Oral Oncology
Volume 38, Issue 3 , Pages 244-250 , April 2002

Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland

  • K Okamura

      Affiliations

    • Department of Oral Pathology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan
    • ,
  • T Kiyoshima

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • K Shima

      Affiliations

    • Oral and Maxillofacial Oncology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • I Kobayashi

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • K Matsuo

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • H Ishibashi

      Affiliations

    • Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • S Komatsu

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • A.M.E Rasul

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • H Sakai

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author. Tel. +81-92-642-6325; fax: +81-92-642-6329

Received 28 February 2001 ,Accepted 19 March 2001.

References 

  1. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet. 1979;5:957–971
  2. Haglund C, Roberts PJ, Kuusela P, Scheinin TM, Makela O, Jalanko H. Evaluation of CA19-9 as a serum tumor marker in pancreatic cancer. Br J Cancer. 1986;53:197–202
  3. Satomura Y, Sawabu N, Takemori Y, et al.  Expression of various carbohydrate antigens in malignant and nonmalignant pancreatic tissues. Pancreas. 1991;6:448–458
  4. Lundin J, Roberts PJ, Kuusela P, Haglund C. The prognostic value of preoperative serum levels of CA19-9 and CEA in patients with pancreatic cancer. Br J Cancer. 1994;69:515–519
  5. Herlyn M, Sears HF, Steplewski Z, Koprowski H. Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma. J Clin Immunol. 1982;2:135–140
  6. Bast RC, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest. 1981;68:1331–1337
  7. Kabawat SE, Bast RC, Welch WR, Knapp RC, Colvin RB. Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types. Am J Clin Pathol. 1983;79:98–104
  8. Bast RC, Klug TL, St John E, et al.  A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983;309:883–887
  9. Canney PA, Moore M, Wilkinson PM, James RD. Ovarian cancer antigen CA125 (a prospective clinical assessment of its role as a tumor marker). Br J Cancer. 1984;50:765–769
  10. Klug TL, Bast RC, Niloff JM, Knapp RC, Zurawski VR. Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA125) associated with human epithelial ovarian carcinomas. Cancer Res. 1984;44:1048–1053
  11. Hanisch FG, Uhlenbruck G, Dienst C, Stottrop M, Hippauf E. CA125 and CA19-9 (two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk). Eur J Biochem. 1985;149:323–330
  12. de Bruijn HW, Calkoen-Carpay TVB, Jager S, Duk JM, Aalders JG, Fleuren GJ. The tumor marker CA125 is a common constituent of normal cervical mucus. Am J Obstet Gynecol. 1986;154:1088–1091
  13. Nouwen EJ, Pollet DE, Eerdekens MW, Hendrix PG, Briers TW, De Broe ME. Immunohistochemical localization of placental alkaline phosphatase, carcinoembryonic antigen, and cancer antigen 125 in normal and neoplastic human lung. Cancer Res. 1986;46:866–876
  14. Niloff JM, Bast RC, Schaetzl EM, Knapp RC. Predictive value of CA125 antigen levels in second-look procedures for ovarian cancer. Am J Obstet Gynecol. 1985;151:981–986
  15. Davis HM, Zurawski VRJ, Bast RCJ, Klug TL. Characterization of the CA125 antigen associated with human epithelial ovarian carcinomas. Cancer Res. 1986;46:6143–6148
  16. Seifert G, Sobin LH. Definitions and explanatory notes. In: Histological typing of salivary gland tumors. WHO International Histological Classification of Tumours. 2nd ed. Berlin: Springer-Verlag, 1991; pp. 11–38.
  17. Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer. 1992;69:2021–2030
  18. Ellis GL, Auclair PL. Malignant epithelial tumors. In:  Rosai J,  Sobin LH editor. Tumors of the Salivary Glands. 3rd Series. Washington, DC: Armed Forces Institute of Pathology; 1996;p. 155–373
  19. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands (clinical and histopathologic analysis of 234 cases with evaluation of grading criteria). Cancer. 1998;82:1217–1224
  20. Sobin LH, Wittekind CH. Head and Neck Tumors. In: International Union Against Cancer (Union Internationale Contre le Cancer, UICC): TNM classification of malignant tumors, 5th ed. New York: Wiley–Liss, 1997: pp. 43–46.
  21. Kamisawa T, Fukayama M, Koike M, et al.  Carcinoma of the ampulla of Vater (expression of cancer-associated antigens inversely correlated with prognosis). Am J Gastroenterol. 1988;83:1118–1123
  22. Skates SJ, Xu FJ, Yu YH, et al.  Toward an optimal algorithm for ovarian cancer screening with longitudinal tumor markers. Cancer. 1995;76:2004–2010
  23. Okamura K, Kobayashi I, Matsuo K, et al.  Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analysed by computer image analyser (correlation with histological grade and metastatic behaviour). Histopathology. 1997;31:540–548
  24. Huang M, Ma D, Sun K, Yu G, Guo C, Gao F. Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands. Int J Oral Maxillofac Surg. 1997;26:435–439
  25. Plambeck K, Friedrich RE, Schelzle R. Mucoepidermoid carcinoma of salivary gland origin (classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients). J Cranio-Maxillofac Surg. 1996;24:133–139
  26. Kobayashi I, Kiyoshima T, Ozeki S, et al.  Immunohistochemical and ultrastructural study of papillary cystadenocarcinoma arising from the sublingual gland. J Oral Pathol Med. 1999;28:282–286
  27. Kannagi R, Kitahara A, Itai S, et al.  Quantitative and qualitative characterization of human cancer-associated serum glycoprotein antigens expressing epitopes consisting of sialyl or sialyl-fucosyl type I chain. Cancer Res. 1988;48:3856–3863
  28. Phillips ML, Nudelman E, Gaeta FC, et al ELAM. 1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science. 1990;250:1130–1132
  29. Majuri ML, Mattila P, Renkonen R. Recombinant E-selectin-protein mediates tumor cell adhesion via sialyl-Le(a) and sialyl-Le(x). Biochem Bioph Res Co. 1992;182:1376–1382
  30. Shimono R, Mori M, Akazawa K, Adachi Y, Sugimachi K. Immunohistochemical expression of carbohydrate antigen 19-9 in colorectal carcinoma. Am J Gastroenterol. 1991;86:101–105
  31. Ikeda Y, Mori M, Kido A, Simono R, Matsushima T, Sugimachi K. Saku M Immunohistochemical expression of carbohydrate antigen 19-9 in gastric carcinoma. Am J Gastroenterol. 1991;86:1163–1166
  32. Ohta T, Nagakawa T, Fonseca L, Yishimitu Y, Miyazaki I, Terada T. Stromal distribution of CA 19-9 as a predictor of lymph node metastasis. Oncology. 1994;51:238–243
  33. Narimatsu H, Iwasaki H, Nakayama F, et al.  Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res. 1998;58:512–518
  34. Brooks SE, Timmerman J, Lau CC, Tsao SW, Knapp RC, Sheets EE. Effect of differentiation agents on expression of CA125, alkaline phosphatase, and cytokeratins in human ovarian adenocarcinoma cells (OVCA 433). Gynecol Oncol. 1991;42:265–272
  35. Marth D, Lang T, Koza A, Mayer I, Daxenbichler G. Transforming growth factor-beta and ovarian carcinoma cells (regulation of proliferation and surface antigen expression). Cancer Lett. 1990;51:221–225
  36. Grunt TW, Oeller H, Somay C, Dittrich C. Different propensity for spontaneous differentiation of cell clones isolated from the human ovarian surface epithelial cell line HOC-7. Differentiation. 1993;53:45–50
  37. Kurbacher CM, Jager W, Kurbacher JA, Bittl A, Wildt L, Lang N. Influence of human luteinizing hormone on cell growth and CA125 secretion of primary epithelial ovarian carcinomas in vitro. Tumour Biol. 1995;16:374–384
  38. Skalova A, Leivo I, Von-Boguslawsky K, Saksela E. Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin. Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections. J Pathol. 1994;173:13–21
  39. Zhao M, Zhao QX, Saitoh M, et al.  Proliferating patterns of salivary gland adenocarcinomas with the use of PCNA labeling. Anticancer Res. 1996;16:2693–2698
  40. Fonseca I, Félix A, Soares J. Cell proliferation in salivary gland adenocarcinomas with myoepithelial participation (a study of 78 cases). Virchows Arch. 1997;430:227–232
  41. Jansson A, Sun XF. Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas. APMIS. 1997;105:730–734
  42. Dellas A, Schultheiss E, Almendral AC, et al.  Altered expression of mdm-2 and its association with p53 protein status, tumor-cell-proliferation rate and prognosis in cervical neoplasia. Int J Cancer. 1997;74:421–425
  43. Veneroni S, Silvestrini R, Costa A, Salvatori P, Faranda A, Molinari R. Biological indicators of survival in patients treated by surgery for squamous cell carcinoma of the oral cavity and oropharynx. Oral Oncol. 1997;33:408–413
  44. Struikmans H, Rutgers DH, Hordijk GJ, Slootweg PJ, van der Tweel I, Battermann JJ. Prognostic significance of cell proliferation markers and DNA-ploidy in head and neck tumors. Int J Radiat Oncol Biol Phys. 1998;40:27–34

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Oral Oncology
Volume 38, Issue 3 , Pages 244-250 , April 2002

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