Oral Oncology
Volume 40, Issue 1 , Pages 13-20 , January 2004

Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma

Received 13 May 2003 ,Accepted 27 May 2003.

References 

  1. Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 2000;15:203–312
  2. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983;219:983–985
  3. Maglione D, Guerriero V, Viglietto AM, Delli-Bovi P, Persico MG. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc. Natl. Acad. Sci. U.S.A. 1991;88:9267–9271
  4. Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, et al.  Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 1996;93:2576–2581
  5. Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al.  A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996;15:290–298
  6. Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI. Vascular endothelial growth factor-related protein (a ligand and specific activator of the tyrosine kinase receptor Flt4). Proc. Natl. Acad. Sci. U.S.A. 1996;93:1988–1992
  7. Achen MG, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks AF, et al.  Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 1998;95:548–553
  8. Meyer M, Clauss M, Lepple-Wienhues A, Waltenberger J, Augustin HG, Ziche M, et al.  A novel vascular endothelial growth factor encoded by Orf virus VEGF-E, mediates angiogenesis via signalling through VEGFR 2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 1999;18:363–374
  9. Beck LJ, D'Amore P. Vascular development (cellular and molecular regulation). FASEB J. 1997;11:365–373
  10. Ellis L, Fidler I. Angiogenesis and metastasis. Eur J Cancer. 1996;32:2451–2460
  11. Nicosia RF. What is the role of vascular endothelial growth factor-related molecules in tumor angiogenesis?. Am J Pathol. 1998;153:11–16
  12. Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al.  A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996;15:290–298
  13. Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh V, Fang G, Dumont D, et al.  Expression of the fms-like tyrosine kinase 4 becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. U.S.A. 1995;92:3566–3570
  14. Tsurusaki T, Kanda S, Sakai H, Kanetake H, Saito Y, Alitalo K, et al. Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis. Br J Cancer. 1999;80:309–313
  15. Yonemura Y, Endo Y, Fujita H, Fushida S, Ninomiya I, Bandou E, et al.  Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer. Clin. Cancer Res. 1999;5:1823–1829
  16. Orlandini M, Marconcini L, Ferruzzi R, Oliviero S. Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. Proc. Natl. Acad. Sci. U.S.A. 1996;93:11675–11680
  17. Yamada Y, Nezu J, Shimane M, Hirata Y. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. Genomics. 1997;42:483–488
  18. Sobin LH, Fleming ID. TNM Classification of Malignant Tumors, fifth edition. Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer. 1997;80:1803–1804
  19. Wasi PN, Cohen B, Luthra UK, Torloni H. Histological typing of oral and oropharyngeal tumors. Geneva, WHO: International Histological Classification of Tumor; 1971;
  20. Anneroth G, Batsakis J, Lunba M. Reiew of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Sacnd J Dent Res. 1987;95:229–249
  21. Shih CH, Ozawa S, Ando N, Ueda M, Kitajima M. Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin. Cancer Res. 2000;6:1161–1168
  22. Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, et al.  Vascular endothelial growth factors VEGF-B and VEGF-C. J. Cell. Physiol. 1997;173:211–215
  23. Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson-Welsh L, Cao Y, et al.  Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J. 1997;16:3898–3911
  24. Stacker SA, Stenvers K, Caesar C, Vitali A, Domagala T, Nice E, et al.  Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. J. Biol. Chem. 1999;274:32127–32136
  25. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, et al.  The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 1991;266:11947–11954
  26. Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi BZ, et al. 121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J. Biol. Chem. 1995;270:11322–11326
  27. Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, et al.  Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 1996;93:2576–2581
  28. Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell. 1995;79:185–188
  29. Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, et al.  FTL4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 1992;52:5738–5743
  30. Salven P, Lymboussaki A, Heikkila P, Jaaskela-Saari H, Enholm B, Aase K, et al.  Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. Am J Pathol. 1998;153:103–108
  31. Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, et al.  Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science. 1997;276:1423–1425
  32. Oh SJ, Jeltsch MM, Birkenhager R, McCarthy JE, Weich HA, Christ B, et al.  V.E.G.F.and VEGF-C (specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane). Dev. Biol. 1997;188:96–109
  33. Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh VWM, Fang GH, Dumont D, et al.  Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. U.S.A. 1995;92:3566–3570
  34. Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, et al.  VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med. 2001;7:186–191
  35. Nakamura Y, Yasuoka H, Tsujimoto M, Yang Q, Imabun S, Nakahara M, et al.  Prognostic significance of vascular endothelial growth factor d in breast carcinoma with long-term follow-up. Clin. Cancer Res. 2003;9:716–721
  36. Niki T, Iba S, Tokunou M, Yamada T, Matsuno Y, Hirohashi S. Expression of vascular endothelial growth factors A, B, C, and D and their relationship to lymph node status in lung adenocarcinoma. Clin. Cancer Res. 2000;6:2431–2439

PII: S1368-8375(03)00127-1

doi: 10.1016/S1368-8375(03)00127-1

Oral Oncology
Volume 40, Issue 1 , Pages 13-20 , January 2004

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