Oral Oncology
Volume 38, Issue 3 , Pages 301-308, April 2002

Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance

  • Juan Carlos de Vicente

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain
    • Corresponding Author InformationCorresponding author. Escuela de Estomatologı́a, C/ Catedrático José Serrano s/n, 33006, Oviedo, Spain. Tel.: +34-85-103638; fax: +34-85-103673
    • ,
  • Agustı́n Herrero-Zapatero

      Affiliations

    • Department of Pathology, University Hospital of Oviedo, Oviedo, Spain
    • ,
  • Manuel Florentino Fresno

      Affiliations

    • Department of Pathology, University Hospital of Oviedo, Oviedo, Spain
    • ,
  • Juan Sebastián López-Arranz

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain

Received 9 April 2001; received in revised form 22 April 2001; accepted 1 June 2001.

Abstract 

The prognostic and clinicopathologic significance of cyclin D1 and Ki-67 expressions was studied in oral squamous cell carcinomas. We performed an immunohistochemical study to determine the level of expression of cyclin D1 and Ki-67 labelling index in tumor specimens obtained from 35 patients, of whom 14 died as a result of recurrent disease, and 20 were free of recurrence at the end of the follow-up period. Overexpression of cyclin D1 was significantly associated with regional lymph node metastases (P=0.00005) and advanced tumor stage (P=0.0007). The relative risk for nodal metastases in the cases that overexpressed cyclin D1 was 2.6. The Ki-67 labelling index was significantly (P=0.001) higher in tumors with poor histologic grade of differentiation. Our results showed that cyclin D1 is a useful prognostic factor, and suggested it could be a marker to help determine the appropiate treatment for patients with oral squamous cell carcinoma. Cyclin D1 and Ki-67 overexpression were positively correlated.

Keywords:  Cyclin D1, Ki67, Immunohistochemistry, Oral, Squamous cell carcinoma, Prognosis

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PII: S1368-8375(01)00060-4

Oral Oncology
Volume 38, Issue 3 , Pages 301-308, April 2002

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