Oral Oncology
Volume 38, Issue 3 , Pages 274-280 , April 2002

Apoptosis, proliferation and p12doc-1 profiles in normal, dysplastic and malignant squamous epithelium of the Syrian hamster cheek pouch model

  • Yohko Kohno

      Affiliations

    • Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    • ,
  • Vipul Patel

      Affiliations

    • Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    • ,
  • Yong Kim

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, 1 Fruit Street, Boston, MA 02114, USA
    • ,
  • Takanori Tsuji

      Affiliations

    • Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    • ,
  • Byung-Rho Chin

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, 1 Fruit Street, Boston, MA 02114, USA
    • ,
  • Moyi Sun

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, 1 Fruit Street, Boston, MA 02114, USA
    • ,
  • R Bruce Donoff

      Affiliations

    • Dean, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    • ,
  • Ralph Kent

      Affiliations

    • Forsyth Institute, Boston, MA 02115, USA
    • ,
  • David Wong

      Affiliations

    • Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    • ,
  • Randy Todd

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, 1 Fruit Street, Boston, MA 02114, USA
    • Corresponding Author InformationCorresponding author. Present address. Department of Oral & Maxillofacial Surgery, Harvard School of Dental Medicine/Massachusetts General Hospital, 188 Longwood Avenue, Boston, MA 02115, USA. Fax: +1-617-432-2449

Received 25 April 2001 ,Accepted 18 May 2001.

References 

  1. Polverini PJ, Nor JE. Apoptosis and predisposition to oral cancer. Critical Reviews in Oral Biology and Medicine. 1999;10:139–152
  2. Birchall MA, Winterford CM, Allan DJ, Harmon BV. Apoptosis in normal epithelium, premalignant and malignant lesions of the oropharynx and oral cavity: a preliminary study. Oral Oncology, European Journal of Cancer. 1995;31B:380–383
  3. Ravi D, Ramadas K, Mathew BS, Nalinakumari KR, Nair MK, Pillai MR. De novo programmed cell death in oral cancer. Histopathology. 1999;34:241–249
  4. Birchall M, Winterford C, Tripconi L, Gobe G, Harmon B. Apoptosis and mitosis in oral and oropharyngeal epithelia (evidence for a topographical switch in premalignant lesions). Cell Proliferation. 1996;29:447–456
  5. Kotelnikov VM, Coon JS, Mundle S, Kelanic S, LaFollette S, Taylor S, et al.  Cyclin D1 expression in squamous cell carcinomas of the head and neck and in oral mucosa in relation ot proliferation and apoptosis. Clinical Cancer Research. 1997;3:95–101
  6. Xie X, Clausen OPF, DeAngelis P, Boysen M. The prognostic value of spontaneous apoptosis, bax, bcl-2, and p3 in oral squamous cell carcinomaof the tongue. Cancer. 1999;86:913–920
  7. Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. bcl-1 but not bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clinical Cancer Research. 1998;4:2913–2921
  8. Schoelch ML, Le QT, Silverman S, McMillan A, Dekker NP, Fu KK, et al.  Apoptosis-associated proteins and the development of oral squamous cell carcinoma. Oral Oncology. 1999;35:77–85
  9. Clayman GL, Frank DK, Bruso PA, Goepfert H. Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers. Clinical Cancer Research. 1999;5:1715–1722
  10. Lui T-J, Wang M, Breau RL, Henderson Y, El-Naggar AK, Steck KD, et al.  Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines. Cancer Gene Therapy. 1999;6:163–171
  11. Salley JJ. Histologic changes in the hamster cheek pouch during early hydrocarbon carcinogenesis. Journal of Dental Research. 1957;36:48–55
  12. Shklar G, Turbiner S, Siegel W. Chemical carcinogenesis of hamster mucosa, reaction to dimethyl sulfoxide. Archives of Pathology. 1969;87:637–642
  13. Shklar G. Experimental oral pathology in the Syrian hamster. Progress in Experimental Tumor Research. 1972;16:518–538
  14. Gimenez-Conti IB, Slaga TJ. The hamster cheek pouch carcinogenesis model. Journal of Cellular Biochemistry Supplement. 1993;17F:83–90
  15. Shklar G. Development of experimental oral carcinogenesis and its impact on oral cancer research. Journal of Dental Research. 1999;78:1768–1772
  16. Cwikla SJ, Tsuji T, McBride J, Wong DTW, Todd R. doc-1 mediated apoptosis in malignant hamster oral keratinocytes. Journal of Oral Maxillofacial Surgery. 2000;58:406–414
  17. Todd R, McBride J, Tsuji T, Donoff RB, Nagai M, Chou MY, et al.  Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene. FASEB Journal. 1995;9:1362–1370
  18. Tsuji T, Duh R-M, Latif FL, Popescu NC, Zimonjic DB, McBride J, et al.  Cloning, mapping expression, function and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene doc-1. Journal of Biological Chemistry. 1998;273:6704–6709
  19. Shintani S, Mihara M, Terakado N, Nakahara Y, Matsumura,T, Kohno Y, et al. Reduction of p12DOC-1 expression is a negative prognostic indicator in head and neck/oral cancer. Clinical Cancer Research 2001 (in press).
  20. Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, et al.  p12DOC-1 is a novel CDK2-associated protein. Molecular Cellular Biology. 2001;20:6300–6307
  21. Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, et al.  p12DOC-1, a growth suppressor, associates with DNA polymerase α/primase. FASEB Journal. 2000;14:1318–1324
  22. Chang LC, Chou MY, Chow P, Matossian K, McBride J, Chiang T, et al.  Detection of transforming growth factor-alpha messenger RNA in normal and chemically transformed hamster oral epithelium by in situ hybridization. Cancer Research. 1989;49:6700–6707
  23. Todd R, Hinds P, Munger K, Rustgi AK, Opitz OG, Suliman Y, et al. Cell cycle dysregulation in oral cancer. Critical Reviews in Oral Biology and Medicine 2001 (in press).
  24. Li N, Han C, Chen J. Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. Nutrition and Cancer. 1999;35:73–79
  25. Sumida T, Hamakawa H, Sogawa K, Bao Y, Zen H, Sugita A, et al.  Telomerase activation and cell proliferation during 7,12-dimethylbenz[a]antracene-induced hamster cheek pouch carcinogenesis. Molecular Carcinogenesis. 1999;25:164–168
  26. Ohnishi M, Yoshimi N, Kawamori T, Ino N, Hirose Y, Tanaka T, et al.  Inhibitory effects of dietary protocatechuic acid and costunolide on 7,12-dimethylbenz[a]antracene-induced hamster cheek pouch carcinogenesis. Japanese Journal of Cancer Research. 1997;88:111–119
  27. Wong DTW, Chou MY, Chang LC, Gallagher GT. Use of intracellular H3 messenger RNA as a marker to determine the proliferation pattern of normal and 7,12-dimethylbenz[a]anthracene-transformed hamster oral epithelium. Cancer Research. 1990;50:5107–5111
  28. Kaku T, Ohuchi T, Nakade O, Ogawa A, Kanno H, Abe H, et al.  Patterns of epithelial proliferation revealed by intraperitoneal administration of bromodeoxyuridine during buccal pouch carcinogenesis in hamsters. Shika Kiso Igakkai Zasshi. 1989;31:749–752
  29. Todd R, Chou MY, Matossian K, Gallagher GT, Donoff RB, Wong DTW. Cellular sources of transforming growth factor-alpha in human oral cancer. Journal of Dental Research. 1991;70:917–923
  30. Birchall MA, Schock E, Harmon BV, Gobe G. Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity (prospective, in vivo study). Oral Oncology. 1997;33:419–425

PII: S1368-8375(01)00055-0

Oral Oncology
Volume 38, Issue 3 , Pages 274-280 , April 2002

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