Oral Oncology
Volume 40, Issue 1 , Pages 28-35, January 2004

Expression of SGLT-1 in preneoplastic and neoplastic lesions of the head and neck

  • Burkhard M Helmke

      Affiliations

    • Department of Pathology, University of Heidelberg, INF 220, 69120 Heidelberg, Germany
    • The first two authors have contributed equally to this paper.
    • ,
  • Christoph Reisser

      Affiliations

    • Molecular Cell Biology Group, Department of Head and Neck Surgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    • The first two authors have contributed equally to this paper.
    • ,
  • Mario Idzkoe

      Affiliations

    • Molecular Cell Biology Group, Department of Head and Neck Surgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    • ,
  • Gerhard Dyckhoff

      Affiliations

    • Molecular Cell Biology Group, Department of Head and Neck Surgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    • ,
  • Christel Herold-Mende

      Affiliations

    • Molecular Cell Biology Group, Department of Head and Neck Surgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    • Molecular Biology Laboratory, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-6221-563-9504; fax: +49-6221-565362

Received 6 May 2003; accepted 27 May 2003.

Abstract 

Tumors show an increased glucose uptake that is mediated by glucose transport proteins. We have analyzed the expression of the sodium-dependent glucose co-transporters SGLT-1 and-2 in short-term cultures of squamous cell carcinomas of the head and neck (HNSCC) by RT-PCR. Distribution of the SGLT-1 protein in HNSCC tissues was investigated by immunohistochemistry. While we observed in 17/36 HNSCC short-term cultures the SGLT-1 mRNA, we found no SGLT-2 expression. SGLT-1 mRNA expression occurred preferentially in cultures originating from moderately and well differentiated HNSCC. In tumor tissues a heterogeneous SGLT-1 staining restricted to differentiated tumor cells was seen in 27/30 HNSCC analyzed. In normal mucosa SGLT-1 staining was also confined to differentiated compartments and lacked in dysplastic areas. Our data indicate a differentiation-dependent expression of SGLT-1 in HNSCC. This is important knowledge for the planning of glucose-targeting therapies and suggest SGLT-1 as a differentiation marker in head and neck tissues.

Keywords:  HNSCC, SGLT-1, GLUT, Squamous cell carcinomas, Head and neck tumors, Glucose transport

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PII: S1368-8375(03)00129-5

doi:10.1016/S1368-8375(03)00129-5

Refers to erratum:

  • “Expression of SGLT-1 in preneoplastic and neoplastic lesions of the head and neck” by B.M. Helmke, C. Reisser, M. Idzkoe, G. Dyckhoff, C. Herold-Mende Oral Oncology 40 (1) 28–35

    C Herold-Mende
    Oral Oncology July 2004 (Vol. 40, Issue 6, Page 654)

Oral Oncology
Volume 40, Issue 1 , Pages 28-35, January 2004

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