Oral Oncology
Volume 40, Issue 8 , Pages 811-814 , September 2004

Severe oral chronic graft-versus-host disease following allogeneic bone marrow transplantation: highly effective treatment with topical tacrolimus

  • André Eckardt

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-511-532-4878; fax: +49-511-532-8879
    • ,
  • Oliver Starke

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • ,
  • Michael Stadler

      Affiliations

    • Department of Hematology, Hemostaseology and Oncology, Bone Marrow Transplantation Unit, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • ,
  • Christoph Reuter

      Affiliations

    • Department of Hematology, Hemostaseology and Oncology, Bone Marrow Transplantation Unit, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • ,
  • Bernd Hertenstein

      Affiliations

    • Department of Hematology, Hemostaseology and Oncology, Bone Marrow Transplantation Unit, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany

Received 2 February 2004 ,Accepted 5 February 2004.

References 

  1. Ratanatharathorn V, Ayash L, Lazarus HM, Fu J, Uberti FU. Chronic graft-versus-host disease: clinical manifestations and therapy. Bone Marrow Transpl. 2001;28:121–129
  2. Nicolatou-Galitis O, Kitra V, Van Vliet-Constantinidou C, Peristeri J, Goussetis E, Petropoulos D, et al.  The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients. J. Oral Pathol. Med. 2001;30:148–153
  3. Demarosi F, Bez C, Sardella A, Lodi G, Carrassi A. Oral involvement in chronic graft-vs-host disease following allogeneic bone marrow transplantation. Arch. Dermatol. 2002;138:842–843
  4. Epstein JB, Nantel S, Sheoltch SM. Topical azathioprine in the combined treatment of chronic oral graft-versus-host disease. Bone Marrow Transpl. 2000;25:683–687
  5. Redding SW, Callander NS, Haveman CW, Leonard DL. Treatment of oral chronic graft-versus-host disease with PUVA therapy. Case report and literature review. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1998;85:183–187
  6. Ruzicka T, Bieber T, Schöpf E, et al.  A short-term trial of tacrolimus ointment for atopic dermatitis. New England J. Med. 1997;337:816–821
  7. Olivier V, Lacour JP, Mousnier A, Garaffo R, Monteil RA, Ortonne JP. Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus. Arch. Dermatol. 2002;138:1335–1338
  8. Elad S, Or R, Resnick I, Shapira MY. Topical tacrolimus––a novel treatment alternative for cutaneous chronic graft-versus-host-disease. Transpl. Int. 2003;16:665–670
  9. Morrison L, Kratochvil FJ, Gorman A. An open trial of topical tacrolimus for erosive oral lichen planus. J. Am. Acad. Dermatol. 2002;47:617–620
  10. Hasséus B, Jontell M, Brune M, Johansson P, Dahlgren UI. Langerhans cells and T cells in oral graft versus host disease and oral lichen planus. Scand. J. Immunol. 2001;54:516–524
  11. Nakamura S, Hiroki A, Shinohara M, Gondo H, Ohyama Y, Mouri T, et al.  Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1996;82:556–563
  12. Fujiwara K, Sakai Y, Sugiura J, Yamasaki A. Oral mucosal lesions in experimental graft-versus-host disease: morphological and immunohistochemical characterization of infiltrating cells. J. Oral Pathol. Med. 1996;25:314–319

PII: S1368-8375(04)00048-X

doi: 10.1016/j.oraloncology.2004.02.003

Oral Oncology
Volume 40, Issue 8 , Pages 811-814 , September 2004

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