Oral Oncology
Volume 39, Issue 5 , Pages 483-490, July 2003

Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype

  • Jong Y Park

      Affiliations

    • Divisions of Cancer Controls and Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, 12902 Magnolia Drive, Tampa, FL 33612, USA
    • Corresponding Author InformationCorresponding author. Fax: +1-813-632-1720
    • ,
  • Stimson P Schantz

      Affiliations

    • Department of Otolaryngology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    • ,
  • Philip Lazarus

      Affiliations

    • Divisions of Cancer Controls and Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, 12902 Magnolia Drive, Tampa, FL 33612, USA

Received 31 December 2002; accepted 7 January 2003.

Abstract 

The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles which are associated with altered EH activity and may be linked to increased risk for tobacco-related cancers. The objective was to examine the role of EH polymorphisms in orolaryngeal cancer risk. The prevalence of the EH codons 113 and 139 polymorphisms were examined in 81 African American and 142 Caucasian incident orolaryngeal cancer patients and 335 controls frequency-matched on age, sex, and race. In Caucasians, a significant risk increase was observed for subjects with the EH113Tyr variant (OR=2.1, 95% CI=1.1–4.0) and predicted high-activity EH genotypes in heavy-smokers (⩾35 pack-years; OR=3.4, 95% CI=1.2–9.6). A significant association between predicted high EH activity genotypes and orolaryngeal cancer risk was observed in Caucasian subjects with the GSTM1 null (OR=3.5, 95% CI=1.3–9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4–2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians.

Keywords:  Epoxide hydrolase, Glutathione S-transferase, Orolaryngeal cancer, Genetic polymorphism, Cancer susceptibility

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PII: S1368-8375(03)00008-3

doi:10.1016/S1368-8375(03)00008-3

Oral Oncology
Volume 39, Issue 5 , Pages 483-490, July 2003

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