Oral Oncology
Volume 38, Issue 8 , Pages 793-796, December 2002

Intra-osseous soft tissue perineurioma of the inferior alveolar nerve

  • A.W Barrett

      Affiliations

    • Oral and Maxillofacial Pathology Unit, Eastman Dental Institute for Oral Healthcare Sciences, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
    • Department of Histopathology, Royal Free and University College Medical School, Rockefeller Building, University Street, London WC1E 6JJ, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-20-7915-1055; fax: +44-20-7915-1213
    • ,
  • C Hopper

      Affiliations

    • Maxillofacial Surgery Unit, Eastman Dental Institute for Oral Healthcare Scinces, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
    • ,
  • G Landon

      Affiliations

    • Department of Histopathology, Royal Free and University College Medical School, Rockefeller Building, University Street, London WC1E 6JJ, UK

Received 14 January 2002; accepted 21 January 2002.

Abstract 

This report describes an intra-osseous perineurioma affecting the inferior alveolar nerve, the second at this site, of a 53-year-old man. It produced a well defined, partially corticated, round radiolucency associated with resorption of the root apices of 36 and 37. Histology showed a circumscribed, partially encapsulated cellular tumour composed of bland spindle cells with undulating nuclei and indistinct cell membranes arranged in interlacing fascicles. The tumour was strongly positive for epithelial membrane antigen, collagen IV and laminin, with only scattered S100-positive cells and lack of CD34 expression. Electron microscopy showed elongated cells with continuous external laminae of basement membrane-like material, subplasmalemmal densities, desmosome-like junctions, and variable numbers of micropinocytotic vesicles. The lesion was surgically excised and in 9 months there has been no recurrence.

Keywords:  Perineurioma, Nerve sheath tumour, EMA, Immunohistochemistry, Electron microscopy

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PII: S1368-8375(02)00005-2

doi:10.1016/S1368-8375(02)00005-2

Oral Oncology
Volume 38, Issue 8 , Pages 793-796, December 2002

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