari K, Clerk A, Patel MH, Sainani A, Shastry PS, Advani SH. Hypercalcemia induced by parathyroid hormone-related peptide after treatment of squamous cell carcinoma of oral cavity. J Assoc Physicians India. 2003;51:1023–1024
  29. Gover A, Kumar PD, Brown LA, Ravakhah K. Hypercalcemia induced by parathyroid hormone-related peptide after treatment of carcinoma. South Med J. 2002;95:258–260
  30. Yoneda T, Nishimura R, Kato I, Ohmae M, Takita M, Sakuda M. Frequency of the hypercalcemia–leukocytosis syndrome in oral malignancies. Cancer. 1991;68:617–622
  31. Yoneda T, Nishikawa N, Nishimura R, Kato I, Sakuda M. Three cases of oral squamous cancer associated with leukocytosis, hypercalcemia, or both. Oral Surg Oral Med Oral Pathol. 1989;68:604–611
  32. Yoneda T, Aufdemorte TB, Nishimura R, Nishikawa N, Sakuda M, Alsina MM, et al. Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice. a novel experimental model of three concomitant paraneoplastic syndromes. J Clin Oncol. 1991;9:468–477
  33. Scheuermann K, Delank KW. Paraneoplastische Syndrome in der HNO-Heilkunde. HNO. 2003;51:332–336
  34. Kiliç A. Gül Ü, Soylu S. Skin findings in internal malignant diseases. Int J Dermatol. 2007;46:1055–1060
  35. Gougerot H, Grupper C. Dermatose érythémato-squameuse avec hyperkératose palmoplantaire, porectasies digitales et cancer de la langue latent. Paris Med. 1922;43:234–237
  36. Bazex A, Salvador R, Dupré A, Christol B. Syndrome paranéoplasique à type d’hyperkératose des extrémités. Guérison après le traitement de l’épithélioma laryngé. Bull Soc Fr Dermatol Syphiligr. 1965;72:182
  37. Bolognia JL, Brewer YP, Cooper DL. Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991;70:269–280
  38. Sarkar B, Knecht R, Sarkar C, Weidauer H. Bazex syndrome (acrokeratosis paraneoplastica). Eur Arch Otorhinolaryngol. 1998;255:205–210
  39. Buxtorf K, Hübscher E, Panizzon R. Bazex syndrome. Dermatology. 2001;202:350–352
  40. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349–356
  41. Cohen PR, Holder WR, Tucker SB, Kono S, Kurzrock R. Sweet syndrome in patients with solid tumors. Cancer. 1993;72:2723–2731
  42. van der Meij EH, Epstein JB, Hay J, Ho V, Lerner K. Sweet’s syndrome in a patient with oral cancer associated with radiotherapy. Eur J Cancer B Oral Oncol. 1996;32B:133–136
  43. Giménez-Arnau A, Carles J, Pla-Ferrer C, Barranco CM, Fontané J, Camarasa JG. Sweet’s syndrome and malignancy: a case associated with multiple oral squamous-cell carcinoma. Dermatology. 1996;193:154–155
  44. Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA, Kory M, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med. 1990;323:1729–1735
  45. Kaplan I, Hodak E, Ackerman L, Mimouni D, Anhalt GJ, Calderon S. Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations. Oral Oncol. 2004;40:553–562
  46. Camisa C, Helm TN. Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch Dermatol. 1993;129:883–886
  47. van der Waal RI, Pas HH, Anhalt GJ, Schulten EA, Jonkman MF, Nieboer C. Paraneoplastic pemphigus as the presenting symptom of a lymphoma of the tongue. Oral Oncol. 1998;34:567–570
  48. Wong KC, Ho KK. Pemphigus with pemphigoid-like presentation, associated with squamous cell carcinoma of the tongue. Australas J Dermatol. 2000;41:178–180
  49. de Souza Azevedo R, Abrahão AC, de Albuquerque EB. Synchronous orofacial granulomatosis and mucoepidermoid carcinoma: paraneoplastic syndrome or coincidence?. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e40–e45

PII: S1368-8375(09)00937-3

doi: 10.1016/j.oraloncology.2009.09.007

Oral Oncology
Volume 46, Issue 1 , Pages 14-18 , January 2010

Article Tools