Oral Oncology
Volume 38, Issue 6 , Pages 543-548 , September 2002

Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy

  • G Matsumoto

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-468-22-8895; fax: +81-468-22-8801
    • ,
  • K Sasakuri

      Affiliations

    • Department of Orthodontics, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan
    • ,
  • K Tsukinoki

      Affiliations

    • Department of Oral Pathology, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan
    • ,
  • Y Ohmi

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan
    • ,
  • U Lee

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan
    • ,
  • J Shindo

      Affiliations

    • First Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka, Yokosuka, Kanagawa, 238-8580 Japan

Received 18 October 2001 ,Accepted 4 November 2001.

References 

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  2. Matsumoto G, Ohmi Y, Shindo J. Angiostatin gene therapy inhibits the growth of murine squamous cell carcinoma in vivo. Oral Oncology. 2001;37:369–378
  3. Nguyen JT, Wu P, Clouse ME, Hlatky L, Terwilliger EF. Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy. Cancer Research. 1998;58:5673–5677
  4. Tanaka T, Cao Y, Folkman J, Fine HA. Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA. Cancer Research. 1998;58:3362–3369
  5. Griscelli F, Li H, Cheong C, Opolon P, Bennaceur-Griscelli A, Vassal G, et al. Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model. Proceedings of the National Academy of Sciences of the United States of America. 2000;97:6698–6703
  6. Cao Y, O'Reilly MS, Marshall B, Flynn E, Ji R-W, Folkman J. Expression of angiostatin cDNA in murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases. Journal of Clinical Investigation. 1998;101:1055–1063
  7. Benjamin LE, Golojanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. Journal of Clinical Investigation. 1999;103:159–165
  8. Blezinger P, Wang J, Gondo M, Quezada A, Mehrens D, French M, et al. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nature Biotechnology. 1999;17:343–348
  9. Sacco MG, Caniatti M, Cato EM, Frattini A, Chiesa G, Ceruti R, et al. Liposome-derived angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer. Cancer Research. 2000;60:2660–2665
  10. Krisch M, Strasser J, Allende R, Bello L, Zhang J, Black PM. Angiostatin suppresses malignant glioma growth in vivo. Cancer Research. 1998;58:4654–4659
  11. Jennifer JW, David CS. Angiostatin binds to smooth muscle cells in the coronary artery and inhibits smooth muscle cells proliferation and migration in vitro. Arterioscler Thromb Vasc Biology. 1999;19:2041–2048

PII: S1368-8375(01)00126-9

Oral Oncology
Volume 38, Issue 6 , Pages 543-548 , September 2002

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