Oral Oncology
Volume 38, Issue 1 , Pages 6-15 , January 2002

Mapping of the candidate tumor suppressor genes’ loci on human chromosome 3 in head and neck squamous cell carcinoma of an Indian patient population

  • S Dasgupta

      Affiliations

    • Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India
  • ,
  • N Mukherjee

      Affiliations

    • Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India
  • ,
  • S Roy

      Affiliations

    • Department of Human Genetics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta 700032, India
  • ,
  • A Roy

      Affiliations

    • Department of Pathology, Medical College and Hospital, Calcutta 700073, India
  • ,
  • A Sengupta

      Affiliations

    • Cancer Center and Welfare Home, Calcutta 700063, India
  • ,
  • S Roychowdhury

      Affiliations

    • Department of Human Genetics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta 700032, India
  • ,
  • C.K Panda

      Affiliations

    • Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India
    • Corresponding Author InformationCorresponding author. Tel.: +91-33-476-5101, ext. 328; fax: +91-33-475-7606

Received 26 August 2000 ,Accepted 13 November 2000.

References 

  1. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. International Journal of Cancer. 1993;54:594–600
  2. Saranath D, Bhoite LT, Deo MG. Molecular lesions in human oral cancer: the Indian scene. Oral Oncology, European Journal of Cancer. 1993;29B:107–112
  3. Wu CL, Sloan P, Read AP, Harris R, Thakker N. Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma of the oral cavity. Cancer Research. 1994;54:6484–6488
  4. Sauders WS, Shuster S, Huang X, Gharaibeh , Enynihi AK, Petersen I, et al.  Chromosomal instability and cytoskeletal defects in oral cancer cells. Proceedings of the National Academy of Sciences USA. 2000;97:303–308
  5. Hittleman WN, Voravud N, Shin DM, Lee JS, Ro JY, Hong WK. Early genetic changes during upper aerodigestive tract tumorigenesis. Journal of Cellular Biochemistry. 1993;17F:233–236
  6. Van Dyke D, Worsham MJ, Benninger MS, Krause CJ, Baker SR, Wolf GT, et al.  Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region. Genes Chromosomes and Cancer. 1994;9:192–206
  7. Sreekantaiah C, Rao PH, Xu L, Sacks PG, Schantz SP, Chaganti RSK. Consistent chromosomal losses in head and neck squamous cell carcinoma cell line. Genes Chromosomes and Cancer. 1994;11:29–39
  8. Jin YS, Heim S, Mandahl N, Biorkund A, Wennerberg J, Mittleman F. Nonrandom chromosome abnormalities in short-term cultured primary squamous cell cacinomas of the head and neck. Genes Chromosomes and Cancer. 1990;1:209–215
  9. Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T. Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Oncogene. 1995;11:1997–2004
  10. Kok K, Naylor SL, Buys CHCM. Deletion of the short arm of chromosome 3 in solid tumors and the search for tumor suppressor genes. Advances in Cancer Research. 1997;71:27–92
  11. Maestro R, Gasparoyyo D, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M. Three distinct regions of deletion at 3p in head and neck cancer. Cancer Research. 1993;53:5775–5779
  12. Field JK, Tsiriotis C, Zoumpourlis V, Howard P, Spandidos DA, Jones AS. Allele loss on chromosome 3 in squamous cell carcinoma of the head and neck correlates with poor clinical prognostic indicators. International Journal of Oncology. 1994;4:543–549
  13. Ah-see KW, Cooke TE, Pickford IR, Souter P, Balmain A. An allelotype of squamous cell carcinoma of the head and neck using microsatellite markers. Cancer Research. 1994;54:1617–1621
  14. Latif F, Fivash M, Glenn G, Tory K, Orcut ML, Hampsch K, et al.  Chromosome 3p deletion in head and neck carcinoma: statistical ascertainment of allelic loss. Cancer Research. 1992;52:1451–1456
  15. Li X, Lee NK, Ye Y-W, Waber PG, Schweitzer C, Cheng Q-C, et al.  Allelic loss at chromosomes 3p, 8p, 13q and 17p associated with poor prognosis in head and neck cancer. Journal of National Cancer Institute. 1994;86:1524–1529
  16. Nawroz H, Riet PVD, Hruban RH, Koch W, Ruppert JM, Sidransky D. Allelotype of head and neck squamous cell carcinoma. Cancer Research. 1997;54:1152–1155
  17. Partridge M, Kiguwa S, Langdon JD. Frequent deletion of chromosome 3p in oral squamous cell carcinoma. International Journal of Oncology. 1994;30B:248–251
  18. Partridge M, Emilion G, Langdon JD. LOH at 3p correlates with a poor survival in oral squamous cell carcinoma. British Journal of Cancer. 1996;73:366–371
  19. Jones MH, Nakamura Y. Deletion mapping of chromosome 3p in female genital tract malignancies using microsatellite polymorphism. Oncogene. 1992;7:1631–1634
  20. Chen L-C, Matsumura K, Deng G, Kurisu W, Ljung BM, Lerman MI, et al.  Deletion of two separate regions on chromosome 3p in breast cancer. Cancer Research. 1994;54:3021–3024
  21. Kok K, Oshinga J, Carritt B, Davis MB, Van der Hout AH, Van der Veen AY, Landsvater RM, De Leij LFMH, Berendsen HH, Postmus PE, Poppema S, Buys CHCM. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 1987;578–81.
  22. Todd S, Franklin WA, Varella-Garcia M, Kennedy T, Hilliker CE, Hahner L, et al.  Homozygous deletion of human chromosome 3p12 in lung tumors. Cancer Research. 1997;57:1344–1352
  23. Hampton GM, Larson AA, Baergen RN, Sommers RL, Kern S, Cavenee WK. Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semiautomated fluorescence-based deletion: subregional mapping of chromosome 4 in cervical carcinoma. Proceedings of National Academy of Sciences USA. 1996;93:6704–6709
  24. Arzimanoglou II, Gilbert F, Barber HRK. Microsatellite instability in human solid tumors. Cancer. 1998;82:1808–1820
  25. Oh Y, Mao L. Biomarkers in head and neck carcinoma. Current Opinion of Oncology. 1997;9:247–256
  26. Wistuba II, Behrens C, Milchgrub S, Bryant D, Hung J, Minna JD, et al.  Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene. 1999;18:643–650
  27. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. 2nd ed.. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory; 1989;
  28. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, et al.  A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature. 1996;380:iii–A138
  29. Melamed J, Einhorn JM, Ittamann MM. Allelic loss on chromosome 13q in human prostate carcinoma. Clinical Cancer Research. 1997;3:1867–1872
  30. Dillon EK, Boer WB, De Papadimitriou JM, Turbett GR. Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors. British Journal of Cancer. 1997;76:156–162
  31. Ishwad CS, Ferrel RE, Rossie KM, Appel BN, Johnson JT, Myers EN, et al.  Microsatellite instability in oral cancer. International Journal of Cancer. 1995;64:332–335
  32. Mao L, Lee DJ, Tockman MS, Erozan YS, Askin F, Sidransky D. Microsatellite alterations as clonal markers for the detection of human cancer. Proceedings of National Academy of Sciences USA. 1994;91:9871–9875
  33. Kwok-Wai Lo, Tsao S-W, Sing-Faileung , Choi PHK, Lee JCK, Huang DP. Detailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomas. International Journal of Oncology. 1994;4:1359–1364
  34. Schneider BG, Pulitzer DR, Brown RD, Prihoda TJ, Bostwick DGV, Saldiver Rodriguez-Martinez HA, et al.  Allelic imbalances in gastric cancer: an affected site on chromosome arm 3p. Genes Chromosmes and Cancer. 1995;13:263–271
  35. Lubinski J, Hadaczek P, Podolsky J, Toloczko A, Sikorski A, Mccue P, et al.  Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinoma. Cancer Research. 1994;54:3710–13
  36. Scholes AGM, Woolger JA, Boyle MA, Brown JS, Vaugan ED, Hart CA, et al.  Synchronous oral carcinomas: independent or common clonal origin?. Cancer Research. 1998;58:2003–2006
  37. Adamson R, Jones AS, Field JK. Loss of heterozygosity studies on chromosome 17 in head and neck cancer using microsatellite markers. Oncogene. 1994;9:2077–2083
  38. Varella-Garcia M, Gemmill RM, Rabenhorst SH, Lotto A, Drabkin HA, Archer PA, et al.  Chromosomal duplication accompanies allelic loss in non-small cell lung carcinoma. Cancer Research. 1998;58:4701–4707
  39. Varley JM, Mcgown G, Throncroft M, James LA, Margison GP, Forster G, et al.  Are there low penetrance TP53 alleles? Evidence from childhood adrenocortical tumors. American Journal of Human Genetics. 1999;65:995–1006
  40. Imreh S, Wang Y, Panda CK, Babonits M, Axelson H, Silva S, et al.  Hypersomy of chromosome 15 with retrovirally rearranged c-myc, loss of germline c-myc and IgK/c-myc juxtaposition in a macrophage-monocytic tumor line. European Journal of Cancer. 1994;30A:994–1002
  41. Imreh S, Kost-Alimova M, Kholodnyuk I, Yang Y, Szeles A, Kiss H, et al.  Differential elimination of 3p and retention of 3q segments in human/mouse microcell hybrids during tumor growth. Genes Chromosomes and Cancer. 1997;20:224–233
  42. Daigo Y, Nishiwaki T, Kawasoe T, Tamari M, Tsuchiya E, Nakamura Y. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Research. 1999;59:1966–1972
  43. Sundaresan V, Chung G, Heppel-Parton A, Xiong J, Grundy C, Roberts I, et al.  Homozygous deletion at 3p12 in breast and lung cancer. Oncogene. 1998;17:1723–1729
  44. Lovell M, Lott ST, Wong P, El-Naggar A, Tucker S, Killary AM. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Research. 1999;59:2182–2189

PII: S1368-8375(00)00131-7

Oral Oncology
Volume 38, Issue 1 , Pages 6-15 , January 2002