Oral Oncology
Volume 38, Issue 3 , Pages 296-300 , April 2002

P53 tumor suppressor gene mutations in laryngeal cancer and in recurrent disease following radiation therapy

  • G.W.A Tjebbes

      Affiliations

    • Department of Otorhinolaryngology (G05.101), University Hospital Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31-30-2506645; fax: +31-30-2541922
    • ,
  • P.A Kreijveld

      Affiliations

    • Department of Pathology, University Hospital Utrecht, Utrecht, The Netherlands
    • ,
  • M.G.J Tilanus

      Affiliations

    • Department of Pathology, University Hospital Utrecht, Utrecht, The Netherlands
    • ,
  • G.J Hordijk

      Affiliations

    • Department of Otorhinolaryngology (G05.101), University Hospital Utrecht, PO box 85500, 3508 GA Utrecht, The Netherlands
    • ,
  • P.J Slootweg

      Affiliations

    • Department of Pathology, University Hospital Utrecht, Utrecht, The Netherlands

Received 18 March 2001 ,Revised 26 March 2001 ,Accepted 1 June 2001.

References 

  1. Kropveld A, Rozemuller EH, Leppers FGJ, Scheidel KC, de Weger RA, Koole R, et al.  Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers. Lab Invest. 1999;79(3):347–353
  2. Tjebbes GWA, Leppers vd Straat FGJ, Tilanus MGJ, Hordijk GJ, Slootweg PJ. P53 tumor suppressor gene as a clonal marker in head and neck squamous cell carcinoma (p53 mutations in primary tumor and matched lymph node metastases). Eur J Cancer B Oral Oncol. 1999;35:384–389
  3. Van Oijen MG, Leppers vd Straat FGJ, Tilanus MGJ, Slootweg PJ. The origins of multiple squamous cell carcinomas in the aerodigestive tract. Cancer. 2000;88(4):884–893
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PII: S1368-8375(01)00059-8

Oral Oncology
Volume 38, Issue 3 , Pages 296-300 , April 2002

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