Oral Oncology
Volume 38, Issue 3 , Pages 244-250, April 2002

Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland

  • K Okamura

      Affiliations

    • Department of Oral Pathology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan
    • ,
  • T Kiyoshima

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • K Shima

      Affiliations

    • Oral and Maxillofacial Oncology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • I Kobayashi

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • K Matsuo

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • H Ishibashi

      Affiliations

    • Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • S Komatsu

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • A.M.E Rasul

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • ,
  • H Sakai

      Affiliations

    • Laboratory of Oral Pathology and Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author. Tel. +81-92-642-6325; fax: +81-92-642-6329

Received 28 February 2001; accepted 19 March 2001.

Abstract 

This study examined the immunohistochemical expression of carbohydrate antigens CA19-9 and CA125 and their relationship to various biological parameters in 27 mucoepidermoid carcinomas (MEC) and 18 adenoid cystic carcinomas (ACC) arising from salivary glands. The series showed higher immunopositivity for CA125 (67% for MEC; 33% for ACC) than for CA19-9 (59% for MEC; 11% for ACC). CA19-9 epitope was mainly expressed in cystic (MEC) and cribriform/tubular (ACC) components of carcinoma tissues. Solid components in MEC occasionally showed positive staining for CA19-9. CA125 was evenly expressed in both ACC and MEC tissues regardless of their different histological components. The positive expression of CA19-9 and CA125 in the carcinoma tissues did not influence the clinical course of patients with MEC and ACC. A significant relationship was only demonstrated between the immunohistochemical expression of CA125 and the low proliferative activity (LI) evaluated by Ki-67 immunohistochemistry. However, no significant relationship was found between LI and the patients' clinical course. These results suggest that the immunostaining for CA19-9 and CA125 provide no reliable data to predict the clinical course of patients with MEC and ACC of the salivary glands.

Keywords:  CA19-9, CA125, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary gland

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PII: S1368-8375(01)00049-5

Oral Oncology
Volume 38, Issue 3 , Pages 244-250, April 2002

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