Oral Oncology
Volume 39, Issue 5 , Pages 491-496 , July 2003

Histomorphologic and morphometric changes in minor salivary glands of the rat tongue during 4-nitroquinoline-1-oxide-induced carcinogenesis

  • Marilena Vered

      Affiliations

    • Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    • ,
  • Nitzan Daniel

      Affiliations

    • Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    • ,
  • Abraham Hirshberg

      Affiliations

    • Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    • ,
  • Dan Dayan

      Affiliations

    • Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972-3-640-9112; fax: +972-3-640-9250

Received 8 January 2003 ,Accepted 20 January 2003.

References 

  1. Takeda Y, Yamamoto H. Epithelial hyperplasia of the extra-glandular excretory ducts of human minor salivary glands (a histopathologic study). J Nihon Univ Sch Dent. 1997;39:147–153
  2. Daley TD, Lovas JG, Peters E, Wysocky GP, McGaw TW. Salivary gland duct involvement in oral epithelial dysplasia and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 1996;81:186–192
  3. Browne RM, Potts AJ. Dysplasia in salivary glands in sublingual leukoplakia and erythroplakia. Oral Surg Oral Med Oral Pathol. 1986;62:44–49
  4. Dayan D, Hirshberg A, Kaplan I, Rotem N, Bodner L. Experimental tongue cancer in desalivated rats. Oral Oncol. 1997;33:105–109
  5. Kaplan I, Engelberg J, Dayan D. The effect of desalivation on 4-nitroquinoline-1-oxide-induced tongue carcinogenesis (a morphometric study of nuclear organized regions). J Oral Pathol Med. 2001;30:48–52
  6. Hand AR. The fine structure of von Ebner's glands of the rat. J Cell Biol. 1970;44:340–353
  7. Nagato T, Ren XZ, Toh H, Tandler B. Ultrastructure of Weber's salivary glands of the root of the tongue in the rat. Anat Rec. 1997;249:435–440
  8. Chalkey HW. Method for the quantitative morphologic analysis of tissues. J Natl Cancer Ins. 1943;4:47–53
  9. Dayan D, Vered M, Paz T, Buchner A. Aging of human palatal salivary glands (a histomorphometric study). Exp Gerontol. 2000;35:85–93
  10. Dunnill MS. Quantitative methods in histology. In:  Dyce SC editors. Recent advances in clinical pathology. London: Churchill Livingstone; 1968;p. 402–405
  11. Mirzayans R, Bashir S, Murray D, Paterson MC. Inverse correlation between p53 and DNA repair efficiency in human fibroblast strains with 4-nitroquinoline 1-oxide (evidence that lesions other than DNA strand breaks trigger the p53 response). Carcinogenesis. 1999;20:941–946
  12. Sreebny LM, Broich G. Xerostomia (Dry mouth). In:  Sreebny LM editors. The salivary system. Boca Raton: CRC Press; 1987;p. 187
  13. Nagler RM. The enigmatic mechanism of irradiation-induced damage to the major salivary glands. Oral Diseases. 2002;8:141–416
  14. Sumitomo S, Hashimura K, Mori M. Growth pattern of experimental squamous cell carcinoma in rat submandibular glands—an immunohistochemical evaluation. Eur J Cancer B Oral Oncol. 1996;32:97–105
  15. Nair PM, Schroeder HE. Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity. Review. Immunology. 1986;57:171–180
  16. Ohne M, Satoh T, Yamada S, Takai H. Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water. Oral Surg Oral Med Oral Pathol. 1985;59:600–607
  17. Lekholm U, Wallenius K. Experimental oral cancer in rats with xerostomia. Odontol Revy. 1976;27:11–18
  18. Stormby NG, Wallenius K. Effect of reduced salivation on oral tumor induction in hamsters by 9,10-dimethyl-1,2-benzathracene. Odontol Revy. 1964;15:186–209
  19. Nishioki H, Nishi K, Kyokane K. Human saliva inactivates mutagenicity of carcinogens. Mutat Res. 1981;85:323–333

PII: S1368-8375(03)00011-3

doi: 10.1016/S1368-8375(03)00011-3

Oral Oncology
Volume 39, Issue 5 , Pages 491-496 , July 2003

Article Tools

* Image Usage & Resolution