Oral Oncology
Volume 45, Issue 1 , Pages 16-22 , January 2009

Combined effects of MDM2 SNP 309 and p53 mutation on oral squamous cell carcinomas associated with areca quid chewing

  • Shiang-Fu Huang

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
    • Graduate Institute of Clinical Medical Science, Chang Gung University, Tao-Yuan, Taiwan
    • Taipei CGMH Head and Neck Oncology Group, Tao-Yuan, Taiwan
    • ,
  • I.-How Chen

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
    • Taipei CGMH Head and Neck Oncology Group, Tao-Yuan, Taiwan
    • ,
  • Chun-Ta Liao

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
    • Taipei CGMH Head and Neck Oncology Group, Tao-Yuan, Taiwan
    • ,
  • Hung-Ming Wang

      Affiliations

    • Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan
    • Taipei CGMH Head and Neck Oncology Group, Tao-Yuan, Taiwan
    • ,
  • Saou-Hsing Liou

      Affiliations

    • Department of Public Health, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Ling-Ling Hsieh

      Affiliations

    • Department of Public Health, Chang Gung University, 259 Wen-Hwa 1 Road, Kwei-San, Tao-Yuan 333, Tao-Yuan, Taiwan
    • Taipei CGMH Head and Neck Oncology Group, Tao-Yuan, Taiwan
    • Corresponding Author InformationCorresponding author. Address: Department of Public Health, Chang Gung University, 259 Wen-Hwa 1 Road, Kwei-San, Tao-Yuan 333, Tao-Yuan, Taiwan. Tel.: +886 3 2118800x5125; fax: +886 3 2118700.

Received 5 February 2008 ,Accepted 12 March 2008.

References 

  1. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science. 1991;253:49–53
  2. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature. 1991;351:453–456
  3. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300–305
  4. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408:307–310
  5. Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000;14:981–993
  6. Mirza A, Wu Q, Wang L, McClanahan T, Bishop WR, Gheyas F, et al. Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression. Oncogene. 2003;22:3645–3654
  7. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994;54:4855–4878
  8. Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 2004;119:591–602
  9. Royds JA, Iacopetta B. p53 and disease: when the guardian angel fails. Cell Death Differ. 2006;13:1017–1026
  10. Menin C, Scaini MC, De Salvo GL, Biscuola M, Quaggio M, Esposito G, et al. Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst. 2006;98:285–288
  11. Boersma BJ, Howe TM, Goodman JE, Yfantis HG, Lee DH, Chanock SJ, et al. Association of breast cancer outcome with status of p53 and MDM2 SNP309. J Natl Cancer Inst. 2006;98:911–919
  12. Bond GL, Hirshfield KM, Kirchhoff T, Alexe G, Bond EE, Robins H, et al. MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res. 2006;66:5104–5110
  13. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med. 1995;24:450–453
  14. Duke JA. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL: CRC Press; 1992;
  15. Nunez-de la Mora A, Chatterton RT, Mateo ET, Jesmin F, Bentley GR. Effect of chewing betel nut on measurements of salivary progesterone and estradiol. Am J Phys Anthropol. 2007;132:311–315
  16. Hsieh LL, Chien HT, Chen IH, Liao CT, Wang HM, Jung SM, et al. The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas. Cancer Epidemiol Biomark Prev. 2003;12:439–443
  17. Hsieh LL, Liou SH, Chen YH, Tsai LC, Yang T, Wu TN. Association between aminolevulinate dehydrogenase genotype and blood lead levels in Taiwan. J Occup Environ Med. 2000;42:151–155
  18. Liao HK, Su YN, Kao HY, Hung CC, Wang HT, Chen YJ. Parallel minisequencing followed by multiplex matrix-assisted laser desorption/ionization mass spectrometry assay for beta-thalassemia mutations. J Human Genet. 2005;50:139–150
  19. Stanssens P, Zabeau M, Meersseman G, Remes G, Gansemans Y, Storm N, et al. High-throughput MALDI-TOF discovery of genomic sequence polymorphisms. Genome Res. 2004;14:126–133
  20. Hsieh LL, Wang PF, Chen IH, Liao CT, Wang HM, Chen MC, et al. Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese. Carcinogenesis. 2001;22:1497–1503
  21. Hsieh LL, Huang TH, Chen IH, Liao CT, Wang HM, Lai CH, et al. p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan. Brit J Cancer. 2005;92:30–35
  22. Stoll C, Baretton G, Lohrs U. The influence of p53 and associated factors on the outcome of patients with oral squamous cell carcinoma. Virchows Arch. 1998;433:427–433
  23. Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci USA. 1998;95:15608–15612
  24. Ganguli G, Abecassis J, Wasylyk B. MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 2000;19:5135–5147
  25. Hong Y, Miao X, Zhang X, Ding F, Luo A, Guo Y, et al. The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma. Cancer Res. 2005;65:9582–9587
  26. Dazard JE, Piette J, Basset-Seguin N, Blanchard JM, Gandarillas A. Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size. Oncogene. 2000;19:3693–3705
  27. Myers JN, Greenberg JS, Mo V, Roberts D. Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer. 2001;92:3030–3036
  28. Carter RL, Barr LC, O’Brien CJ, Soo KC, Shaw HJ. Transcapsular spread of metastatic squamous cell carcinoma from cervical lymph nodes. Am J Surg. 1985;150:495–499
  29. Agarwal S, Mathur M, Srivastava A, Ralhan R. MDM2/p53 co-expression in oral premalignant and malignant lesions: potential prognostic implications. Oral Oncol. 1999;35:209–216
  30. Zhou G, Zhai Y, Cui Y, Zhang X, Dong X, Yang H, et al. MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population. Clin Cancer Res. 2007;13:2627–2633
  31. Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res. 2004;64:4180–4189
  32. Zietz C, Rossle M, Haas C, Sendelhofert A, Hirschmann A, Sturzl M, et al. MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol. 1998;153:1425–1433
  33. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 1995;55:3964–3968
  34. Ozdemir E, Kakehi Y, Okuno H, Habuchi T, Okada Y, Yoshida O. Strong correlation of basement membrane degradation with p53 inactivation and/or MDM2 overexpression in superficial urothelial carcinomas. J Urol. 1997;158:206–211
  35. Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol. 2003;13:49–58
  36. Brennan P. Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it?. Carcinogenesis. 2002;23:381–387
  37. de Oliveira LR, Ribeiro-Silva A, Zucoloto S. Prognostic impact of p53 and p63 immunoexpression in oral squamous cell carcinoma. J Oral Pathol Med. 2007;36:191–197
  38. Gonzalez-Moles MA, Galindo P, Gutierrez-Fernandez J, Sanchez-Fernandez E, Rodriguez-Archilla A, Ruiz-Avila I, et al. P53 protein expression in oral squamous cell carcinoma. survival analysis. Anticancer Res. 2001;21:2889–2894
  39. Ralhan R, Sandhya A, Meera M, Bohdan W, Nootan SK. Induction of MDM2-P2 transcripts correlates with stabilized wild-type p53 in betel- and tobacco-related human oral cancer. Am J Pathol. 2000;157:587–596
  40. Liu CJ, Chang KW, Chao SY, Kwan PC, Chang SM, Yen RY, et al. The molecular markers for prognostic evaluation of areca-associated buccal squamous cell carcinoma. J Oral Pathol Med. 2004;33:327–334
  41. Arva NC, Gopen TR, Talbott KE, Campbell LE, Chicas A, White DE, et al. A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J Biol Chem. 2005;280:26776–26787
  42. Santarosa M, Ashworth A. Haploinsufficiency for tumour suppressor genes: when you don’t need to go all the way. Biochim Biophys Acta. 2004;1654:105–122
  43. Kondo S, Barnett GH, Hara H, Morimura T, Takeuchi J. MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene. 1995;10:2001–2006
  44. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004;303:844–848
  45. Chene P. Inhibition of the p53-MDM2 interaction: targeting a protein–protein interface. Mol Cancer Res. 2004;2:20–28

PII: S1368-8375(08)00091-2

doi: 10.1016/j.oraloncology.2008.03.006

Oral Oncology
Volume 45, Issue 1 , Pages 16-22 , January 2009

Article Tools

* Image Usage & Resolution