Oral Oncology
Volume 45, Issue 12 , Pages e245-e248 , December 2009

Acetaldehyde production from ethanol and glucose by non-Candida albicans yeasts in vitro

  • Mikko T. Nieminen

      Affiliations

    • Research Unit on Acetaldehyde and Cancer, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    • Department of Oral Medicine, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    • ,
  • Johanna Uittamo

      Affiliations

    • Research Unit on Acetaldehyde and Cancer, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    • Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    • ,
  • Mikko Salaspuro

      Affiliations

    • Research Unit on Acetaldehyde and Cancer, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    • ,
  • Riina Rautemaa

      Affiliations

    • Department of Oral Medicine, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    • Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    • Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland
    • The University of Manchester, Manchester Academic Health Science Centre, School of Translational Medicine and University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    • Corresponding Author InformationCorresponding author. Address: Education and Research Centre, 2nd Floor, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK. Tel.: +44 75 4599 4959; fax: +44 161 291 5806.

Received 17 July 2009 ,Revised 5 August 2009 ,Accepted 5 August 2009.

References 

  1. Pelucchi C, Gallus S, Garavello W, Bosetti C, La Vecchia C. Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. Eur J Cancer Prev. 2008;17:340–344
  2. La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and prevention of oral cancer. Oral Oncol. 1997;33:302–312
  3. Salaspuro MP. Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Sci. 2003;40:183–208
  4. World Health Organisation. IARC monographs on the evaluation of carcinogenicrisks to humans: re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide, vol. 71. Lyon, France; 1999.
  5. Boccia S, Hashibe M, Galli P, De Feo E, Asakage T, Hashimoto T, et al. Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a mendelian randomization approach. Cancer Epidemiol Biomarkers Prev. 2009;18:248–254
  6. Salaspuro M. Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. Scand J Gastroenterol. 2009;44:912–925
  7. Brooks PJ, Theruvathu JA. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol. 2005;35:187–193
  8. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Rev Cancer. 2007;7:599–612
  9. Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis. 1997;18:1739–1743
  10. Salaspuro M. Microbial metabolism of ethanol and acetaldehyde and clinical consequences. Addict Biol. 1996;2:35–46
  11. Linderborg K, Joly JP, Visapää JP, Salaspuro M. Potential mechanism for Calvados-related oesophageal cancer. Food Chem Toxicol. 2008;46:476–479
  12. Lachenmeier DW, Kanteres F, Rehm J. Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. Addiction. 2009;104:533–550
  13. Muto M, Hitomi Y, Ohtsu A, Shimada H, Kashiwase Y, Sasaki H, et al. Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: implications for carcinogenesis in upper aerodigestive tract. Int J Cancer. 2000;88:342–350
  14. Kurkivuori J, Salaspuro V, Kaihovaara P, Kari K, Rautemaa R, Grönroos L, et al. Acetaldehyde production from ethanol by oral streptococci. Oral Oncol. 2007;43:181–186
  15. Tillonen J, Homann N, Rautio M, Jousimies-Somer H, Salaspuro M. Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. Alcohol Clin Exp Res. 1999;23:1409–1415
  16. Uittamo J, Siikala E, Kaihovaara P, Salaspuro M, Rautemaa R. Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans. Int J Cancer. 2009;124:754–756
  17. Richardson MD WD. Fungal infection: diagnosis and management. 3rd ed.. Oxford: Blackwell; 2003;
  18. Rautemaa R, Rusanen P, Richardson M, Meurman JH. Optimal sampling site for mucosal candidosis in oral cancer patients is the labial sulcus. J Med Microbiol. 2006;55:1447–1451
  19. Rautemaa R, Hietanen J, Niissalo S, Pirinen S, Perheentupa J. Oral and oesophageal squamous cell carcinoma – a complication or component of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED, APS-I). Oral Oncol. 2007;43:607–613
  20. Salaspuro V, Hietala J, Kaihovaara P, Pihlajarinne L, Marvola M, Salaspuro M. Removal of acetaldehyde from saliva by a slow-release buccal tablet of l-cysteine. Int J Cancer. 2002;97:361–364
  21. Homann N, Karkkainen P, Koivisto T, Nosova T, Jokelainen K, Salaspuro M. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst. 1997;89:1692–1697
  22. Samaranayake LP, Keung Leung W, Jin L. Oral mucosal fungal infections. Periodontol. 2009;49:39–59
  23. Davies AN, Brailsford S, Broadley K, Beighton D. Oral yeast carriage in patients with advanced cancer. Oral Microbiol Immunol. 2002;17:79–84
  24. Bagg J, Sweeney MP, Lewis MA, Jackson MS, Coleman D, Al MA, et al. High prevalence of non-albicans yeasts and detection of anti-fungal resistance in the oral flora of patients with advanced cancer. Palliat Med. 2003;17:477–481

PII: S1368-8375(09)00879-3

doi: 10.1016/j.oraloncology.2009.08.002

Oral Oncology
Volume 45, Issue 12 , Pages e245-e248 , December 2009

Article Tools

* Image Usage & Resolution