Oral Oncology
Volume 40, Issue 8 , Pages 787-792 , September 2004

Detection of photodynamic therapy-induced early apoptosis in human salivary gland tumor cells in vitro and in a mouse tumor model

  • Tadayoshi Kaneko

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-33342-6111, fax: +81-33342-1723
    • ,
  • Hiroshige Chiba

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    • ,
  • Takashi Yasuda

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    • ,
  • Kaoru Kusama

      Affiliations

    • Deparment of Oral Pathology, Meikai University School of Dentistry, Sakado, Saitama, Japan

Received 11 December 2003 ,Accepted 31 January 2004.

References 

  1. Noodt BB, Berg K, Stokke T, Peng Q, Nesland JM. Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light. Br. J. Cancer. 1999;79:72–81
  2. Susin SA, Zamzami N, Kroemer G. Mitochondria as regulators of apoptosis. Biochim. Biophys. Acta. 1998;1366:151–165
  3. Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J. Cell Biol. 1997;138:1379–1394
  4. Leers MPG, Kölgen W, Björklund V, et al.  Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J. Pathol. 1999;187:567–572
  5. Kusama K, Jiang Y, Toguchi M, et al.  Use of the monoclonal antibody M30 for detecting HSG cell apoptosis. Anticancer Res. 2000;20:151–154
  6. Kusama K, Jiang Y, Kaneko T, et al.  Immunohistochemical detection of cytokeratin 18 and its neo-epitope in human salivary glands and pleomorphic adenomas. Anticancer Res. 2000;20:2485–2488
  7. Kaneko T, Chiba H, Yasuda T, Kusama K. Detection of transplanted human salivary gland tumor cell apoptosis induced by photodynamic therapy. Hosp. Dent. 2003;15:41–43
  8. Berkovitz BKB, Barrett AW. Cytokeratin intermediate filaments in oral and odontogenic epithelia. Bull. Group Int. Rech. Sci. Stom. Odontol. 1998;40:4–23
  9. Aizawa K, Okunaka T, Ohtani T, et al.  Localization of mono-L-aspartyl chlorin e6 (NPe6) in mouse tissues. Photochem. Photobiol. 1987;46:789–793
  10. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of Programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493–501
  11. Institute of Laboratory Animal Resources . Guide for the care and use of laboratory animals. Washington: National Academy Press; 1996;

PII: S1368-8375(04)00004-1

doi: 10.1016/j.oraloncology.2004.01.007

Oral Oncology
Volume 40, Issue 8 , Pages 787-792 , September 2004

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