Oral Oncology
Volume 38, Issue 1 , Pages 30-34, January 2002

Establishment and characterization of a human adenoid cystic carcinoma line of the salivary gland which is serially transplantable and spontaneously metastasises to the lung in nude mice

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan

Received 11 December 2000; accepted 4 January 2001.

Abstract 

Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the head and neck occurring in the salivary glands. We established a human ACC line which is serially transplantable in nude mice and designated it as KOA-1. The KOA-1 tumour doubled in 9.3 days and retained the histological characteristics of a solid pattern of ACC even after 22 serial passages. The KOA-1 metastasised to the lung when transplanted subcutaneously into the back. This tumour line may serve as a useful model for exploration of the biological behaviour and treatment of human ACC.

Keywords:  Adenoid cystic carcinoma, Transplantation, Nude mice, Lung metastasis

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PII: S1368-8375(01)00010-0

Oral Oncology
Volume 38, Issue 1 , Pages 30-34, January 2002

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