Oral Oncology
Volume 39, Issue 5 , Pages 459-469 , July 2003

Imbalance between proliferation and apoptosis may be responsible for treatment failure after postoperative radiotherapy in squamous cell carcinoma of the oropharynx

  • Gerhard G Grabenbauer

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-9131-853-4086; fax: +49-9131-853-9335
    • ,
  • Olga Suckorada

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany
    • ,
  • Gerald Niedobitek

      Affiliations

    • Department of Pathology, University Hospital of Erlangen-Nürnberg, Germany
    • ,
  • Franz Rödel

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany
    • ,
  • Heiner Iro

      Affiliations

    • Department of Otolaryngology, Head and Neck Surgery, University Hospital of Erlangen-Nürnberg, Germany
    • ,
  • Rolf Sauer

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany
    • ,
  • Claus Rödel

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany
    • ,
  • Stefan Schultze-Mosgau

      Affiliations

    • Department of Maxillofacial Surgery of the University Hospital of Erlangen-Nürnberg, Germany
    • ,
  • Luitpold Distel

      Affiliations

    • Department of Radiation Oncology, University of Erlangen, Universitätstraße 27, 91054 Erlangen, Germany

Received 19 November 2002 ,Accepted 23 December 2002.

References 

  1. Lundahl RE, Foote RL, Bonner JA, Suman VJ, Lewis JE, Kasperbau JL. Combined neck dissection and postoperative radiation therapy in the management of the high-risk neck (a matched pair analysis). Int J Radiat Oncol Biol Phys. 1998;40:529–534
  2. Peters LJ. The efficacy of postoperative radiotherapy for advanced head and neck cancer (quality of evidence). Int J Radiat Oncol Biol Phys. 1998;40:527–528
  3. Nisi KW, Foote RL, Bonner JA, McCaffrey TV. Adjuvant radiotherapy for squamous cell carcinoma of ther tongue base (improved loco-regional disease control compared with surgery alone). Int J Radiat Oncol Biol Phys. 1998;41:371–377
  4. Bataini JP, Asselain B, Jaulerry C, Brunin F, Bernier J, Pontvert D, et al. A multivariate primary tumour control analysis in 465 patients treated by radical radiotherapy for cancer of the tonsillar region (clinical and treatment parameters as prognostic factors). Radiother Oncol. 1989;14:265–277
  5. Cox JD, Pajak TF, Marcial V, Coia L, Mohiuddin M, Fu KK. Interruptions adversly affect local control and survival with hyperfractionated radiotherapy of carcinomas of the the upper respiratory and digestive tract. Cancer. 1992;69:2744–2748
  6. Baumann M, Klages H. Comparison of various fractionation schedules in curative radiotherapy alone of locally advanced head and neck tumors. Strahlenther Onkol. 2001;177:162–165
  7. Fowler JF, Lindstrom MJ. Loss of local control with prolongation in radiotherapy. Int J Radiat Oncol Biol Phys. 1992;23:457–467
  8. Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR. An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity. Int J Radiat Oncol Biol Phys. 1997;39:137–148
  9. Akimoto T, Mitsuhashi N, Hayakawa K, Sakurai H, Murata O, Ishizeki K, et al. Split-course accelerated hyperfractionation radiotherapy for advanced head and neck cancer (influence of split time and overall treatment time on local control). Jpn J Clin Oncol. 1997;27:240–243
  10. Peters LJ, Withers HR. Applying radiobiological principles to combined modality treatment of head and neck cancer—the time factor. Int J Radiat Oncol Biol Phys. 1997;39:831–836
  11. Ang KK, Trotti A, Garden AS, Foote RL, Morrison WH. Impact of risk factors and total time for combined surgery and radiotherapy on the outcome of patients with advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 2001;51:557–578
  12. Couture C, Raybaud-Diogène H, Têtu B, Baivati I, Murry D, Allard J. Markers of radioresistance in head and neck carcinomas. Cancer. 2002;94:713–722
  13. Grabenbauer GG, Steininger H, Meyer M, Fietkau R, Brunner T, Heinkelmann P. Nodal CT density and total tumour volume as prognostic factors after radiation therapy of stage III/IV head and neck cancer. Radiother Oncol. 1998;47:175–183
  14. Sittel C, Eckel HE, Damm M, von Pritzbuer E, Kvasnicka HM. Ki-67, p53 and Lewis-X as prognostic factors of recurrence in T1 and T2 laryngeal carcinoma. Laryngoscope. 2000;110:1012–1017
  15. Welkoborski H-J, Dienes H-P, Hinni M, Mann WJ. Predicting recurrence and survival in patients with laryngeal cancer by means of DANN cytometry, tumor front grading, and proliferation markers. Ann Otol Rhinol Laryngol. 1995;104:503–510
  16. Grabenbauer GG, Mühlfriedel C, Rödel F, Niedobitek G, Hornung J, Rodel C. Squamous cell carcinoma of the oropharynx (Ki-67 and p53 can identify patients at high risk for local recurrence after sugery and postoperative radiotherapy). Int J Radiat Oncol Biol Phys. 2000;48:1041–1050
  17. Lera J, Lara PC, Rerez S, Cabreva JL, Santana C. Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma. Relations to the results of radiotherapy. Cancer. 1998;83:2493–2500
  18. Meyn RE, Stephens LC, Ang KK, Hunter NR, Brock WR, Milas L. Heterogeneity in the development of apoptosis in irradiated murine tumors of different histologies. Int J Radiat Biol. 1993;64:583–591
  19. Naresh KN, Lakshminarayanan K, Pai SA, Borges AM. Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue (a hypothesis to support this paradoxical association). Cancer. 2001;91:578–584
  20. Stoll C, Baretton G, Ahrens C, Löhrs U. Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma. Virchows Arch. 2000;4436:102–108
  21. Stevens LC, Hunter NR, Ang KK, et al.  Development of apoptosis in irradiated murine tumors as a function of time and dose. Radiat Res. 1993;135:75–80
  22. Petrasch S, Reinacher-Schick A, Busemann B, Radtke J, Philippou S, Kemmeries G. Neoadjuvant, hyperfractionated irradiation induces apoptosis and decreases proliferation in squamous cell cancer of the oral cavity. Int J Oral Maxillofac Surg. 2000;29:285–289
  23. Rödel C, Grabenbauer GG, Papadopulos T, Bigalke M, et al.  Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys. 2002;52:294–303
  24. Hermanek P, Scheibe O, Spiessl B, Wagner G. UICC—TNM-Klassifikation maligner Tumoren. 2. Auflage. Berlin: Springer Verlag; 1992;
  25. WHO. International classification of diseases for oncology. 2nd ed. Geneva: WHO; 1990.
  26. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  27. Cox DR. Regression models and life tables. J R Stat Soc B34. 1972;187–202
  28. Raouf A, Evoy D, Carton E, Mulligan E, Griffin M, Sweeney E. Spontaneous and inducible apoptosis in oesophageal adenocarcinoma. Br J Cancer. 2001;85:1781–1786
  29. Meyn RE, Stephens LC, Milas L. Programmed cell death and radioresistance. Cancer Metastases Rev. 1996;15:119–131
  30. Rödel C, Grabenbauer GG, Rödel F, Birkenhake S, Kuhn R, Martus P, et al.  Apoptosis, p53, bcl-2, and Ki-67 in invasive bladder carcinoma (possible predictors for response to radiochemotherapy and successful bladder preservation). Int J Radiat Oncol Biol Phys. 2000;46:1213–1221
  31. Ravi D, Ramadas K, Mathew BS, Panikkar KR, Nair MK, Pillai MR. Apoptosis, angiogenesis and proliferation (trifunctional measure of tumour response to radiotherapy for oral cancer). Oral Oncol. 2001;37:164–171
  32. Imoto I, Tsuda H, Hirasawa A, et al.  Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res. 2002;62:4860–4866
  33. Sheridan M, Cooper R, West CML. A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. Int J Radiat Oncol Biol Phys. 1999;44:507–512
  34. Levine EL, Renehan A, Gossiel R, et al.  Apoptosis, intrinsic radiosensitivity, and prediction of radiotherapy response in cervical carcinoma. Radiother Oncol. 1995;37:1–9
  35. Langendijk H, Thunnissen E, Arends JW, de Jong J, ten Veble G. Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy. Radiother Oncol. 2000;56:197–207
  36. Aihara M, Scardino PT, Truong LD, Wheeler TM, Goad JR, Yang G. The frequency of apoptosis correlates with the prognosis of gleason score grade 3 adenocarcinoma of the prostate. Cancer. 1995;75:522–529
  37. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe S. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature. 1996;379:88–91
  38. Rudat V, Stadler P, Becker A, Vanselow B, Dietz A, Wannenmacher M, et al. Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer. Strahlenther Onkol. 2001;177:462–468
  39. Lane DP. P53, guardian of the genome. Nature. 1992;358:15–16
  40. Sheridan MT, West CM, Cooper RA, Stratford IJ, Logue IP. Pretreatment apoptosis in carcinoma of the cervix correlates with changes in tumour oxygenation during radiotherapy. Br J Cancer. 2000;82:1177–1182

PII: S1368-8375(03)00005-8

doi: 10.1016/S1368-8375(03)00005-8

Oral Oncology
Volume 39, Issue 5 , Pages 459-469 , July 2003

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