Oral Oncology
Volume 38, Issue 1 , Pages 35-40 , January 2002

Warthin's tumour: a study of 78 cases with emphasis on bilaterality, multifocality and association with other malignancies

  • E Maiorano

      Affiliations

    • Department of Pathological Anatomy and Genetics, Section of Pathological Anatomy, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    • Corresponding Author InformationCorrespopnding author. Tel.: +39-080-5478-292; fax: +39-080-5478-280
  • ,
  • L Lo Muzio

      Affiliations

    • Department of Dental Sciences, University of Ancona, Ancona, Italy
  • ,
  • G Favia

      Affiliations

    • Department of Dental Sciences, Centre for the Study of Oral Tumours, University of Bari, Bari, Italy
  • ,
  • A Piattelli

      Affiliations

    • Department of Dental Sciences, University of Chieti, Chieti, Italy

Received 27 September 2000 ,Revised 25 October 2000 ,Accepted 17 January 2001.

References 

  1. Shugar JM, Som PM, Biller HF. Warthin's tumour, a multifocal disease. Ann Otol Rhinol Laryngol. 1982;91:246–249
  2. Tveteras K, Kristensen S. Warthin's tumour with bilateral synchronous presentation. Survey of the literature and a new case. J Laryngol Otol. 1986;100:487–492
  3. Lamelas J, Terry JHJ, Alfonso AE. Warthin's tumour (multicentricity and increasing incidence in women). Am J Surg. 1987;154:347–351
  4. Nishikawa H, Kirkham N, Hogbin BM. Synchronous extra-parotid Warthin's tumour. J Laryngol Otol. 1989;103:792–793
  5. Beck LD, Maguda TA. Papillary cystadenoma lymphomatosum (Warthin's tumor) (a multicentric benign tumor). Laryngoscope. 1967;77:1840–1848
  6. Warthin A. Papillary cystadenoma lymphomatosum. J. Cancer Res. 1929;13:116–125
  7. Lam KH, Ho HC, Ho CM, Wei WI. Multifocal nature of adenolymphoma of the parotid. Br J Surg. 1994;81:1612–1614
  8. Aguirre JM, Echebarria MA, Martinez-Conde R, Rodriguez C, Burgos JJ, Rivera JM. Warthin tumor. A new hypothesis concerning its development. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:60–63
  9. Chaudhry AP, Gorlin RJ. Papillary cystadenoma lymphomatosum (adenolymphoma). Am J Surg. 1958;95:923–931
  10. Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch [Pathol Anat]. 1980;388:13–38
  11. Eveson JW, Cawson RA. Warthin's tumor (cystadenolymphoma) of salivary glands. A clinicopathologic investigation of 278 cases. Oral Surg Oral Med Oral Pathol. 1986;61:256–262
  12. Foote FW, Franzell EL. Tumors of the major salivary glands. Cancer. 1953;6:1065–1133
  13. Yoo GH, Eisele DW, Askin FB, Driben JS, Johns ME. Warthin's tumor (a 40-year experience at The Johns Hopkins Hospital). Laryngoscope. 1994;104:799–803
  14. Talmi YP, Horowitz Z, Odenheimer NS, Wolf M, Horowitz A, Kronenberg J. Familial occurrence of Warthin's tumour. J Otolaryngol. 1994;23:206–207
  15. Seifert G, Donath K. Multiple tumours of the salivary glands — terminology and nomenclature. Eur J Cancer B Oral Oncol. 1996;32B:3–7
  16. Patz S, Mobius H. Simultaneous occurrence of a cystadenolymphoma (Warthin tumor) in the parotid gland and larynx. Hno. 1997;45:91–93
  17. Zappia J, Sullivan M, McClatchey C. Unilateral multicentric Warthin's tumors. J Otolaryngol. 1991;20:93–96
  18. Lefor AT, Ord RA. Multiple synchronous bilateral Warthin's tumors of the parotid glands with pleomorphic adenoma. Case report and review of the literature. Oral Surg Oral Med Oral Pathol. 1993;76:319–324
  19. Leverstein H, Van der Wal JE, Tiwari RM, Van der Waal I, Snow GB. Results of the surgical management and histopathological evaluation of 88 parotid gland Warthin's tumours. Clin Otolaryngol. 1997;22:500–503
  20. Brandwein M, Huvos A. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15:514–528
  21. Vanhaudenarde JM, Chevalier D, Delmotte J, Piquet JJ. Les cystadenolymphomes de la parotide (etude de 40 cas). Acta Otorhinolaryngol Belg. 1988;42:413–421
  22. Gnepp DR, Schroeder W, Heffner D. Synchronous tumors arising in a single major salivary gland. Cancer. 1989;63:1219–1224
  23. Ibi A, Yokobayashi T, Kawasaki T, Nakajima T. Bilateral Warthin's tumor (report of case and review of Japanese literature). J Oral Surg. 1981;39:362–366
  24. Toida M, Mukai K, Shimosato Y, Ebihara S. Simultaneous occurrence of bilateral Warthin's tumors and pleomorphic adenoma in the parotid glands. J Oral Maxillofac Surg. 1990;48:1109–1113
  25. Gaillard A, Nicouleau P, Jacquemaire D, Le Neel N, Cousin C. Cystadenolymphomes multiples des paroties et de la sevre superieure. Rev Stomatol Chir Maxillofac. 1981;82:282–285
  26. Finkelstein DM, Noyek AM, Chapnik JS. Multiple bilateral synchronous Warthin's tumors (a case report and review of the literature). J Otolaryngol. 1989;18:357–361
  27. Dietert SE. Papillary cystadenoma lymphomatosum (Warthin's tumor) in patients in a general hospital over a 24-year period. Am J Clin Pathol. 1975;63:866–875
  28. Nishikawa H, Kirkham N, Hogbin B. Synchtonous extra-parotid Warthin's tumour. J Laryngol Otol. 1989;103:792–793
  29. Li C, Okamoto Y, Ohmura H, Ogawa K, Shrestha P, Mori M. Expression of cytokeratins in Warthin's tumour (adenolymphoma) of parotid glands (specific detection of individual cytokeratin types by monoclonal antibodies). Eur J Cancer B Oral Oncol. 1996;32B:352–358
  30. Uchinuma E, Shioya N. Unilateral multiple adenolymphomas originating in the parotid gland (a clinicopathological study). Scand J Plast Reconstr Surg Hand Surg. 1997;31:239–243
  31. Vigliani R. Adenolymphoma and microadenolymphoma. Histomorphogenetic considerations. Pathologica. 1990;82:637–652
  32. Nordkvist A, Mark J, Dahlenfors R, Bende M, Stenman G. Cytogenetic observations in 13 cystadenolymphomas (Warthin's tumors). Cancer Genet Cytogenet. 1994;76:129–135
  33. Chung YF, Khoo ML, Heng MK, Hong GS, Soo KC. Epidemiology of Warthin's tumour of the parotid gland in an Asian population. Br J Surg. 1999;86:661–664
  34. Gallo O, Bocciolini C. Warthin's tumour associated with autoimmune diseases and tobacco use. Acta Otolaryngol. 1997;117:623–627
  35. Santucci M, Gallo O, Calzolari A, Bondi R. Detection of Epstein-Barr viral genome in tumor cells of Warthin's tumor of parotid gland. Am J Clin Pathol. 1993;100:662–665
  36. Maiorano E, Favia G, Viale G. Lymphoepithelial cysts of salivary glands (an immunohistochemical study of HIV-related and HIV-unrelated lesions). Hum Pathol. 1998;29:260–265
  37. Assor D. Bilateral carcinoma of the parotid, one cancer arising in a Warthin's tumour. Am J Clin Pathol. 1974;61:270–274
  38. Seifert G. Bilateral mucoepidermoid carcinomas arising in bilateral pre-existing Warthin's tumours of the parotid gland. Oral Oncol. 1997;33:284–287
  39. Yoshimura Y, Tawara K, Yoshigi J, Nagaoka S. Concomitant salivary duct carcinoma of a minor buccal salivary gland and papillary cystadenoma lymphomatosum of a cervical lymph node (report of a case and review of the literature). J Oral Maxillofac Surg. 1995;53:448–453
  40. Goh P, Cheah E. Synchronous tumours of the parotid gland with different histology. Br J Oral Maxillofac Surg. 1989;23:198–202
  41. Schilling J, Block B, Speigel J. Synchronous unilateral parotid neoplasms of different histologic types. Head Neck. 1989;11:179–183
  42. Nagao T, Sugano I, Ishida Y, Tajima Y, Furuya N, Kondo Y, et al. Mucoepidermoid carcinoma arising in Warthin's tumour of the parotid gland: report of two cases with histopathological, ultrastructural and immunohistochemical studies. Histopathology. 1998;33:379–386
  43. Slavin JL, Woodford NW, Busmanis I. Synchronous parotid myoepithelioma and Warthin's tumour. Pathology. 1995;27:199–200
  44. Medeiros L, Rizzi R, Lardelli P, Jaffe E. Malignant lymphoma involving a Warthin's tumour (a case with immunophenotypic and gene rearrangement analysis). Hum Pathol. 1990;21:974–977
  45. Bunker M, Locker J. Warthin's tumour with malignant lymphoma. DNA analysis of paraffin-embedded tissue. Am J Clin Pathol. 1989;91:341–344
  46. Badve S, Evans G, Mady S, Coppen M, Sloane J. A case of Warthin's tumour with coexistent Hodgkin's disease. Histopathology. 1993;22:280–281
  47. Franzen A, Koegel K. Synchronous double tumours of the parotid gland. Laryngorhinootologie. 1996;75:437–440

PII: S1368-8375(01)00019-7

Oral Oncology
Volume 38, Issue 1 , Pages 35-40 , January 2002