Oral Oncology
Volume 38, Issue 3 , Pages 301-308 , April 2002

Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance

  • Juan Carlos de Vicente

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain
    • Corresponding Author InformationCorresponding author. Escuela de Estomatologı́a, C/ Catedrático José Serrano s/n, 33006, Oviedo, Spain. Tel.: +34-85-103638; fax: +34-85-103673
  • ,
  • Agustı́n Herrero-Zapatero

      Affiliations

    • Department of Pathology, University Hospital of Oviedo, Oviedo, Spain
  • ,
  • Manuel Florentino Fresno

      Affiliations

    • Department of Pathology, University Hospital of Oviedo, Oviedo, Spain
  • ,
  • Juan Sebastián López-Arranz

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain

Received 9 April 2001 ,Revised 22 April 2001 ,Accepted 1 June 2001.

References 

  1. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med. 1993;328(3):184–194
  2. Lingen MW, Chang K-W, McMurray SJ, Solt DB, Kies MS, Mittal BB, et al.  Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5-9. Head Neck. 2000;22(4):328–335
  3. Shah JP, Lydiatt W. Treatment of cancer of the head and neck. CA Cancer J Clin. 1995;45(6):352–368
  4. Tralongo V, Rodolico V, Luciani A, Marra G, Daniele E. Prognostic factors in oral squamous cell carcinoma. A review of the literature. Anticancer Res. 1999;19(4C):3503–3510
  5. Salesiotis AN, Cullen KJ. Molecular markers predictive of response and prognosis in the patient with advanced squamous cell carcinoma of the head and neck: evolution of a model beyond TNM staging. Curr Opin Oncol. 2000;12(3):229–239
  6. Williams HK. Molecular pathogenesis of oral squamous carcinoma. J Clin Pathol: Mol Pathol. 2000;53(4):165–172
  7. Michalides RJAM. Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer. J Clin Pathol. 1999;52:555–568
  8. Marshall C. Tumor supressor genes. Cell. 1991;64(2):313–326
  9. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81(3):323–330
  10. Hall M, Peters G. Genetic alterations of cyclins, cyclin-dependent kinases and cdk inhibitors in human cancer. Adv Cancer Res. 1996;68:67–108
  11. Sherr CJ. Cancer cell cycles. Science. 1996;274(5293):1672–1677
  12. Kudo Y, Takata T, Ogawa I, Kaneda T, Sato S, Takekoshi T, et al.  p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin Cancer Res. 2000;6(3):916–923
  13. Kuo MY, Lin CY, Hahn LJ, Cheng SJ, Chiang CP. Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. J Oral Pathol Med. 1999;28(4):165–169
  14. Motokura T, Arnold A. Cyclins and oncogenesis. Biochim Biophy Acta. 1993;1155(1):63–78
  15. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathology. 1990;17(6):489–503
  16. van Diest PJ, Brugal G, Baak JPA. Proliferation markers in tumours: interpretation and clinical value. J Clin Pathol. 1998;51:716–724
  17. Bruno S, Dazynkiewicz Z. Cell cycle dependent expression and stability of the nuclear antigen detected by Ki67 antibody in HL-60 cells. Cell Prolif. 1992;25(1):31–40
  18. Li T-J, Browne RM, Matthews JB. Epithelial cell proliferation in odontogenic keratocysts: a comparative immunocytochemical study of Ki67 in simple, recurrent and basal cell naevus syndrome (BCNS)-associated lesions. J Oral Pathol Med. 1995;24(5):221–226
  19. In:  Sobin LH,  Witterkind Ch editor. TNM classification of malignant tumors. New York: Wiley-Liss; 1997;
  20. Mineta H, Miura K, Takebayashi S, Ueda Y, Misawa K, Harada H, et al.  Cyclin D1 overexpression correlates with poor prognosis in patients with tongue squamous cell carcinoma. Oral Oncology. 2000;36(2):194–198
  21. Masuda M, Hirakawa N, Nakashima T, Kuratomi Y, Komiyama S. Cyclin D1 overexpression in primary hypopharyngeal carcinomas. Cancer. 1996;78(3):390–395
  22. Callender T, El-Naggar AK, Lee MS, Frankenthaler R, Luna MA, Batsakis JG. PRAD-1 (CCND1)/cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer. 1994;74(1):152–158
  23. Lam KY, Ng IOL, Yuen APW, Kwong DLW, Wei W. Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression. J Oral Pathol Med. 2000;29(4):167–172
  24. Gimenez-Conti IB, Collet AM, Lanfranchi H, Itoiz ME, Luna M, Xu HJ, et al.  p53, Rb, and cyclin D1 expression in human oral verrucous carcinomas. Cancer. 1996;78(1):17–23
  25. Guillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, et al.  Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res. 1994;54(7):1812–1817
  26. Nikaido T, Li S, Shiozawa T, Fuji S. Coabnormal expression of cyclin D1 and p53 protein in human uterine endometrial carcinomas. Cancer. 1996;78(6):1248–1253
  27. Akervall JA, Michalides RJ, Mineta H, Balm A, Borg A, Dictor MR, et al.  Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer. 1997;79(2):380–389
  28. Xu J, Gimenez-Conti IB, Cunningham JE, Collet AM, Luna MA, Lanfranchi HE, et al.  Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use. Cancer. 1998;83(2):204–212
  29. Capaccio P, Pruneri G, Carboni N, Pagliari AV, Quatela M, Cesana BM, et al.  Cyclin D1 expression is predictive of occult metastases in head and neck cancer patients with clinically negative cervical lymph nodes. Head Neck. 2000;22(3):234–240
  30. Fortin A, Guerry M, Guerry R, Talbot M, Parise O, Schwaab G, et al.  Chromosome 11q13 gene amplifications in oral and oropharyngeal carcinomas: no correlation with subclinical lymph node invasion and disease recurrence. Clin Can Res. 1997;3(9):1609–1614
  31. Bova RJ, Quinn DI, Nankervis JS, Cole IE, Sheridan BF, Jensen MJ, et al.  Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. Clin Cancer Res. 1999;5(10):2810–2819
  32. Franchi A, Gallo O, Boddi V, Santucci M. Prediction of occult neck metastases in laryngeal carcinoma: role of proliferating cell nuclear antigen, MIB-1, and E-cadherin immunohistochemical determination. Clin Cancer Res. 1996;2(10):1801–1808
  33. Roychowdhury DF, Tseng A, Fu KK, Weinburg V, Weidner N. New prognostic factors in nasopharyngeal carcinoma. Tumor angiogenesis and C-erbB2 expression. Cancer. 1996;77(8):1419–1426
  34. Stoll C, Baretton G, Ahrens C, Löhrs U. Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma. Virchows Arch. 2000;436(2):102–108
  35. Yamanaka N, Harabuchi Y, Kataura A. The prognostic value of Ki-67 antigen in non-Hodgkin lymphoma of Waldeyer ring and the nasal cavity. Cancer. 1992;70(9):2342–2349

PII: S1368-8375(01)00060-4

Oral Oncology
Volume 38, Issue 3 , Pages 301-308 , April 2002