Oral Oncology
Volume 40, Issue 5 , Pages 474-482 , May 2004

Delivery of 10boron to oral squamous cell carcinoma using boronophenylalanine and borocaptate sodium for boron neutron capture therapy

  • Shigeki Obayashi

      Affiliations

    • Second Department of Oral and Maxillofacial Surgery Osaka University, Graduate School of Dentistry, Osaka 565-0871, Japan
    • ,
  • Itsuro Kato

      Affiliations

    • Second Department of Oral and Maxillofacial Surgery Osaka University, Graduate School of Dentistry, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-6-6879-2941; fax: +81-6-6876-5020
    • ,
  • Koji Ono

      Affiliations

    • Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan
    • ,
  • Shin-Ichiro Masunaga

      Affiliations

    • Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan
    • ,
  • Minoru Suzuki

      Affiliations

    • Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan
    • ,
  • Kenji Nagata

      Affiliations

    • Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan
    • ,
  • Yoshinori Sakurai

      Affiliations

    • Radiation Life Science, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan
    • ,
  • Yoshiaki Yura

      Affiliations

    • Second Department of Oral and Maxillofacial Surgery Osaka University, Graduate School of Dentistry, Osaka 565-0871, Japan

Received 23 July 2003 ,Accepted 25 September 2003.

References 

  1. Slatkin DN. A history of boron neutron capture therapy of brain tumours. Postulation of a brain radiation dose tolerance limit. Brain. 1991;114:1609–1629
  2. Barth R, Soloway AH, Fairchild RG, Brugger RM. Boron neutron capture therapy for cancer. Realities and prospects. Cancer. 1992;70:2995–3007
  3. Mishima Y, Honda C, Ichihashi M, Obara H, Hiratsuka J, Fukuda H, et al.  Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet. 1989;12:388–389
  4. Hatanaka H, Nakagawa Y. Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys. 1994;28:1061–1066
  5. Coderre JA, Morris GM, Micca PL, Fisher CD, Ross GA. Comparative assessment of single-dose and fractionated boron neutron capture therapy. Radiat. Res. 1995;144:310–317
  6. Coderre JA, Elowitz EH, Chadha M, Bergland R, Capala J, Joel DD, et al.  Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results. J. Neurooncol. 1997;33:141–152
  7. Chadha M, Capala J, Coderre JA, Elowitz EH, Iwai J, Joel DD, et al.  Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory. Int. J. Radiat. Oncol. Biol. Phys. 1998;40:829–834
  8. Khuri FR, Lippman SM, Spitz MR, Lotan R, Hong WK. Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J. Natl. Cancer Inst. 1997;89:199–211
  9. Smith BD, Haffty BG. Molecular markers as prognostic factors for local recurrence and radioresistance in head and neck squamous cell carcinoma. Radiat. Oncol. Invest. 1999;7:125–144
  10. Fu KK, Cooper JS, Marcial VA, Laramore GE, Pajak TF, Jacobs J, et al.  Evolution of the radiation therapy oncology group clinical trials for head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 1996;35:425–438
  11. Kastenbauer E, Wollenberg B. In search of new treatment methods for head-neck carcinoma. Laryngorhinootologie. 1999;78:31–35
  12. Coderre JA, Morris GM. The radiation biology of boron neutron capture therapy. Radiat. Res. 1999;151:1–18
  13. Fairchild RG. “Epithermal” neutron beam isodate charts in a phantom head. Radiology. 1965;85:555–564
  14. Moss RL, Aizawa O, Beynon D, Brugger R, Constantine G, Harling O, et al.  The requirements and development of neutron beams for neutron capture therapy of brain cancer. J. Neurooncol. 1997;33:27–40
  15. Kreimann EL, Itoiz ME, Longhino J, Blaumann H, Calzetta O, Schwint AE. Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model. Cancer Res. 2001;61:8638–8642
  16. Kreimann EL, Itoiz ME, Dagrosa A, Garavaglia R, Farias S, Batistoni D, et al.  The hamster cheek pouch as a model of oral cancer boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine. Cancer Res. 2001;61:8775–8781
  17. Ono K, Masunaga S, Kinashi Y, Takagaki M, Akaboshi M, Kobayashi T, et al.  Radiobiological evidence suggesting heterogenous microdistribution of boron compounds in tumors: its relation to quiescent cell population and tumor cure in neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys. 1996;34:1081–1086
  18. Ono K, Kinashi Y, Masunaga S, Suzuki M, Takagaki M. Electroporation increases the effect of boroncaptate (10B-BSH) in neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys. 1998;42:823–826
  19. Yanagie H, Tomita T, Kobayashi H, Fujii Y, Nonaka Y, Saegusa Y, et al.  Inhibition of human pancreatic cancer growth in nude mice by boron neutron capture therapy. Br. J. Cancer. 1997;75:660–665
  20. Pignol JP, Oudart H, Chauvel P, Sauerwein W, Gabel D, Prevot G. Selective delivery of 10B to soft tissue sarcoma using 10B-L-borophenylalanine for boron neutron capture therapy. Br. J. Radiol. 1998;71:320–323
  21. Ono K, Masunaga S, Suzuki M, Kinashi Y, Takagaki M, Akaboshi M. The combined effect of boronophenylalanine and borocaptate in boron neutron capture therapy for SCCVII tumors in mice. Int. J. Radiat. Oncol. Biol. Phys. 1999;43:431–436
  22. Miura M, Morris GM, Micca PL, Lombardo DT, Youngs KM, Kalef-Ezra JA, et al.  Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin. Radiat. Res. 2001;155:603–610
  23. Dagrosa MA, Viaggi M, Kreimann E, Farias S, Garavaglia R, Agote M, et al.  Selective uptake of p-boronophenylalanine by undifferentiated thyroid carcinoma for boron neutron capture therapy. Thyroid. 2002;12:7–12
  24. Hasina R, Matsumoto K, Matsumoto-Taniura N, Kato I, Sakuda M, Nakamura T. Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line. Br. J. Cancer. 1999;80:1708–1717
  25. Kobayashi T, Kanda K. Microanalysis of ppm-10B concentration in tissue for neutron capture therapy by prompt gamma-ray spectrometry. Nucl. Instrum. Methods. 1982;204:525–531
  26. Kinashi Y, Sakurai Y, Masunaga S, Takagaki M, Ono K. Sensitizing effect of the phosphatidylinositol 3-kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound. Radiat. Med. 2001;19:27–32
  27. Suzuki M, Masunaga Si , Kinashi Y, Takagaki M, Sakurai Y, Kobayashi T, et al.  The effects of boron neutron capture therapy on liver tumors and normal hepatocytes in mice. Jpn. J. Cancer Res. 2000;91:1058–1064
  28. Chanana AD, Capala J, Chadha M, Coderre JA, Diaz AZ, Elowitz EH, et al.  Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies. Neurosurgery. 1999;44:1182–1193
  29. Coderre JA, Glass JD, Fairchild RG, Roy U, Cohen S, Fand I. Selective targeting of boronophenylalanine to melanoma for neutron capture therapy. Cancer Res. 1987;47:6377–6383
  30. Coderre JA, Morris GM, Kalef-Ezra J, Micca PL, Ma R, Youngs K, et al.  The effects of boron neutron capture irradiation on oral mucosa: evaluation using a rat tongue model. Radiat. Res. 1999;152:113–118
  31. Fairchild RG, Slatkin DN, Coderre JA, Micca PL, Laster BH, Kahl SB, et al.  Optimization of boron and neuron delivery for neutron capture therapy. Pig Cell Res. 1989;2:309–318

PII: S1368-8375(03)00223-9

doi: 10.1016/j.oraloncology.2003.09.018

Oral Oncology
Volume 40, Issue 5 , Pages 474-482 , May 2004

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