Oral Oncology
Volume 38, Issue 8 , Pages 747-751 , December 2002

Prognostic significance of microscopic and macroscopic extracapsular spread from metastatic tumor in the cervical lymph nodes

  • Alfio Ferlito

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, University of Udine, Policlinico Universitario, Piazzale S. Maria della Misericordia, I-33100 Udine, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-0432-559302; fax: +39-0432- 559339
    • ,
  • Alessandra Rinaldo

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, University of Udine, Policlinico Universitario, Piazzale S. Maria della Misericordia, I-33100 Udine, Italy
    • ,
  • Kenneth O. Devaney

      Affiliations

    • Department of Pathology, Foote Hospital, Jackson, MI, USA
    • ,
  • Ken MacLennan

      Affiliations

    • Cancer Research UK, Clinical Cancer Center, St James's University Hospital, Leeds, UK
    • ,
  • Jeffrey N. Myers

      Affiliations

    • Department of Otolaryngology, UT M.D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Guy J. Petruzzelli

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, IL, USA
    • ,
  • Ashok R. Shaha

      Affiliations

    • Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Eric M. Genden

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
    • ,
  • Jonas T. Johnson

      Affiliations

    • Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    • ,
  • Marcos B. de Carvalho

      Affiliations

    • Head and Neck Service, Heliópolis Hospital, São Paulo, Brazil
    • ,
  • Eugene N. Myers

      Affiliations

    • Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Received 14 June 2002 ,Accepted 26 June 2002.

References 

  1. Ferlito A, editor. Distant metastases from head and neck cancer: a multi-institutional view. ORL J Otorhinolaryngol Relat Spec 2001;63:187–264.
  2. León X, Ferlito A, Myer CM III, Saffiotti U, Shaha AR, Bradley PJ, Brandwein MS, Anniko M, Elluru RG, Rinaldo A. Second primary tumors in head and neck cancer patients. Acta Otolaryngol; in press.
  3. Ferlito A, Robbins KT, Shaha AR, Pellitteri PK, Kowalski LP, Gavilán J, et al. Current considerations in neck dissection. Acta Otolaryngol. 2002;122:323–329
  4. Devaney SL, Ferlito A, Rinaldo A, Devaney KO. The pathology of neck dissection in cancer of the larynx. ORL J Otorhinolaryngol Relat Spec. 2000;62:204–211
  5. Carter RL. The pathologist's appraisal of neck dissections. Eur Arch. Otorhinolaryngol. 1993;250:429–431
  6. Woolgar JA. Micrometastasis in oral/oropharyngeal squamous cell carcinoma (incidence, histopathological features and clinical implications). Br J Oral Maxillofac Surg. 1999;37:181–186
  7. Jose J, Coatesworth AP, MacLennan K. Cervical metastases in upper aerodigestive tract squamous cell carcinoma: histopathologic analysis and reporting. Head Neck 2002, in press.
  8. Buckley JG, MacLennan K. Cervical node metastases in laryngeal and hypopharyngeal cancer (a prospective analysis of prevalence and distribution). Head Neck. 2000;22:380–385
  9. Willis RA. Epidermoid carcinoma of the head and neck, with special reference to metastasis. J Pathol Bacteriol. 1930;33:501–526
  10. Bennett SH, Futrell JW, Roth JA, Hoye RC, Ketcham AS. Prognostic significance of histologic host response in cancer of the larynx or hypopharynx. Cancer. 1971;28:1255–1265
  11. Coatesworth AP, MacLennan K. Squamous cell carcinoma of the upper aerodigestive tract (the prevalence of microscopic extracapsular spread and soft tissue deposits in the clinically N0 neck). Head Neck. 2002;24:258–261
  12. Violaris NS, O'Neil D, Helliwell TR, Caslin AW, Roland NJ, Jones AS. Soft tissue cervical metastases of squamous carcinoma of the head and neck. Clin Otolaryngol. 1994;19:394–399
  13. Yousem DM, Som PM, Hackney DB, Schwaibold F, Hendrix RA. Central nodal necrosis and extracapsular neoplastic spread in cervical lymph nodes (MR imaging versus CT). Radiology. 1992;182:753–759
  14. Steinkamp HJ, Beck A, Werk M, Felix R. [Extracapsular spread of cervical lymph node metastases (Diagnostic value of magnetic resonance imaging]). Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 2002;174:50–55
  15. Genden EM, Ferlito A, Bradley PJ, Rinaldo A, Scully C. Neck disease and distant metastases. Oral Oncol; in press.
  16. Vikram B, Strong EW, Shah JP, Spiro R. Failure at distant sites following multimodality treatment for advanced head and neck cancer. Head Neck Surg. 1984;6:730–733
  17. Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB. Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer. 1993;71:452–456
  18. Nishijima W, Takooda S, Tokita N, Takayama S, Sakura M. Analyses of distant metastases in squamous cell carcinoma of the head and neck and lesions above the clavicle at autopsy. Arch Otolaryngol Head Neck Surg. 1993;119:65–68
  19. Calhoun KH, Fulmer P, Weiss R, Hokanson JA. Distant metastases from head and neck squamous cell carcinomas. Laryngoscope. 1994;104:1199–1205
  20. Carter RL, Barr LC, O'Brien CJ, Soo KC, Shaw HJ. Transcapsular spread of metastatic squamous cell carcinoma from cervical lymph nodes. Am J Surg. 1985;150:495–499
  21. Myers EN, Alvi A. Management of carcinoma of the supraglottic larynx (evolution, current concepts, and future trends). Laryngoscope. 1996;106:559–567
  22. Alvi A, Johnson JT. Development of distant metastasis after treatment of advanced-stage head and neck cancer. Head Neck. 1997;19:500–505
  23. Vaidya AM, Petruzzelli GJ, Clark J, Emami B. Patterns of spread in recurrent head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2001;125:393–396
  24. Myers JN, Greenberg JS, Mo V, Roberts D. Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer. 2001;92:3030–3036
  25. Greenberg JS, Fowler R, Gomez J, Mo V, Roberts D, El-Naggar A, Myers JN. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. J Clin Oncol; submitted for publication.
  26. Greenberg JS, El-Naggar A, Mo V, Roberts D, Myers JN. Disparity in pathologic and clinical nodal staging in oral tongue cancer: implications for therapeutic decision making. J Natl Cancer Inst; submitted for publication.
  27. de Carvalho MB. Quantitative analysis of the extent of extracapsular invasion and its prognostic significance (a prospective study of 170 cases of carcinoma of the larynx and hypopharynx). Head Neck. 1998;20:16–21
  28. Carter RL, Bliss JM, Soo KC, O'Brien CJ. Radical neck dissections for squamous carcinomas (pathological findings and their clinical implications with particular reference to transcapsular spread). Int J Radiat Oncol Biol Phys. 1987;13:825–832
  29. Alvi A, Johnson JT. Extracapsular spread in the clinically negative neck (N0) (implications and outcome). Otolaryngol Head Neck Surg. 1996;114:65–70
  30. Jose J, Coatesworth AP, Johnston C, MacLennan K. Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: the significance of extracapsular spread and soft tissue deposits. J Laryngol Otol (submitted for publication).
  31. Devineni VR, Simpson JR, Sessions D, Spector JG, Hayden R, Fredrickson J, et al. Supraglottic carcinoma: impact of radiation therapy on outcome of patients with positive margins and extracapsular nodal disease. Laryngoscope. 1991;101:767–770
  32. Johnson JT, Wagner R, Myers EN. A long-term assessment of adjuvant chemotherapy on outcome of patients with extracapsular spread of cervical metastases from squamous carcinoma of the head and neck. Cancer. 1996;77:181–185
  33. Lefebvre JL, Castelan B, De La Torre JC, Delobelle-Deroide A, Vankemel B. Lymph node invasion in hypopharynx and lateral epilarynx carcinoma (a prognostic factor). Head Neck Surg. 1987;10:14–18
  34. Hirabayashi H, Koshii K, Uno K, Ohgaki H, Nakasona Y, Fujisawa T, et al. Extracapsular spread of squamous cell carcinoma in neck lymph nodes (prognostic factor of laryngeal cancer). Laryngoscope. 1991;101:502–506
  35. Johnson JT, Barnes EL, Myers EN, Schramm VL, Borochovitz D, Sigler BA. The extracapsular spread of tumors in cervical node metastasis. Arch Otolaryngol. 1981;107:725–729
  36. Snyderman NL, Johnson JT, Schramm VL, Myers EN, Bedetti CD, Thearle P. Extracapsular spread of carcinoma in cervical lymph nodes. Impact upon survival in patients with carcinoma of the supraglottic larynx. Cancer. 1985;56:1597–1599
  37. Johnson JT, Myers EN, Bedetti CD, Barnes EL, Schramm VL, Thearle P. Cervical lymph node metastases. Incidence and implications of extracapsular carcinoma. Arch Otolaryngol. 1985;111:534–537
  38. Stell PM. Prognosis in laryngeal carcinoma (tumour factors). Clin Otolaryngol. 1990;15:69–81
  39. Snow GB, Annyas AA, van Slooten EA, Bartelink H, Hart AA. Prognostic factors of neck nodal metastasis. Clin Otolaryngol. 1982;7:185–192
  40. de Guzman RB, Martorell MA, Basterra J, Armengot M, Alvarez-Valdes R, Garin L. Prognostic value of histopathologic parameters in 51 supraglottic squamous cell carcinomas. Laryngoscope. 1993;103:538–540
  41. Del Valle-Zapico A, Fernandez FF, Suarez AR, Angulo CM, Quintela JR. Prognostic value of histopathologic parameters and DNA flow cytometry in squamous cell carcinoma of the pyriform sinus. Laryngoscope. 1998;108:269–272
  42. Morales-Angulo C, Val-Bernal F, Buelta L, Fernandez F, Garcia-Castrillo L, Rama J. Prognostic factors in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg. 1998;119:548–553
  43. Bilgen C, Sarioglu S, Ceryan K. Evaluation of the primary tumour and the metastatic lymph node with or without extracapsular spread by means of argyrophillic nucleolar regions (AgNOR). Rev Laryngol Otol Rhinol (Bord). 2000;121:155–159
  44. Mamelle G, Pampurik J, Lubionski B, Lancar R, Lusinshi A, Bosq J. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994;168:494–498
  45. Pinsolle J, Pinsolle V, Majoufre C, Durous S, Demeaux H, Siberchicot F. Prognostic value of histologic findings in neck dissections for squamous carcinoma. Arch Otolaryngol Head Neck Surg. 1997;123:145–148
  46. Gallo O, Boddi V, Bottai GV, Franchi A, Storchi OF. Prognostic significance of clinically false positive cervical lymph nodes in patients with laryngeal carcinoma. Cancer. 1995;75:1077–1083
  47. Alderson DJ, Jones TM, White SJ, Roland NJ. Observer error in the assessment of nodal disease in head and neck cancer. Head Neck. 2001;23:739–743
  48. Ferlito A, Buckley JG, Shaha AR, Rinaldo A. Rationale for selective neck dissection in tumors of the upper aerodigestive tract. Acta Otolaryngol. 2001;121:548–555

PII: S1368-8375(02)00052-0

doi: 10.1016/S1368-8375(02)00052-0

Oral Oncology
Volume 38, Issue 8 , Pages 747-751 , December 2002

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