Oral Oncology
Volume 40, Issue 7 , Pages 720-727 , August 2004

Hamsters chewing betel quid or areca nut directly show a decrease in body weight and survival rates with concomitant epithelial hyperplasia of cheek pouch

  • Chun-Pin Chiang

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • ,
  • Mei-Chi Chang

      Affiliations

    • Team of Biomedical Science, Chang-Gung Institute of Technology, Taoyuan, Taiwan
    • ,
  • Jang-Jaer Lee

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • ,
  • Julia Yu-Fong Chang

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • ,
  • Po-Hsuen Lee

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • ,
  • Liang-Jiunn Hahn

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • ,
  • Jiiang-Huei Jeng

      Affiliations

    • Laboratory of Dental Pharmacology and Toxicology, Department of Dentistry, Graduate Institute of Clinical Dental Science, College of Medicine, National Taiwan University Hospital and National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan
    • Corresponding Author InformationCorresponding author. Fax: +886-2-238-21212

Received 18 December 2003 ,Accepted 15 January 2004.

References 

  1. Sharan RN. Association of betel nut with carcinogenesis. Cancer J. 1996;9:13–19
  2. Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J. Oral. Pathol. Med. 1995;24:450–453
  3. IARC. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 37, Lyon: International Agency for Research on Cancer; 1985
  4. Sen S, Talukder G, Sharma A. Betel cytotoxicity. J. Ethnopharmacol. 1989;26:217–247
  5. Jeng JH, Hahn LJ, Lin BR, Hsieh CC, Chan CP, Chang MC. Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J. Oral. Pathol. Med. 1999;28:64–71
  6. Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 2001;37:477–492
  7. Suri K, Goldman HM, Wells H. Carcinogenic effects of a dimethyl sulphozide extract of betel nut on the mucosa of the hamster buccal pouch. Nature. 1971;230:381–382
  8. Ranadive KJ, Gothoskar SV, Rao AR, Tezabwalla BU, Ambaye RY. Experimental studies on betel nut and tobacco carcinogenicity. Int. J. Cancer. 1976;17:469–476
  9. Jin YT, Tsai ST, Wong TY, Chen FF, Chen RMY. Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis. Eur. J. Cancer, Oral Oncol. 1996;32:343–346
  10. Kabat GC, Chang CJ, Wynder EL. The role of tobacco, alcohol use and body mass index in oral and pharyngeal cancer. Int. J. Epidemiol. 1994;23:1137–1144
  11. Deslypere JP. Obesity and cancer. Metabolism. 1995;44(Suppl.):24–27
  12. Hashibe M, Mathew B, Kuruvilla B, et al.  Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. Int. J. Cancer. 2000;88:129–134
  13. Hashibe M, Sankaranarayanan R, Thomas G, Kuruvilla B, Mathew B, Somanathan T, et al.  Body mass index, tobacco chewing, alcohol drinking and the risk of oral submucous fibrosis in Kerala, India. Cancer Causes Control. 2002;13:55–64
  14. Strickland SS, Duffield AE. Anthropometric status and resting metabolism rate in users of the areca nut and smokers of tobacco in rural Sarawak. Ann. Hum. Biol. 1997;24:453–474
  15. Vimokeasant S, Nakornchai S, Rungruangsak K, Dhanamitta S, Hilker DM. Food habits causing thiamine deficiency in humans. J. Nutr. Sci. Vitaminol. 1976;22(Suppl.):1–2
  16. Weegels P, Heywood P, Jenkins C. Consumption of betel nut and its possible contribution to protein and energy. Papua New Guinea Med. J. 1984;27:37–39
  17. Bhisey RA, Ramchandani AG, D'Souza AV, Borges AM, Notani PN. Long-term carcinogenicity of pan masala in swiss mice. Int. J. Cancer. 1999;83:679–684
  18. Sarma AB, Chakrabarti J, Chakrabarti A, Banerjee TS, Roy D, Mukherjee D, et al.  Evaluation of pan masala for toxic effects on liver and other organs. Food Chem. Toxicol. 1992;30:161–163
  19. Green PW, Simmonds MS, Blaney WM. Toxicity and behavioral effects of diet-born alkaloids on larvae of the black blowfly, Phormia regina. Med. Vet. Entomo. 2002;16:157–160
  20. Selvan RS, Venkateswaran KS, Rao AR. Influence of arecoline on immune system: I. Short term effect on general parameters and on the adrenal and lymphoid organs. Immunopharmacol. Immunotoxicol. 1989;11:347–377
  21. Nishikawa A, Prokopczyk B, Rivenson A, Zang E, Hoffmann D. A study of betel quid carcinogenesis: VIII. Carcinogenisity of 3-methylnitrosamino-propionaldehyde in F344 rats. Carcinogenesis. 1992;13:369–372
  22. Saikia M, Vaidehi MP. Studies on the pathological effects of feeding betel-nut meal in albino rats. Br. J. Exp. Pathol. 1983;64:515–517
  23. Kumar M, Kannan A, Upreti RK. Effect of betel/areca nut (Areca catechu) extracts on intestinal epithelial cell lining. Vet. Hum. Toxicol. 2000;42:257–260
  24. Jeng JH, Chen SY, Liao CH, Tung YY, Lin BR, Hahn LJ, et al.  Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. Free Radical Biol. Med. 2002;32:860–871
  25. Taylor RF, Al-Jarad N, John LM, Conroy DM, Barnes NC. Betel-nut chewing and asthma. Lancet. 1992;339:1134–1136
  26. Mannan N, Boucher BJ, Evans SJ. Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in east London. Br. J. Nutr. 2000;83:267–275
  27. Yang MS, Chung TC, Yang MJ, Hsu TY, Ko YC. Betel quid chewing and risk of adverse birth outcomes among aborigined in eastern Taiwan. J. Toxicol. Environ. Health (A). 2001;64:465–472
  28. Lin LM, Chen YK, Lai DR, Huang YL, Chen HR. Cancer-promoting effect of Taiwan betel quid in hamster buccal pouch carcinogenesis. Oral Dis. 1997;3:232–235
  29. Ranadive KJ, Ranadive SN, Shivapurkar NM, Gothoskar SV. Betel quid chewing and oral cancer: experimental studies on hamsters. Int. J. Cancer. 1979;24:835–843
  30. Rao AR. Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster. Int. J. Cancer. 1984;33:581–586
  31. Dunham LJ, Muir CS, Hamner JE. Epithelial atypia in hamster cheek pouches treated repeatedly with calcium hydroxide. Br. J. Cancer. 1996;20:588–593
  32. Tanaka T, Mori H, Fujii M, Takahashi M, Hirono I. Carcinogenisity examination of betel quid. II. Effect of vitamin A deficiency on rats fed semipurified diet containing betel nut and calcium hydroxide. Nutr. Cancer. 1983;4:260–266
  33. Eckert RL, Crish JF, Robinson NA. The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol. Rev. 1997;77:397–424
  34. Chiang CP, Lan MJ, Liu BY, Wang JT, Leu JS, Hahn LJ, et al.  Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. Oral Oncol. 2000;36:353–359
  35. Sundgvist K, Grafstrom RC. Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. Int. J Cancer. 1992;52:305–310
  36. Furstenberger G, Schweizer J, Marks F. Development of phorbol ester responsiveness in neonatal mouse epidermis: correlation between hyperplastic response and sensitivity to first stage tumor promotion. Carcinogenesis. 1985;6:285–294
  37. Di Giovanni J. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 1992;54:63–128
  38. Muir CS, Waterhouse J, Maek T, Poweu J, Whelan S, editors. Cancer incidence in five continents, vol. 5. Lyon: IARC Scientific Publications 88. IARC; 1987
  39. Tsai JF, Chuang LY, Jeng JE, Ho MS, Hsieh MY, Lin ZY, et al.  Betel quid chewing as a risk factor for hepatocellular carcinoma: a case-control study. Br. J. Cancer. 2001;84:709–713
  40. Liu TY, Chen CL, Chang KW, Chu CH, Liu TY. Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report. CMAJ. 2000;162:359–360
  41. Parkin DM, Srivatanakul P, Khlat M, Chenvidhya P, Insiripong S, L'Abbe KA, et al.  Liver cancer in Thailand. I. A case-control study of cholangiocarcinoma. Int. J. Cancer. 1991;48:323–328
  42. Lipsky MM, Hinton DE, Klaunig JE, Trump HF. Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinoma. J. Natl. Cancer Inst. 1981;67:393–405
  43. Singh A, Rao AR. Effect of arecanut, a masticatory, on hepatic drug metabolizing enzymes––SH content and lipid peroxidation in lactating mothers and their suckling neonates. Cancer Lett. 1995;92:175–180
  44. Wang CK, Su HY, Lii CK. Chemical composition and toxicity of Taiwanese betel quid extract. Food Chem. Toxicol. 1999;37:135–144

PII: S1368-8375(04)00025-9

doi: 10.1016/j.oraloncology.2003.12.015

Oral Oncology
Volume 40, Issue 7 , Pages 720-727 , August 2004

Article Tools

* Image Usage & Resolution