Oral Oncology
Volume 40, Issue 5 , Pages 520-524 , May 2004

Human papillomavirus type 16 E6 and E7 genotypes in head-and-neck carcinomas

  • Markus Hoffmann

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 14, D-24105 Kiel, Germany
    • ,
  • Claudia Lohrey

      Affiliations

    • German Cancer Research Centre, F060, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    • ,
  • Andreas Hunziker

      Affiliations

    • German Cancer Research Centre, V280, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    • ,
  • Tomas Kahn

      Affiliations

    • German Cancer Research Centre, F060, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    • Present address: Deutsche Bank AG, Expert Team Life Sciences, P7, 10-15, D-68161 Mannheim, Germany.
    • ,
  • Elisabeth Schwarz

      Affiliations

    • German Cancer Research Centre, F060, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-6221-424654; fax: +49-6221-424852

Received 24 October 2003 ,Accepted 29 October 2003.

References 

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  2. Paz IB, Cook N, Odom-Maryon T, Xie Y, Wilczynski SP. Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer’s tonsillar ring. Cancer. 1997;79(3):595–604
  3. Andl T, Kahn T, Pfuhl A, Nicola T, Erber R, Conradt C, et al.  Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res. 1998;58(1):5–13
  4. (a) Hoffmann M, Kahn T, Mahnke CG, Goeroegh T, Lippert BM, Werner JA. Prevalence of human papillomavirus in squamous cell carcinoma of the head and neck determined by polymerase chain reaction and Southern blot hybridization: proposal for optimized diagnostic requirements. Acta. Otolaryngol. (Stockh.). 1998;118:138–144 Hoffmann et al., in preparation
  5. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al.  Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J. Natl. Cancer Inst. 2000;92(9):709–720
  6. Mellin H, Friesland S, Lewensohn R, Dalianis T, Munck-Wikland E. Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int. J. Cancer. 2000;89(3):300–304
  7. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, et al.  Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001;92(11):2875–2884
  8. Li W, Thompson CH, O’Brien CJ, McNeil EB, Scolyer RA, Cossart YE, et al.  Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int. J. Cancer. 2003;106(4):553–558
  9. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer. 2002;2(5):342–350
  10. Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene. 2002;21:1510–1517
  11. van Houten VM, Snijders PJ, van den Brekel MW, Kummer JA, Meijer CJ, van Leeuwen B, et al.  Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int. J. Cancer. 2001;93(2):232–235
  12. Yamada T, Manos MM, Peto J, Greer CE, Munoz N, Bosch FX, et al.  Human papillomavirus type 16 sequence variations in cervical cancers: a worldwide perspective. J. Virol. 1997;71(3):2463–2472
  13. Walboomers JMM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al.  Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999;189:12–19
  14. Zehbe I, Wilander E, Delius H, Tommasino M. Human papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype. Cancer Res. 1998;58(4):829–833
  15. Zehbe I, Tachezy R, Mytilineos J, Voglino G, Mikyskova I, Delius H, et al.  Human papillomavirus 16 E6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class II haplotypes. Int. J. Cancer. 2001;94(5):711–716
  16. Kämmer C, Tommasino M, Syrjanen S, Delius H, Hebling U, Warthorst U, et al.  Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease. Br. J. Cancer. 2002;86(2):269–273
  17. Ellis JR, Keating PJ, Baird J, Hounsell EF, Renouf DV, Rowe M, et al.  The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer. Nat. Med. 1995;1(5):464–470
  18. Etherington IJ, Ellis JR, Luesley DM, Moffitt DD, Young LS. Histologic and immunologic associations of an HPV16 variant in LoSIL smears. Gynecol. Oncol. 1999;72(1):56–59

PII: S1368-8375(03)00233-1

doi: 10.1016/j.oraloncology.2003.10.011

Oral Oncology
Volume 40, Issue 5 , Pages 520-524 , May 2004

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