Review of the molecular pathogenesis of the odontogenic keratocyst
Received 13 July 2009; received in revised form 1 August 2009; accepted 17 August 2009. published online 05 October 2009.
Summary
The odontogenic keratocyst (keratocystic odontogenic tumour) (OKC) is one of the most prevalent odontogenic tumours. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. In this review the authors address the main genetic and epigenetic alterations reported on this tumour. Although most of the knowledge on this field is not being used in the clinical practice, some perspectives of translational studies are discussed.
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Corresponding author. Address: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, MG, CEP 31270 901, Brazil. Tel.: +55 31 34092477; fax: +55 31 34092430.
ABSTRACT