Oral Oncology
Volume 40, Issue 8 , Pages 793-797, September 2004

Treatment results of oral verrucous carcinoma and its biological behavior

  • A Ogawa

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-19-651-5111; fax: +81-19-651-9164
    • ,
  • Y Fukuta

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • T Nakajima

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • S.M Kanno

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • A Obara

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • K Nakamura

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • H Mizuki

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1-3-27 Chuo-dori, Morioka 020-8505, Japan
    • ,
  • Y Takeda

      Affiliations

    • Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    • ,
  • M Satoh

      Affiliations

    • Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan

Received 8 December 2003; accepted 24 December 2003.

Abstract 

The biologic behavior of and optimal treatment for oral verrucous carcinoma (VC) remain controversial. We analyzed the clinicopathological characteristics of 12 patients with oral VC. Immunohistochemical techniques were used to evaluate p53 protein, CD44 variant 9, and proliferating cell nucleus antigen. The TNM classification (UICC, 1997) was T1 in 1 patient, T2 in 3, T3 in 4, and T4 in 4. All patients were classified as N0M0. Four patients were treated by surgery alone and 8 by surgery after chemotherapy, radiotherapy, or both. After surgery, two patients had primary recurrence of disease. Immunohistochemically, the proliferative activity of tumor cells as evaluated by proliferating cell nuclear antigen labeling index and p53 protein expression was similar in VC and well-differentiated squamous cell carcinoma. However, CD44 varient 9 expression was positive in 8 of 10 VC, suggesting that oral VC is associated with a low risk of lymph node metastasis. Positive CD44 variant 9 expression by most oral VCs, indicating a low risk of cervical lymph node metastasis, suggests that most cases can be controlled by surgical intervention.

Keywords:  Oral verrucous carcinoma, Treatment result, p53 Protein, CD44v9, PCNA

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1368-8375(04)00008-9

doi:10.1016/j.oraloncology.2004.01.008

Refers to erratum:

  • Erratum to “Treatment results of oral verrucous carcinoma and its biological behavior” [Oral Oncology 40 (2004) 793–797]

    A. Ogawa, Y. Fukuta, T. Nakajima, M. Kanno, A. Obara, K. Nakamura, H. Mizuki, Y. Takeda, M. Satoh
    Oral Oncology April 2005 (Vol. 41, Issue 4, Pages 436-438)

Oral Oncology
Volume 40, Issue 8 , Pages 793-797, September 2004

Article Tools

* Image Usage & Resolution