Oral Oncology
Volume 39, Issue 3 , Pages 277-281 , April 2003

Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma

  • Fábio Ramôa Pires

      Affiliations

    • Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, n° 157, CEP: 21550-030, Rio de Janeiro/RJ, Brazil
    • ,
  • Ie-Ming Shih

      Affiliations

    • Department of Pathology, Johns Hopkins Medical Institution, Baltimore, MD, 21287, USA
    • ,
  • Danyel Elias da Cruz Perez

      Affiliations

    • Oral Pathology, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Av. Limeira, 901—CEP: 13414-903—Piracicaba/SP, Brazil
    • ,
  • Oslei Paes de Almeida

      Affiliations

    • Oral Pathology, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Av. Limeira, 901—CEP: 13414-903—Piracicaba/SP, Brazil
    • ,
  • Luiz Paulo Kowalski

      Affiliations

    • Department of Head and Neck Surgery and Otorhinolaryngology, AC Camargo Cancer Hospital, Rua Prof. Antônio Prudente, 211, Liberdade, CEP: 01509-900—São Paulo/SP, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-11-3272-5125; fax: +55-11-3277-6789

Received 20 August 2002 ,Accepted 10 October 2002.

References 

  1. Ellis GL, Auclair P. Tumors of the salivary glands. In: Atlas of tumor pathology, 3rd series, fascicle 17. Washington: Armed Forces Institute of Pathology 1996. pp 155–75, 251–7.
  2. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al.  Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25:835–845
  3. Okabe M, Inagaki H, Murase T, Inoue M, Nagai N, Eimoto T. Prognostic significance of p27 and ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland. Mod Pathol. 2001;14:1008–1014
  4. Shih I-M. The role of CD146 (Mel-CAM) in biology and pathology. J Pathol. 1999;189:4–11
  5. Shih I-M, Nesbit M, Herlyn M, Kurman RJ. A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue. Mod Pathol. 1998;11:1098–1106
  6. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res. 1987;95:229–249
  7. Wu G-J, Varma VA, Wu M-WH, Wang S-W, Qu P, Yang H, et al.  Expression of a human cell adhesion molecule, MUC18, in prostate cancer cell lines and tissues. Prostate. 2001;48:305–315
  8. Shih I-M, Wang T-L, Westra WH. Diagnostic and biological implications of Mel-CAM expression in mesenchymal neoplasms. Clin Cancer Res. 1996;2:569–575
  9. Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, et al.  Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res. 1997;57:2295–2303
  10. Shih I-M, Hsu M-Y, Palazzo JP, Herlyn M. The cell-cell adhesion receptor Mel-CAM acts as a tumor suppressor in breast carcinoma. Am J Pathol. 1997;151:745–751
  11. Shemen LJ, Huvos AG, Spiro RH. Squamous cell carcinoma of salivary gland origin. Head Neck Surg. 1987;9:235–240
  12. Auclair PL, Ellis GL. Chapter 21: primary squamous cell carcinoma. In:  Ellis GL,  Auclair PL,  Gnepp DR editor. Surgical pathology of the salivary glands. Philadelphia: W B Saunders; 1991;p. 369–379
  13. Flynn MB, Maguire S, Martinez S, Tesmer T. Primary squamous cell carcinoma of the parotid gland: the importance of correct histological diagnosis. Ann Surg Oncol. 1999;6:768–770
  14. Taxy JB. Squamous carcinoma in a major salivary gland: a review of the diagnostic considerations. Arch Pathol Lab Med. 2001;125:740–745
  15. Chu PG, Lyda MH, Weiss LM. Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. Histopathology. 2001;39:9–16
  16. de Araujo VC, de Sousa SOM, Carvalho YR, de Araujo NS. Application of immunohistochemistry to the diagnosis of salivary gland tumors. Appl Immunohistochem Mol Morphol. 2000;8:195–202
  17. Sobral AP, Loducca SV, Kowalski LP, Santos IR, Almeida OP, Araiyo NS, et al.  Immunohistochemical distinction of high-grade mucoepidermoid carcinoma and epidermoid carcinoma of the parotid region. Oral Oncol. 2002;38:437–440

PII: S1368-8375(02)00115-X

doi: 10.1016/S1368-8375(02)00115-X

Oral Oncology
Volume 39, Issue 3 , Pages 277-281 , April 2003

Article Tools

* Image Usage & Resolution