Oral Oncology
Volume 40, Issue 1 , Pages 52-55, January 2004

GSTM1 polymorphism and oral squamous cell carcinoma

  • Sérgio Neves Drummond

      Affiliations

    • Departmento de Patologia e Cirurgia, Faculdade de Odontologia, Av. Antônio Carlos, 6627, Belo Horizonte, 31270-901, Brazil
    • ,
  • Luiz De Marco

      Affiliations

    • Pharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil
    • ,
  • Júlio Carlos Motta Noronha

      Affiliations

    • Departmento de Patologia e Cirurgia, Faculdade de Odontologia, Av. Antônio Carlos, 6627, Belo Horizonte, 31270-901, Brazil
    • ,
  • Ricardo Santiago Gomez

      Affiliations

    • Departmento de Patologia e Cirurgia, Faculdade de Odontologia, Av. Antônio Carlos, 6627, Belo Horizonte, 31270-901, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-31-34992477; fax: +55-31-34992472

Received 1 April 2003; received in revised form 23 April 2003; accepted 23 April 2003.

Abstract 

We investigated the frequency of the GSTM1 genotypes in 70 Brazilian patients with oral squamous cell carcinoma (OSCC) and 82 age-sex matched controls. The GSTM1 genotypes were studied by PCR-based methods. The frequency of male patients with OSCC and null for the GSTM1 (70.5%) was statistically different from the male patients from the control group (48.5%) (Odds Ratio, OR=2.53, 95% CI=1.22–5.24, P<0.05). The frequency of the GSTM1 null genotype (0/0) in the group with OSCC (65.7%) was statistically different from the controls (48.7%) (OR=2.01, 95% CI=1.04–3.88, P<0.05). The prevalence of GSTM1 deficiency (null) was significantly higher for patients with oral cancer of the floor of the mouth (OR=3.67, 95% CI=1.11–12.11, P<0.05). In conclusion, the GSTM1 null genotype may increase the risk for OSCC development.

Keywords:  Oral squamous cell carcinoma, GSTM1, Polymorphism

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PII: S1368-8375(03)00132-5

doi:10.1016/S1368-8375(03)00132-5

Oral Oncology
Volume 40, Issue 1 , Pages 52-55, January 2004

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