Oral Oncology
Volume 38, Issue 4 , Pages 357-363 , June 2002

Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features

  • Juan P Rodrigo

      Affiliations

    • Department of Otolaryngology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34-985-108000, ext. 38140; fax: +34-985-108015
    • ,
  • Maria V González

      Affiliations

    • Department of Otolaryngology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Pedro S Lazo

      Affiliations

    • Department of Biochemistry and Molecular Biology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Sofı́a Ramos

      Affiliations

    • Department of Biochemistry and Molecular Biology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Eliecer Coto

      Affiliations

    • Department of Molecular Genetics, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Ignacio Alvarez

      Affiliations

    • Department of Otolaryngology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Luis A Garcı́a

      Affiliations

    • Department of Otolaryngology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain
    • ,
  • Carlos Suárez

      Affiliations

    • Department of Otolaryngology, Hospital Central de Asturias, University of Oviedo, Instituto Universitario de Oncologı́a, Oviedo, Spain

Received 2 May 2001 ,Accepted 7 June 2001.

References 

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  3. Rodrigo JP, Ramos S, Lazo PS, Alvarez I, Suárez C. Amplification of ERBB oncogenes in squamous cell carcinomas of the head and neck. Eur. J. Cancer. 1996;32A(11):2004–2010
  4. Rodrigo JP, Garcia LA, Ramos S, Lazo PS, Suárez C. EMS1 amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin. Cancer Res. 2000;6(8):3177–3182
  5. Gonzalez MV, Pello MF, López-Larrea C, Suárez C, Menendez MJ, Coto E. Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17p13) genes in squamous cell carcinoma of the head and neck. Clin. Cancer Res. 1995;1(9):1043–1049
  6. Alvarez I, Lazo PS, Ramos S, Rodrigo JP, Nuñez F, Suárez C. Using polymerase chain reaction to Human Papillomavirus in oral and pharyngolaryngeal carcinomas. Am. J. Otolaryngol. 1997;18(6):375–381
  7. Alavi S, Namazie A, Calcaterra TC, Wang MB, Srivatsan ES. Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis in head and neck cancer. Laryngoscope. 1999;109(6):874–879
  8. Meredith SD, Levine PA, Burns JA, Gaffey MJ, Boyd JC, Weiss LM, et al.  Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis. Arch. Otolaryngol. Head Neck Surg. 1995;121(7):790–794
  9. Muller D, Millon R, Velten M, Bronner G, Jung G, Engelmann A, et al.  Amplification of 11q13 DNA markers in head and neck squamous cell carcinomas: correlation with clinical outcome. Eur. J. Cancer. 1997;33A(13):2203–2210
  10. Leonard JH, Kearsley JH, Chenevix-Trench G, Hayward NK. Analysis of gene amplification in head and neck squamous cell carcinoma. Int. J. Cancer. 1991;48(4):511–515
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  14. Gleich LL, Li YQ, Biddinger PW, Gartside PS, Stambrook PJ, Pavelic ZP, et al.  The loss of heterozygosity in retinoblastoma and p53 suppressor genes as a prognostic indicator for head and neck cancer. Laryngoscope. 1996;106(11):1378–1381
  15. Gleich LL, Li YQ, Wang X, Stambrook PJ, Gluckman JL. Variable genetic alterations and survival in head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 1999;125(9):949–952
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  17. Scholnick SB, Haughey BH, Sunwoo JB, el-Mofty SK, Baty JD, Piccirillo JF, et al.  Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx. J. Natl. Cancer Inst. 1996;88(22):1676–1682
  18. Gonzalez MV, Alvarez V, Pello MF, Menéndez MJ, Suárez C, Coto E. Genetic polymorphism of N-acetyltransferase-2, glutatione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer. J. Clin. Pathol. 1998;51(4):294–298
  19. Niedobitek G, Pitteroff S, Herbst H, Shepherd P, Finn T, Anagnostopoulos I, et al.  Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. J. Clin. Pathol. 1990;43(11):918–921
  20. Ishibashi T, Matsushima S, Tsunokawa Y, Asai M, Nomura Y, Sugimura T, et al.  Human papillomavirus DNA in squamous cell carcinoma of the upper aerodigestive tract. Arch. Otolaryngol. Head Neck Surg. 1990;116(3):294–298

PII: S1368-8375(01)00071-9

Oral Oncology
Volume 38, Issue 4 , Pages 357-363 , June 2002

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