Oral Oncology
Volume 38, Issue 3 , Pages 281-290 , April 2002

Acetaldehyde activates Jun/AP-1 expression and DNA binding activity in human oral keratinocytes

  • Sherry R Timmons

      Affiliations

    • Oral Sciences Graduate Program, B180ML, The University of Iowa, Iowa City, IA 52242, USA
  • ,
  • Joseph O Nwankwo

      Affiliations

    • Department of Biochemistry, B180ML, The University of Iowa, Iowa City, IA 52242, USA
  • ,
  • Frederick E Domann

      Affiliations

    • Free Radical and Radiation Biology Graduate Program and Holden Comprehensive Cancer Center, B180ML, The University of Iowa, Iowa City, IA 52242, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-335-8018; fax: +1-319-335-8039

Received 9 April 2001 ,Accepted 22 April 2001.

References 

  1. Riveros-Rosas H, Julian-Sanchez A, Pina E. Enzymology of ethanol and acetaldehyde metabolism in mammals. Archives of Medical Research. 1997;28(4):453–471
  2. Squier CA, Cox P, Hall BK. Enhanced penetration of nitrosonornicotine across oral mucosa in the presence of ethanol. Journal of Oral Pathology. 1986;15(5):276–279
  3. Bakker BM, Bro C, Kotter P, Luttik MA, van Dijken DP, Pronk JT. The mitochondrial alcohol dehydrogenase Adh3p is involved in a redox shuttle in Saccharomyces cerevisiae. Journal of Bacteriology. 2000;182(17):4730–4737
  4. Borras E, Coutelle C, Rosell A, Fernandez-Muixi F, Broch M, Crosas B. Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology. 2000;31(4):984–989
  5. Bosron WF, Lumeng L, Li TK. Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molecular Aspects of Medicine. 1988;10(2):147–158
  6. Bouchardy C, Hirvonen A, Coutell C, Ward PJ, Dayer P, Benhamou S. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. International Journal of Cancer. 2000;87(5):734–740
  7. Coutelle C, Ward PJ, Fleury B, Quattrocchi P, Chambrin H, Iron A, et al. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms. Human Genetics. 1997;99(3):319–325
  8. Kunitoh S, Imaoka S, Hiroi T, Yabusaki Y, Monna T, Funae Y. Acetaldehyde as well as ethanol is metabolized by human CYP2E1. Journal of Pharmacology and Experimental Therapeutics. 1997;280(2):527–532
  9. Dong YJ, Peng TK, Yin SJ. Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth. Alcohol. 1996;13(3):257–262
  10. Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis. 1997;18(9):1739–1743
  11. Homann N, Tillonen J, Meurman JH, Rintamaki H, Lindqvist C, Rautio M, et al. Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis. 2000;21(4):663–668
  12. Jokelainen K, Heikkonen E, Roine R, Lehtonen H, Salaspuro M. Increased acetaldehyde production by mouthwashings from patients with oral cavity, laryngeal, or pharyngeal cancer. Alcoholism: Clinical and Experimental Research. 1996;20(7):1206–1210
  13. Jones AW. Measuring and reporting the concentration of acetaldehyde in human breath. Alcohol and Alcoholism. 1995;30(3):271–285
  14. Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blot WJ, et al.  Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers [see comments]. Journal of the National Cancer Institute. 1997;89(22):1698–1705
  15. Tillonen J, Homann N, Rautio M, Jousimies-Somer H, Salaspuro M. Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. Alcoholism: Clinical and Experimental Research. 1999;23(8):1409–1415
  16. Dellarco VL. A mutagenicity assessment of acetaldehyde. Mutation Research. 1988;195(1):1–20
  17. Feron VJ, Kruysse A, Woutersen RA. Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. European Journal of Cancer & Clinical Oncology. 1982;18(1):13–31
  18. Helander A, Lindahl-Kiessling K. Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor. Mutation Research. 1991;264(3):103–107
  19. Nakamura K, Iwahashi K, Itoh M, Ameno K, Ijiri I, Takeuchi Y, et al. Immunohistochemical study on acetaldehyde adducts in alcohol-fed mice. Alcoholism: Clinical and Experimental Research. 2000;24(4 Suppl):93S–96S
  20. Ristow H, Seyfarth A, Lochmann ER. Chromosomal damages by ethanol and acetaldehyde in Saccharomyces cerevisiae as studied by pulsed field gel electrophoresis. Mutation Research. 1995;326(2):165–170
  21. Homann N, Tillonen J, Rintamaki H, Salaspuro M, Lindquist C, Meurman JH. Poor dental status increase acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral Oncology. 2001;37:153–158
  22. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987;49(6):729–739
  23. Domann FE, Levy JP, Finch JS, Bowden GT. Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells. Molecular Carcinogenesis. 1994;9(2):61–66
  24. Domann FE, Levy JP, Birrer MJ, Bowden GT. Stable expression of a c-Jun deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth and Differentiation. 1994;5(1):9–16
  25. Riva C, Lavieille JP, Reyt E, Brambilla E, Lunardi J, Brambilla C. Differential c-myc, c-jun, c-raf and p53 expression in squamous cell carcinoma of the head and neck: implication in drug and radioresistance. European Journal of Cancer. Part B, Oral Oncology. 1995;31B(6):384–391
  26. Kharbanda S, Nakamura T, Kufe D. Induction of the c-jun proto-oncogene by a protein kinase C-dependent mechanism during exposure of human epidermal keratinocytes to ethanol. Biochemical Pharmacology. 1993;45(3):675–681
  27. Kim SJ, Lafyatis R, Kim KY, Angel P, Fujiki H, Karin M, et al. Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regulation. 1990;1(3):269–278
  28. Spandidos DA. Mechanism of carcinogenesis: the role of oncogenes, transcriptional enhancers and growth factors. Anticancer Research. 1985;5(5):485–498
  29. Young MR, Li JJ, Rincon M, Flavell RA, Sathyanarayana BK, Hunziker R, et al. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proceedings of the National Academy of Sciences of the United States of America. 1996;96(17):9827–9832
  30. Zhou H, Lin A, Gu Z, Chen S, Park NH, Chiu R. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. Journal of Biological Chemistry. 2000;275(30):22868–22875
  31. Peng J, Bowden GT, Domann FE. Activation of AP-1 by okadaic acid in mouse keratinocytes associated with hyperphosphorylation of c-jun. Molecular Carcinogenesis. 1997;18(1):37–43
  32. Li SL, Kim MS, Cherrick HM, Doniger J, Park NH. Sequential combined tumorigenic effect of HPV-16 and chemical carcinogens. Carcinogenesis. 1992;13(11):1981–1987
  33. Kim MS, Shin KH, Baek JH, Cherrick HM, Park NH. HPV-16, tobacco-specific N-nitrosamine, and N-methyl-N′-nitro-N-nitrosoguanidine in oral carcinogenesis. Cancer Research. 1993;53(20):4811–4816
  34. Park NH, Gujuluva CN, Baek JH, Cherrick HM, Shin KH, Min BM. Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model. Oncogene. 1995;10(11):2145–2153
  35. Cederbaum AI, Wu D. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. Journal of Biological Chemistry. 1996;271(39):23914–23919
  36. Roman J, Gimenez A, Lluis JM, Gasso M, Rubio M, Caballeria J, et al. Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells. Journal of Biological Chemistry. 2000;275(19):14684–14690
  37. Casini A, Ceni E, Salzano R, Milani S, Schuppan D, Surrenti C. Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and-2 in human fat-storing cells. Life Sciences. 1994;55(17):1311–1316
  38. Angel P, Karin M. Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli. Matrix Supplement. 1992;1:156–164
  39. Muller D, Wolf C, Abecassis J, Millon X, Engelmann A, Bronner G, et al. Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. Cancer Research. 1993;53(1):165–169

PII: S1368-8375(01)00056-2

Oral Oncology
Volume 38, Issue 3 , Pages 281-290 , April 2002