Oral Oncology
Volume 40, Issue 1 , Pages 21-27 , January 2004

Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas

  • Toru Yanagawa

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan
    • Corresponding Author InformationCorresponding author. Tel./Fax: +81-29-853-3052
    • ,
  • Ken Omura

      Affiliations

    • Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Hiroyuki Harada

      Affiliations

    • Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Kazuhiro Nakaso

      Affiliations

    • Division of Neurology, Faculty of Medicine, Tottori University, Tottori, Japan
    • ,
  • Satoshi Iwasa

      Affiliations

    • Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    • ,
  • Yumi Koyama

      Affiliations

    • Department of Clinical Pharmaceutics, College of Pharmacy, Nihon University, Funabashi, Japan
    • ,
  • Kojiro Onizawa

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan
    • ,
  • Hiroshi Yusa

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan
    • ,
  • Hiroshi Yoshida

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan

Received 12 May 2003 ,Accepted 27 May 2003.

References 

  1. Choi AM, Alam J. Heme oxygenase-1 (function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury). Am. J. Respir. Cell Mol. Biol. 1996;15(1):9–19
  2. Marilena G. New physiological importance of two classic residual products (carbon monoxide and bilirubin). Biochem Mol Med. 1997;61(2):136–142
  3. Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, et al.  Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res. 1999;85(8):663–671
  4. Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA. Biological and clinical implications of heat shock protein 27,000 (Hsp27) (a review). J Natl Cancer Inst. 1993;85(19):1558–1570
  5. Kawanishi K, Shiozaki H, Doki Y, Sakita I, Inoue M, Yano M, et al.  Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus. Cancer. 1999;85(8):1649–1657
  6. Takeno S, Noguchi T, Kikuchi R, Wada S, Sato T, Uchida Y. Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma. Oncol. Rep. 2001;8(3):585–590
  7. Nakajima M, Kuwano H, Miyazaki T, Masuda N, Kato H. Significant correlation between expression of heat shock proteins 27, 70 and lymphocyte infiltration in esophageal squamous cell carcinoma. Cancer Lett. 2002;178(1):99–106
  8. Kaur J, Srivastava A, Ralhan R. Expression of 70-kDa heat shock protein in oral lesions (marker of biological stress or pathogenicity). Oral Oncol. 1998;34(6):496–501
  9. Ito T, Kawabe R, Kurasono Y, Hara M, Kitamura H, Fujita K, et al.  Expression of heat shock proteins in squamous cell carcinoma of the tongue: an immunohistochemical study. J. Oral Pathol. Med. 1998;27(1):18–22
  10. Gandour-Edwards R, Trock BJ, Gumerlock P, Donald PJ. Heat shock protein and p53 expression in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 1998;118(5):610–615
  11. Leonardi R, Pannone G, Magro G, Kudo Y, Takata T, Lo Muzio L. Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncol. Rep. 2002;9(2):261–266
  12. Mese H, Sasaki A, Nakayama S, Yoshioka N, Yoshihama Y, Kishimoto K, et al.  Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma. Oncol. Rep. 2002;9(2):341–344
  13. Tsuji MH, Yanagawa T, Iwasa S, Tabuchi K, Onizawa K, Bannai S, et al.  Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis. Cancer Lett. 1999;138(1-2):53–59
  14. Sobin LH, Wittekind Ch. TNM classification of malignant tumours. 5th edition. New York: Wiley-Liss, Inc; 1997;
  15. Shintani S, Matsuura H, Hasegawa Y, Nakayama B, Fujimoto Y. The relationship of shape of tumor invasion to depth of invasion and cervical lymph node metastasis in squamous cell carcinoma of the tongue. Oncology. 1997;54(6):463–467
  16. Niimi M, Takashina M, Takami H, Ikeda Y, Shatari T, Hamano K, et al.  Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice. Surgery. 2000;128(6):910–917
  17. Soares MP, Lin Y, Anrather J, Csizmadia E, Takigami K, Sato K, et al.  Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med. 1998;4(9):1073–1077
  18. Kuwano A, Ikeda H, Takeda K, Nakai H, Kondo I, Shibahara S. Mapping of the human gene for inducible heme oxygenase to chromosome 22q12. Tohoku J Exp Med. 1994;172(4):389–392
  19. Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B. Chromosomal localization of the human heme oxygenase genes (heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13). 3. Genomics. 1994;20(3):513–516
  20. Poli-Frederico RC, Bergamo NA, Reis PP, Kowalski LP, Zielenska M, Squire JA, et al.  Chromosome 22q a frequent site of allele loss in head and neck carcinoma. Head Neck. 2000;22(6):585–590
  21. Miyakawa A, Wang XL, Nakanishi H, Imai FL, Shiiba M, Miya T, et al  Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13. Int J Oncol. 1998;13(4):705–709
  22. Yoshida H, Yusa H, Ueno E, Tohno E, Tsunoda-Shimizu H. Ultrasonographic evaluation of small cervical lymph nodes in head and neck cancer. Ultrasound Med Biol. 1998;24(5):621–629
  23. Takes RP, Baatenburg De Jong RJ, Alles MJ, Meeuwis CA, Marres HA, Knegt PP, et al.  Markers for nodal metastasis in head and neck squamous cell cancer. Arch Otolaryngol Head Neck Surg. 2002;128(5):512–518
  24. Tannapfel A, Weber A. Tumor markers in squamous cell carcinoma of the head and neck (clinical effectiveness and prognostic value). Eur Arch Otorhinolaryngol. 2001;258(2):83–88

PII: S1368-8375(03)00128-3

doi: 10.1016/S1368-8375(03)00128-3

Oral Oncology
Volume 40, Issue 1 , Pages 21-27 , January 2004

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