Oral Oncology
Volume 40, Issue 5 , Pages 496-500 , May 2004

Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma

  • Makiko Moriyama-Kita

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Kanazawa University, Graduate School of Medicine, 13-1 Takaramachi, Kanazawa 920-8640, Japan
    • Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934, Japan
    • Corresponding Author InformationCorresponding author. Address: Department of Oral and Maxillofacial Surgery, Kanazawa University, Graduate School of Medicine, 13-1 Takaramachi, Kanazawa 920-8640, Japan. Tel.: +81-76-265-2444; fax: +81-76-234-4522
  • ,
  • Yoshio Endo

      Affiliations

    • Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934, Japan
  • ,
  • Yutaka Yonemura

      Affiliations

    • Department of Gastric Cancer, Shizuoka Cancer Center, 1007 Shimo-nagakubo, Kagaizumimachi, Suntougun, Shizuoka 411-0934, Japan
  • ,
  • Claus W Heizmann

      Affiliations

    • Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich, Steinwiesstr. 75, CH-8032 Zürich, Switzerland
  • ,
  • Beat W Schäfer

      Affiliations

    • Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich, Steinwiesstr. 75, CH-8032 Zürich, Switzerland
  • ,
  • Takuma Sasaki

      Affiliations

    • Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934, Japan
  • ,
  • Etsuhide Yamamoto

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Kanazawa University, Graduate School of Medicine, 13-1 Takaramachi, Kanazawa 920-8640, Japan

Received 5 September 2003 ,Accepted 14 October 2003.

References 

  1. Moore BW. A soluble protein characteristic of the nervous system. Biochem. Biophys. Res. Commun. 1965;19:739–744
  2. Heizmann CW, Fritz G, Scäfer BW. S100 proteins: structure, functions and pathology. Front Biosci. 2002;7:d1356–1368
  3. Fritz G, Heizmann CW, 3D-structures of the Calcium- and Zinc binding S100 protein. In: Bode W, Messerschmidt A, Cygler M, editors., Handbook of Metalloproteins, vol 3 NY: John Wily & Sons, in press
  4. Parker C, Whittaker PA, Usmani BA, Lakshmi MS, Sherbet GV. Induction of 18A2/mts1 gene expression and its effects on metastasis and cell cycle control. DNA Cell Biol. 1994;13:1021–1028
  5. Selinfreund RH, Barger SW, Welsh MJ, Van Eldik LJ. Antisense inhibition of glial S100beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation. J. Cell. Biol. 1990;111:2021–2028
  6. Pedrocchi M, Schäfer BW, Mueller H, Eppenberger U, Heizmann CW. Expression of Ca(2+)-binding proteins of the S100 family in malignant human breast-cancer cell lines and biopsy samples. Int. J. Cancer. 1994;57:684–690
  7. Barraclough R. Calcium-binding protein S100A4 in health and disease. Biochim. Biophys. Acta. 1998;1448:190–199
  8. Ilg EC, Schäfer BW, Heizmann CW. Expression pattern of S100 calcium-binding proteins in human tumors. Int. J. Cancer. 1996;68:325–332
  9. Takenaga K, Nakanishi H, Wada K, Suzuki M, Matsuzaki O, Matsuura A, et al.  Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. Clin. Cancer Res. 1997;3:2309–2316
  10. Lloyd BH, Platt-Higgins A, Rudland PS, Barraclough R. Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells. Oncogene. 1998;17:465–473
  11. Albertazzi E, Cajone F, Leone BE, Naguib RN, Lakshmi MS, Sherbet GV. Expression of metastasis-associated genes h-mts1 (S100A4) and nm23 in carcinoma of breast is related to disease progression. DNA Cell Biol. 1998;17:335–342
  12. Yonemura Y, Endou Y, Kimura K, Fushida S, Bandou E, Taniguchi K, et al.  Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer. Clin. Cancer Res. 2000;6(11):4234–4242
  13. Kimura K, Endo Y, Yonemura Y, Heizmann CW, Schäfer BW, Watanabe Y, et al.  Clinical significance of S100A4 and E-cadherin-related adhesion molecules in non-small cell lung cancer. Int. J. Oncol. 2000;16:1125–1131
  14. Ninomiya I, Ohta T, Fushida S, Endo Y, Hashimoto T, Yagi M, et al.  Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma. Int. J. Oncol. 2001;18(4):715–720
  15. Yamamoto E, Kohama G, Sunakawa H, Iwai M, Hiratsuka H. Mode of invasion, bleomysin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity. Cancer. 1983;51:2175–2180
  16. Yamamoto E, Miyakawa A, Kohama G. Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg. 1984;6:938–947
  17. Bjørnland K, Winberg JO, Odegaard OT, Hovig E, Loennechen T, Aasen AO, et al.  S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. Cancer Res. 1999;59:4702–4708
  18. Endo H, Takenaga K, Kanno T, Satoh H, Mori S. Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4. J. Biol. Chem. 2002;277(29):26396–26402
  19. Vleminckx K, Vakaet L, Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991;66:107–119
  20. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, et al.  E-cadherin-mediated cell–cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 1991;113:173–185
  21. Schipper JH, Unger A, Jahnke K. E-cadherin as a functional marker of the differentiation and invasiveness of squamous cell carcinoma of the head and neck. Clin. Otolaryngol. 1994;19:381–384
  22. Shiozaki H, Oka H, Inoue M, Tamura S, Monden M. E-cadherin mediated adhesion system in cancer cells. Cancer. 1996;77:1605–1613
  23. Keirsebilck A, Bonne S, Bruyneel E, Vermassen P, Lukanidin E, Mareel M, et al.  E-cadherin and metastasin (mts-1/S100A4) expression levels are inversely regulated in two tumor cell families. Cancer Res. 1998;58:4587–4591

PII: S1368-8375(03)00227-6

doi: 10.1016/j.oraloncology.2003.10.003

Oral Oncology
Volume 40, Issue 5 , Pages 496-500 , May 2004