Oral Oncology
Volume 40, Issue 8 , Pages 804-810, September 2004

Expression of tumor necrosis factor-alpha and its soluble receptors in betel-quid-chewing patients at different stages of treatment for oral squamous cell carcinoma

  • Tzu-Rong Su

      Affiliations

    • Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    • Tian-Sheng Memorial Hospital, Tong-Kang 928, Taiwan
    • ,
  • Kee-Lung Chang

      Affiliations

    • Department of Biochemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    • ,
  • Chien-Hung Lee

      Affiliations

    • Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    • ,
  • Chung-Ho Chen

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    • ,
  • Yi-Hsin Yang

      Affiliations

    • Graduate Institute of Oral Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    • ,
  • Tien-Yu Shieh

      Affiliations

    • Oral Health Research Center, Collage of Dental Medicine, Kaohsiung Medial University, No. 100 Shih-Chuan 1st Rd, Kaohsiung 807, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886-7-312-1101x2338; fax: +886-7-322-3870

Received 28 January 2004; accepted 3 February 2004.

Abstract 

Tumor necrosis factor-alpha (TNF-α) can inhibit tumor progression. It can be regulated by its soluble receptors (sTNF-Rs). We examined the expression of TNF-α and sTNF-Rs and the TNF-α/sTNF-R ratios in betel-quid-chewing patients with oral squamous cell carcinoma (OSCC) to see if these parameters are associated with disease progression according to the treatment stage. Peripheral blood mononuclear cells from 116 OSCC patients at different treatment stages and 19 betel-quid chewers with normal mucosa were assayed with ELISA. Levels of sTNF-RII in the OSCC patients were significantly higher than normal controls, with the recurrence group having the highest levels. After controlling for age and use of alcohol and tobacco, the TNF-α/sTNF-RII ratio showed significant differences comparing OSCC patients at each treatment stage with normal controls. Our results suggest that sTNF-RII and TNF-α/sTNF-RII ratio may be informative for the diagnosis and prognosis of OSCC.

Keywords:  Betel quid, Oral squamous cell carcinoma, Soluble tumor necrosis factor receptors, Peripheral blood mononuclear cells, Treatment stages, Tumor necrosis factor-alpha

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PII: S1368-8375(04)00047-8

doi:10.1016/j.oraloncology.2004.02.001

Oral Oncology
Volume 40, Issue 8 , Pages 804-810, September 2004

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